The Grooved Nucleus A Useful Diagnostic Criterion of Papillary Carcinoma of the Thyroid

Chan, John K.; Saw, Daisy

doi:10.1097/00000478-198610000-00002

Cited by 114 publications

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“…This histo-pathologic distribution of thyroid cancer is comparable to international literature, as well as with what has been reported previously from Saudi Arabia [1,3,12,14,[16][17][18].…”

Section: Discussionsupporting

confidence: 90%

“…These symptoms are not specific for malignant diseases and may present in benign conditions or absent in malignnant conditions [15][16][17]. Benign lesions accounted for only 25%.…”

Section: Discussionmentioning

confidence: 99%

“…Papillary carcinoma has been reported as the commonest malignant thyroid tumor with a variable frequency of 57% to 93% [16,[19][20][21][22][23][24][25]. It is interesting to note that papillary carcinoma of thyroid gland varied in many studies accounting for 60% in Pakistan, 63.6% in France, 87% in Spain and 100% in India.…”

Section: Discussionmentioning

confidence: 99%

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Pattern of Thyroid Cancer in the Eastern Province of Saudi Arabia: University Hospital Experience

Alamri¹

2012

JCT

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Objectives: To review the pattern of thyroid tumor, demographic data of the patients, sensitivity, and specificity of fine needle aspiration cytology; Materials and Methods: This is a retrospective analysis of patients who underwent total or near-total thyroidectomy at King Fahad Hospital of the University between 1982 and 2008. Data were analyzed for demographic characteristics, type of thyroid tumors, Fine Needle Aspirations Cytology (FNAC) yields and surgical complications; Results: A total of 143 patients with thyroid tumors underwent throidectomy. Their median age was 37.5 years. Females were predominantly affected (81%) with female to male ratio of (4:29). Thyroid carcinoma accounted for (75%) while benign tumors for (25%). The most common thyroid epithelial cancer was papillary type (74%) and was limited to thyroid tissues in almost two third of cases. Non-epithelial cancer in the form of thyroid lymphoma accounted for (4.89%) of the cases. FNAC sensitivity was 56% and specificity 92%. Surgical complications occurred in 18% of the patients; Conclusions: The commonest malignant thyroid cancer was papillary carcinoma. Thyroid cancer was more common in females. FNAC is highly accurate to confirm thyroid cancer but less sensitive in this study. Surgical complications were relatively minimal.

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Section: Discussionsupporting

confidence: 90%

“…These symptoms are not specific for malignant diseases and may present in benign conditions or absent in malignnant conditions [15][16][17]. Benign lesions accounted for only 25%.…”

Section: Discussionmentioning

confidence: 99%

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Pattern of Thyroid Cancer in the Eastern Province of Saudi Arabia: University Hospital Experience

Alamri¹

2012

JCT

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“…T he cytologic features of papillary carcinoma of the thyroid, both classic and variant types, have been well described. [1][2][3][4][5][6][7][8][9][10][11][12] The majority of tumors show classic cytologic features and, in particular, nuclear features. We believe, however, that there is an under-recognized cell type, seen in a minority of tumors, that was described by Kini (see Fig.…”

mentioning

confidence: 99%

“Histiocytoid” cells in fine-needle aspirations of papillary carcinoma of the thyroid

Renshaw

2002

Cancer

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BACKGROUND.Although the classic cytologic features of papillary carcinoma of the thyroid in fine-needle aspirates have been well described, one uncommon feature, a vacuolated, histocyte-like cell without classic nuclear changes of papillary carcinoma, has been less well characterized. METHODS.The author reviewed a large series of thyroid aspirates for specimens with these cytologic features. RESULTS.Seven specimens were identified, representing approximately 6% of all aspirates with the features of papillary carcinoma and less than 0.5% of all aspirates. The cells resembled histiocytes but were larger, more atypical, and keratin positive in the one specimen that was tested. The cells had enlarged nuclei with abundant cytoplasm that often was vacuolated. The nuclei had grainy chromatin, occasional nucleoli, and lacked grooves and prominent pseudoinclusions. The background showed numerous, hemosiderin-laden macrophages typical of cyst contents in only three specimens. Calcifications were present in six specimens and resembled psammoma bodies in two specimens. Three specimens showed papillary carcinoma at resection, two specimens had other passes from the same nodule that were diagnostic of papillary carcinoma, and two specimens were from recent patients without follow-up. Only one of the three resected tumors showed prominent cystic change. None of 50 aspirates that were diagnosed as benign cyst contents had similar atypical cells, nor did resections of six predominantly cystic,

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“…(4) In the macrofollicular (colloid) pattern, the follicles are larger than the normal gland and contain large amounts of colloid, thus making the distinction from hyperplastic nodules more difficult. 14 The differential diagnosis includes (1) dominant hyperplastic nodule, (2) minimally invasive follicular carcinoma, and (3) encapsulated follicular variant of PC. The typical uncomplicated adenoma lacks the internal lobulation of nodular hyperplasia.…”

Section: Follicular Adenomamentioning

confidence: 99%

Tumors of the Thyroid Gland: Histologic and Cytologic Features - Part 1

Muro-Cacho

2000

Cancer Control

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The Grooved Nucleus A Useful Diagnostic Criterion of Papillary Carcinoma of the Thyroid

Cited by 114 publications

References 0 publications

Pattern of Thyroid Cancer in the Eastern Province of Saudi Arabia: University Hospital Experience

Pattern of Thyroid Cancer in the Eastern Province of Saudi Arabia: University Hospital Experience

“Histiocytoid” cells in fine-needle aspirations of papillary carcinoma of the thyroid

Tumors of the Thyroid Gland: Histologic and Cytologic Features - Part 1

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