The great mimicker: a rare case of head and neck inflammatory pseudotumour in the presence of human immunodeficiency virus

Ramotar, Haripriya; Cheung, L.; Pitkin, Lisa

doi:10.1017/s0022215115002868

Cited by 7 publications

(9 citation statements)

References 10 publications

(23 reference statements)

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“…[16] reported a case of inflammatory pseudotumor of the head and neck mimicking a metastatic disease in a human immunodeficiency virus–positive 49-year-old female. In immunocompromised patients, the likelihood of inflammatory pseudotumor should also be considered in the differential diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Study of 18 Cases of Inflammatory Myofibroblastic Tumors with Reference to ALK-1 Expression: 5-Year Experience in a Tertiary Care Center

Telugu¹,

Prabhu

Kalappurayil

et al. 2017

J Pathol Transl Med

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BackgroundInflammatory myofibroblastic tumor is a histopathologically distinctive neoplasm of children and young adults. According to World Health Organization (WHO) classification, inflammatory myofibroblastic tumor is an intermediate-grade tumor, with potential for recurrence and rare metastasis. There are no definite histopathologic, molecular, or cytogenetic features to predict malignant transformation, recurrence, or metastasis.MethodsA 5-year retrospective study of histopathologically diagnosed inflammatory myofibroblastic tumors of various anatomic sites was conducted to correlate anaplastic lymphoma kinase-1 (ALK-1) expression with histological atypia, multicentric origin of tumor, recurrence, and metastasis. Clinical details of all the cases were noted from the clinical work station. Immunohistochemical stains for ALK-1 and other antibodies were performed. Statistical analysis was done using Fisher exact test.ResultsA total of 18 cases of inflammatory myofibroblastic tumors were found during the study period, of which 14 were classical. The female-male ratio was 1:1 and the mean age was 23.8 years. Histologically atypical (four cases) and multifocal tumors (three cases, multicentric in origin) were noted. Recurrence was noted in 30% of ALK-1 positive and 37.5% of ALK-1 negative cases, whereas metastasis to the lung, liver, and pelvic bone was noted in the ALK-1 positive group only.ConclusionsOverall, ALK-1 protein was expressed in 55.6% of inflammatory myofibroblastic tumors. There was no statistically significant correlation between ALK-1 expression, tumor type, recurrence and metastasis. However, ALK-1 immunohistochemistry is a useful diagnostic aid in the appropriate clinical and histomorphologic context.

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Section: Discussionmentioning

confidence: 99%

Clinicopathological Study of 18 Cases of Inflammatory Myofibroblastic Tumors with Reference to ALK-1 Expression: 5-Year Experience in a Tertiary Care Center

Telugu¹,

Prabhu

Kalappurayil

et al. 2017

J Pathol Transl Med

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“…Although PCG most commonly affects the lungs [6], other organs like the orbit and paranasal sinuses may also be involved frequently [7]. It has also been reported in the tonsils [8], tongue [9], lips, oral mucosa [10], periodontal tissues, and rarely in the gingiva [11–15]. The gingival PCG is exceedingly rare.…”

Section: Introductionmentioning

confidence: 99%

A Case Report of a Gingival Plasma Cell Granuloma in a Patient on Antihypertensive Therapy: Diagnostic Enigma

Gulati¹,

Ratre²,

Khetarpal³

et al. 2019

fid

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The aim of the present report was to discuss a unique case of gingival plasma cell granuloma (PCG) in a hypertensive patient on Amlodipine therapy. Also, we attempt to emphasize the importance of considering primary and advance investigations before making a definite diagnosis. PCG is an extremely rare, reactive, non-neoplastic lesion characterized by the predominance of polyclonal plasma cells. Drug-induced gingival overgrowth is a known side effect of Amlodipine. A hypertensive 60-year-old female patient reported with a chief complaint of swollen gums and discomfort in the upper front teeth region. A provisional diagnosis of Amlodipine-induced gingival overgrowth, combined gingival overgrowth, and fibroma was suggested. Surprisingly, histopathology revealed it to be a plasma cell lesion which was confirmed by advanced investigations, thereby establishing a confirmatory diagnosis of PCG.

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“…IPT associated with mycobacterial disease has been reported in skin [ 12 ], lymph nodes [ 13 ], lung [ 14 , 15 ], brain [ 16 ], and sinuses [ 17 ]. There have been cases of head and neck manifestations of IPT reported in lymph nodes, parotid, the para-pharyngeal space [ 18 ], and the tonsil [ 19 ]. IPT of the larynx are rare; in some cases there has been a history of intubation, previous surgery, or smoking [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

Laryngeal Inflammatory Pseudotumour Secondary to Mycobacterium kansasii

Al-Zahid

Wright

Reece

2018

Case Reports in Pathology

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Background Inflammatory pseudotumours (IPT) are rare benign tumours characterised by spindle-shaped histiocyte proliferation often mimicking a soft tissue sarcoma. They can occur in different parts of the body and various aetiological factors have been proposed. To our knowledge this is the first case report of IPT of the larynx caused by mycobacterial disease. Case Report We report a case of IPT of the larynx in an immunocompromised 81-year-old lady presenting with stridor and dysphagia with known disseminated Mycobacterium kansasii of the lungs. Conclusion This case demonstrates both the clinical and histological difficulties in making the diagnosis of IPT. A high index of suspicion is needed, and the importance of a multidisciplinary approach in the work-up, diagnosis, and management is highlighted.

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The great mimicker: a rare case of head and neck inflammatory pseudotumour in the presence of human immunodeficiency virus

Cited by 7 publications

References 10 publications

Clinicopathological Study of 18 Cases of Inflammatory Myofibroblastic Tumors with Reference to ALK-1 Expression: 5-Year Experience in a Tertiary Care Center

Clinicopathological Study of 18 Cases of Inflammatory Myofibroblastic Tumors with Reference to ALK-1 Expression: 5-Year Experience in a Tertiary Care Center

A Case Report of a Gingival Plasma Cell Granuloma in a Patient on Antihypertensive Therapy: Diagnostic Enigma

Laryngeal Inflammatory Pseudotumour Secondary to Mycobacterium kansasii

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