The grapefruit flavanone naringin protects against the radiation-induced genomic instability in the mice bone marrow: a micronucleus study

Jagetia, Ganesh Chandra; Reddy, Tiyyagura Koti

doi:10.1016/s1383-5718(02)00111-0

Cited by 125 publications

(84 citation statements)

References 41 publications

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“…Naringin has been found to protect against mutagenesis and lipid peroxidation [29][30][31][32]. Earlier studies from this laboratory have indicated that naringin reduced the radiation-induced micronuclei formation and chromosomal aberrations in mice and bleomycininduced DNA strand breaks in cultured V79 cells [25,33,34]. It has also been found to protect against the doxorubicin-induced caridiotoxicity without alleviating its antitumor activity in mouse [18].…”

Section: Biochemistry and Molecular Biology Journal Issn 2471-8084mentioning

confidence: 99%

The Citrus Flavanone Naringin Enhances Antioxidant Status in the Albino Rat Liver Treated with Doxorubicin

Ch¹,

Jagetia²,

Lalnuntluangi³

2016

Biochem Mol Biol J

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Section: Biochemistry and Molecular Biology Journal Issn 2471-8084mentioning

confidence: 99%

The Citrus Flavanone Naringin Enhances Antioxidant Status in the Albino Rat Liver Treated with Doxorubicin

Ch¹,

Jagetia²,

Lalnuntluangi³

2016

Biochem Mol Biol J

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“…36,37 It also protects against radiation and doxorubicin induced chromosomal damage in mouse bone marrow cells. 35,38,39 It has been found to be anti-inflammatory, antidiabetic, antifibortic, antiosteoporotic, antidyslipidemic and protected against lipodystrophy and iron induced toxicity. [40][41][42][43][44] Naringin may also have protective effects on cognition and oxidative damage.…”

Section: Introductionmentioning

confidence: 99%

Treatment of Mice with Naringin Alleviates the Doxorubicin-Induced Oxidative Stress in the Liver of Swiss Albino Mice

Ch¹,

Jagetia²,

Lalrinengi³

2017

MOJAP

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Doxorubicin a photosensitive antibiotic is frequently used to treat various malignancies in clinics; however, doxorubicin is also taken up by the normal cells of the body leading to increased oxidative stress and subsequently DNA damage and dysfunction in the cells. The agents which can reduce the adverse effect of doxorubicin will of great value. The present study has attempted to study the effect of naringin a citrus flavonoid on the doxorubicininduced oxidative stress in mice liver. The mice were administered with 0, 1, 5 or 10mg/ kg body weight of doxorubicin and treated with 10mg/kg body weight of naringin before or after doxorubicin treatment. The glutathione concentration and lipid peroxidation and activities of glutathione-s-transferase, catalase and super oxide dismutase were studied at 0.5, 1, 2 and 4h post-treatment in the mouse liver. The doxorubicin increased the lipid peroxidation in a dose dependent manner at all the post treatment times. Conversely, it attenuated the activities of glutathione-s-transferase, catalase and super oxide dismutase in dose dependent fashion and time dependent manner. A similar effect was observed for glutathione concentration. Treatment of mice with naringin before or after doxorubicin treatment elevated all the antioxidants and reduced the doxorubicin -induced lipid peroxidation. The effect of naringin pretreatment was more effective when compared to its post treatment. The naringin was very effective in reducing the oxidative stress induced by doxorubicin as indicated by the elevated levels of glutathione concentration, glutathiones-transferase, catalase and super oxide dismutase. The pretreatment of naringin was better than its post treatment.

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“…In streptozotocin (STZ)-induced diabetic rats, hyperglycaemia-elicited inflammatory response worsens cardiac tissue injury of ischaemia/reperfusion (I/R) [12]. Recently, the effects of naringin, a bioflavonoid found in grapefruit and other citrus fruits [21], on hyperglycaemia-induced cardiac injury in DM have attracted considerable attention due to its broad spectrum of pharmacological and therapeutic properties.Naringin (4 , , 5, 7-trihydroxy-flavonone-7-rhamnoglucoside)is responsible for the characteristic sour flavour of fruits [22] and has been empirically proven to have no side effects, as human beings have been ingesting grapes and citrus fruits for a long time [23]. Increasing evidence indicates that naringin has multiple pharmacological properties, including antioxidative [19,[24][25][26][27], antihypercholesterolaemic [25,27] and antiinflammatory effects [19,[26][27][28].…”

mentioning

confidence: 99%

Naringin Inhibits ROS‐activated MAPK Pathway in High Glucose‐induced Injuries in H9c2 Cardiac Cells

Chen

Guo

Yan

et al. 2013

Basic Clin Pharma Tox

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Naringin, an active flavonoid isolated from citrus fruit extracts, exhibits biological and pharmacological properties, such as antioxidant activity and antidiabetic effect. Mitogen-activated protein kinase (MAPK) signalling pathway has been shown to participate in hyperglycaemia-induced injury. The present study tested the hypothesis that naringin protects against high glucose (HG)-induced injuries by inhibiting MAPK pathway in H9c2 cardiac cells. To examine this, the cells were treated with 35 mM glucose (HG) for 24 hr to establish a HG-induced cardiomyocyte injury model. The cells were pre-treated with 80 lM naringin for 2 hr before exposure to HG. The findings of this study showed that exposure of H9c2 cells to HG for 24 hr markedly induced injuries, as evidenced by a decrease in cell viability, increases in apoptotic cells and reactive oxygen species (ROS) production, as well as dissipation of mitochondrial membrance potential (MMP). These injuries were significantly attenuated by the pre-treatment of cells with either naringin or SB203580 (a selective inhibitor of p38 MAPK) or U0126 (a selective inhibitor of extracellular signal regulated kinase 1/2, ERK1/2) or SP600125 (a selective inhibitor of c-jun N-termanal kinase, JNK) before exposure to HG, respectively. Furthermore, exposure of cells to HG increased the phosphorylation of p38 MAPK, ERK1/2 and JNK. The increased activation of MAPK pathway was ameliorated by pre-treatment with either naringin or N-acetyl-L-cysteine (NAC), a ROS scavenger, which also reduced HG-induced cytotoxicity and apoptosis, leading to increase in cell viability and decrease in apoptotic cells. In conclusion, our findings provide new evidence for the first time that naringin protects against HGinduced injuries by inhibiting the activation of MAPK (p38 MAPK, ERK1/2 and JNK) and oxidative stress in H9c2 cells.Hyperglycaemia, the most important feature of diabetes mellitus (DM), is believed to be a risk factor for the development of diabetic cardiovascular complications, such as diabetic cardiomyopathy (DCM) [1,2]. The mechanisms responsible for the deteriorative effects of hyperglycaemia on cardiomyocytes are complicated. Multiple factors, such as reactive oxygen species (ROS) production [3][4][5][6][7][8], decline of antioxidant defence systems [6-10], pro-inflammatory cytokine [11][12][13], activation of mitogen-activated protein kinase (MAPK) [14][15][16] and mitochondrial damage [17,18] have been reported to contribute to hyperglycaemia-induced injuries. Sustained hyperglycaemia has been identified as a principle mediator of ROS generation in diabetes [3,4,14,19], which leads to oxidative myocardial injury [14,20]. Furthermore, hyperglycaemia significantly increases phosphorylation of p38 MAPK and extracellular signal regulated kinase (ERK) 1/2 (members of MAPK) in left ventricle tissue of diabetic rats [14], the increased activation of MAPK is associated with the development of diabetic cardiomyopathy [14]. In streptozotocin (STZ)-induced diabetic rats, hyperglycaemia...

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The grapefruit flavanone naringin protects against the radiation-induced genomic instability in the mice bone marrow: a micronucleus study

Cited by 125 publications

References 41 publications

The Citrus Flavanone Naringin Enhances Antioxidant Status in the Albino Rat Liver Treated with Doxorubicin

The Citrus Flavanone Naringin Enhances Antioxidant Status in the Albino Rat Liver Treated with Doxorubicin

Treatment of Mice with Naringin Alleviates the Doxorubicin-Induced Oxidative Stress in the Liver of Swiss Albino Mice

Naringin Inhibits ROS‐activated MAPK Pathway in High Glucose‐induced Injuries in H9c2 Cardiac Cells

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