Laryngeal Inflammatory Pseudotumour Secondary to<i> Mycobacterium kansasii</i>

Al-Zahid, Saif; Wright, Tanwen; Reece, Philip

doi:10.1155/2018/9356243

Cited by 5 publications

(9 citation statements)

References 19 publications

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“…Presentations included vocal fold mucosal thickening, 11,12,15 multifocal ulcerations 14 and pseudotumor development. 13 To our knowledge, the present case is the first described laryngeal infection by a fast-growing NTM, Mycobacterium fortuitum. Mycobacterium fortuitum usually presents as a single nodule from direct inoculation of the bacterium via trauma or surgery, or as a disseminated infection in patients on steroid therapy.…”

Section: Discussionmentioning

confidence: 64%

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Atypical Laryngeal Infections: Localized Lesions from Unusual Organisms May Simulate Malignancy

Yan

Taxy

Paintal

et al. 2019

Ann Otol Rhinol Laryngol

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Objective: The identification of rare sources of laryngeal infection in immunocompetent patients. Recovered organisms were Mycobacterium tuberculosis (laryngeal tuberculosis [LTB]), Mycobacterium fortuitum (laryngeal Mycobacterium fortuitum [LMF]), and Blastomyces dermatiditis (laryngeal blastomycosis [LB]). Method: Single institution retrospective case series of three patients over a 2.5-year period and review of the literature on laryngeal infections by three atypical organisms. Results: Three patients presented with hoarseness and cough; one additionally had throat pain (LTB). Indirect laryngoscopy demonstrated diffuse laryngeal ulceration (LTB, LMF) and an exophytic, contiguous glottic mass (LB). Direct microlaryngoscopic biopsies and cultures established the diagnoses, including a frozen section in one case (LB), which prevented a simultaneously planned surgical resection. Appropriate antimicrobial therapy yielded dramatic laryngeal and corresponding vocal improvement, for which we provide unique photo and audio documentation. In the last 10 years, fewer than 500 cases of LTB have been reported in the English language medical literature, principally outside the United States. To date, there have been reports of only 34 LB and no cases of LMF. Conclusion: Atypical infections of the larynx may be localized and mimic laryngeal cancer on endoscopy. Tissue examination as well as microbiologic samples are diagnostic and complementary.

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Section: Discussionmentioning

confidence: 64%

“…NTM are classified based on pigmentation and growth rate. We found only seven documented cases of laryngeal NTM in the literature [11][12][13][14][15] including the slow-growing Mycobacterium avium, kansasii and malmoense. Presentations included vocal fold mucosal thickening, 11,12,15 multifocal ulcerations 14 and pseudotumor development.…”

Section: Discussionmentioning

confidence: 99%

Atypical Laryngeal Infections: Localized Lesions from Unusual Organisms May Simulate Malignancy

Yan

Taxy

Paintal

et al. 2019

Ann Otol Rhinol Laryngol

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“…Mycobacterium kansasii was isolated from a sputum specimen, and the hoarseness resolved with treatment for M. kansasii . The third patient was diagnosed with pulmonary M. kansasii and then developed a laryngeal inflammatory pseudotumor secondary to M. Kansasii . Our case revealed chronic isolated laryngeal involvement.…”

Section: Discussionmentioning

confidence: 68%

“…To our knowledge, only three possible patients with M. kansasii infections of the laryngopharynx have been described . This patient is the first instance of isolated vocal cord infection.…”

Section: Discussionmentioning

confidence: 98%

Chronic laryngitis caused by Mycobacterium Kansasii in a traveler

et al. 2019

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Chronic laryngitis commonly presents with dysphonia, and infectious causes include tuberculosis and endemic mycoses. We present a 58-year-old female with laryngitis for 5 years, fevers, chills, fatigue, malaise, myalgias, anterior neck pain, and night sweats after multicontinent exposure. Bronchoscopy cultures were negative. Bilateral microflap excision of vocal fold lesions demonstrated thickened epithelium and a deep vocal fold mass. Biopsy showed necrotizing granulomatous inflammation with acid-fast bacilli. Mycobacterium kansasii was identified. Treatment led to improvement in dysphonia, systemic symptoms, and vocal fold irritation. To our knowledge, this is the first case of isolated nontuberculous mycobacterial vocal fold infection.

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“…Symptoms of M. kansasii are mild under single infection, but it is known that more severe symptoms occur when contracted along with other illnesses such as inflammatory pseudotumor (3), sarcoidosis (4), and HIV (5). Especially, it has been reported that in Brazil, most patients who acquire lung disease caused by NTM had previously received tuberculosis treatment (6). These reports implied that NTM was closely associated with other diseases, and therefore is one of the important factors in pulmonary infection.…”

Section: Introductionmentioning

confidence: 99%

B Cell-Based Vaccine Transduced With ESAT6-Expressing Vaccinia Virus and Presenting α-Galactosylceramide Is a Novel Vaccine Candidate Against ESAT6-Expressing Mycobacterial Diseases

et al. 2019

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Early secretory antigenic target-6 (ESAT6) is a potent immunogenic antigen expressed in Mycobacterium tuberculosis as well as in some non-tuberculous mycobacteria (NTM), such as M. kansasii. M. kansasii is one of the most clinically relevant species of NTM that causes mycobacterial lung disease, which is clinically indistinguishable from tuberculosis. In the current study, we designed a novel cell-based vaccine using B cells that were transduced with vaccinia virus expressing ESAT6 (vacESAT6), and presenting α-galactosylceramide (αGC), a ligand of invariant NKT cells. We found that B cells loaded with αGC had increased levels of CD80 and CD86 after in vitro stimulation with NKT cells. Immunization of mice with B/αGC/vacESAT6 induced CD4+ T cells producing TNF-α and IFN-γ in response to heat-killed M. tuberculosis. Immunization of mice with B/αGC/vacESAT6 ameliorated severe lung inflammation caused by M. kansasii infection. We also confirmed that immunization with B/αGC/vacESAT6 reduced M. kansasii bacterial burden in the lungs. In addition, therapeutic administration of B/αGC/vacESAT6 increased IFN-γ+ CD4+ T cells and inhibited the progression of lung pathology caused by M. kansasii infection. Thus, B/αGC/vacESAT6 could be a potent vaccine candidate for the prevention and treatment of ESAT6-expressing mycobacterial infection caused by M. kansasii.

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Laryngeal Inflammatory Pseudotumour Secondary to Mycobacterium kansasii

Cited by 5 publications

References 19 publications

Atypical Laryngeal Infections: Localized Lesions from Unusual Organisms May Simulate Malignancy

Atypical Laryngeal Infections: Localized Lesions from Unusual Organisms May Simulate Malignancy

Chronic laryngitis caused by Mycobacterium Kansasii in a traveler

B Cell-Based Vaccine Transduced With ESAT6-Expressing Vaccinia Virus and Presenting α-Galactosylceramide Is a Novel Vaccine Candidate Against ESAT6-Expressing Mycobacterial Diseases

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