The green-synthesized curcumin-mediated zinc oxide nanoparticles (CmZnO-NP) as the exclusive antioxidant and efficient wound healing agent compared with curcumin, methanol, phenytoin, and ZnO

Dianati, Elahe; Hojati, Vida; Khayatzadeh, Jina; Balanezhad, Saeedeh Zafar

doi:10.1080/24701556.2021.1956964

Cited by 4 publications

(4 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Co‐ZnO NPs have acceptable antioxidant activity. Dianati et al 54 reported that curcumin‐mediated Cm‐ZnO NPs determined antioxidant activity with DPPH and ABTS at 500 μg/mL concentration as 18.06% and 21.033%, respectively. In our study, on the other hand, at 500 μg/mL Co‐ZnO NP concentration, DPPH and ABTS and antioxidant activity were 32.37% and 32.25%, respectively.…”

Section: Resultsmentioning

confidence: 99%

Green and eco‐friendly biosynthesis of zinc oxide nanoparticles using Calendula officinalis flower extract: Wound healing potential and antioxidant activity

Aydin Acar,

Gencer,

Pehlivanoglu

et al. 2023

International Wound Journal

View full text Add to dashboard Cite

This study aimed to produce zinc oxide nanoparticles with Calendula officinalis flower extract (Co‐ZnO NPs) using the green synthesis method. In addition, the antioxidant and wound healing potential of synthesized ZnO NPs were evaluated. The absorbance band at 355 nm, which is typical for ZnO NPs, was determined from the UV–Vis absorbance spectrum. The energy‐dispersive X‐ray spectroscopy (EDS) measurements revealed a high zinc content of 42.90%. The x‐ray diffractometer data showed Co‐ZnO NPs with an average crystallite size of 17.66 nm. The Co‐ZnO NPs did not have apparent cytotoxicity up to 10 μg/mL (IC50 25.96 μg/mL). C. officinalis ZnO NPs showed partial cell migration and percent wound closure (69.1%) compared with control (64.8%). In addition, antioxidant activities of Co‐ZnO NPs with 2,2'‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS) and 2,2 diphenyl‐1 picrylhydrazil (DPPH) were evaluated and radical scavenging activity of 33.49% and 46.63%, respectively, was determined. These results suggest that C. officinalis extract is an effective reducing agent for the green synthesis of ZnO NPs with significant antioxidant and wound healing potential.

show abstract

Section: Resultsmentioning

confidence: 99%

Green and eco‐friendly biosynthesis of zinc oxide nanoparticles using Calendula officinalis flower extract: Wound healing potential and antioxidant activity

Aydin Acar,

Gencer,

Pehlivanoglu

et al. 2023

International Wound Journal

View full text Add to dashboard Cite

show abstract

“…The in vitro antioxidant capacity of compounds is often determined using methods like DPPH, where green-synthesized ZnO NPs act as scavengers for free radicals released into the environment. DPPH, a dark purple radical, exhibits maximum absorbance at 517 nm, and its color lightens to a reduced state (light yellow) in the found that ZnO NPs synthesized via curcumin exhibited free radical scavenging activity of 18.06% at a concentration of 500 μg/mL (33).…”

Section: Antioxidant Potential Evaluationmentioning

confidence: 98%

Biosynthesis and In Vitro Antioxidant Activities of Zinc Oxide Nanoparticles with Turkish oregano (Origanum onites L.) Extract

YEŞİLOT,

AYDIN ACAR

2023

Turkish Journal of Health Science and Life

View full text Add to dashboard Cite

Plant-mediated biosynthesis of metallic nanoparticles (NPs) occurs via biomolecules containing organic functional groups found in the plant. The aim of the study was to characterize and evaluate the antioxidant properties of zinc oxide nanoparticles (ZnO NPs) synthesized from Turkish oregano (Origanum onites L.), a traditional endemic plant. Some characteristic properties of ZnO NPs were determined by using the methods that ultraviolet visible spectroscopy (UV–Vis), scanning electron microscopy (SEM), Energy Dispersive X-ray analysis (EDX) and X-ray diffraction (XRD). UV–vis absorption peak of ZnO NPs observed at about 356 nm. Spherical shaped and nano-sized Zn ONPs has been detected by SEM. EDX analysis revealed that zinc is the primary constituent (50.69 %) with strong peaks at 1 keV. The average crystallite size of ZnO NPs has been showed at 30 nm by x-ray diffractometer. Antioxidant activity was investigated using a DPPH free radical quenching assay ZnO NPs demonstrated moderate antioxidant activity by scavenging 42.07%. Ultimately, the study shows that phyto-fabricated ZnO NPs were successfully synthesized and have a reasonable antioxidant effect.

show abstract

“…In general, CmZnO-NP is considered an effective wound healing agent, apart from more in vivo studies for extinguishing the possible wound repair mechanisms that were proposed. 134 In order to understand the pathological mechanisms involved in deep tissue injury (DTI), we face long-term inflammation and loss of angiogenesis. Therefore, in a study that set out to find an appropriate wound healing agent, the CUR-loaded PLGA NPs (CPNPs) were designed and prepared.…”

Section: Nanoparticlesmentioning

confidence: 99%

“…In doing so, the H&E staining and gene expression findings revealed the upregulation of collagen and VEGF in a dose‐dependent manner, thereby, a fast rate of wound healing. In general, CmZnO‐NP is considered an effective wound healing agent, apart from more in vivo studies for extinguishing the possible wound repair mechanisms that were proposed 134 …”

Section: Nanoparticlesmentioning

confidence: 99%

Curcumin‐based nanoformulations alleviate wounds and related disorders: A comprehensive review

et al. 2023

View full text Add to dashboard Cite

Despite numerous advantages, curcumin's (CUR) low solubility and low bioavailability limit its employment as a free drug. CUR‐incorporated nanoformulation enhances the bioavailability and angiogenesis, collagen deposition, fibroblast proliferation, reepithelization, collagen synthesis, neovascularization, and granulation tissue formation in different wounds. Designing nanoformulations with controlled‐release properties ensure the presence of CUR in the defective area during treatment. Different nanoformulations encompassing nanofibers, nanoparticles (NPs), nanospray, nanoemulsion, nanosuspension, nanoliposome, nanovesicle, and nanomicelle were described in the present study comprehensively. Moreover, for some other systems which contain nano‐CUR or CUR nanoformulations, including some nanofibers, films, composites, scaffolds, gel, and hydrogels seems the CUR‐loaded NPs incorporation has better control of the sustained release, and thereby, the presence of CUR until the final stages of wound healing is more possible. Incorporating CUR‐loaded chitosan NPs into nanofiber increased the release time, while 80% of CUR was released during 240 h (10 days). Therefore, this system can guarantee the presence of CUR during the entire healing period. Furthermore, porous structures such as sponges, aerogels, some hydrogels, and scaffolds disclosed promising performance. These architectures with interconnected pores can mimic the native extracellular matrix, thereby facilitating attachment and infiltration of cells at the wound site, besides maintaining a free flow of nutrients and oxygen within the three‐dimensional structure essential for rapid and proper wound healing, as well as enhancing mechanical strength.

show abstract

The green-synthesized curcumin-mediated zinc oxide nanoparticles (CmZnO-NP) as the exclusive antioxidant and efficient wound healing agent compared with curcumin, methanol, phenytoin, and ZnO

Cited by 4 publications

References 46 publications

Green and eco‐friendly biosynthesis of zinc oxide nanoparticles using Calendula officinalis flower extract: Wound healing potential and antioxidant activity

Green and eco‐friendly biosynthesis of zinc oxide nanoparticles using Calendula officinalis flower extract: Wound healing potential and antioxidant activity

Biosynthesis and In Vitro Antioxidant Activities of Zinc Oxide Nanoparticles with Turkish oregano (Origanum onites L.) Extract

Curcumin‐based nanoformulations alleviate wounds and related disorders: A comprehensive review

Contact Info

Product

Resources

About