The Graft-Versus-Host Reactivity in Ag-B/MLR Disparate Strains of Rats

Cramer, Donald V.; Davis, Bridgett K.; Shonnard, John W.; Gill, Thomas J.

doi:10.1097/00007890-197706000-00007

Cited by 17 publications

(9 citation statements)

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“…The frequencies of the different H-1 genotypes that are to be expected if the sample of wild rats tested represents a random breeding population are not significantly different from those which have been actually observed ( Table 3). The occurrence of inbred strain MLR antigens in wild rats does not seem to be unusual, as it has been described for wild rat populations of different geographic origin [22]. This latter report [22], the data presented here as well as own unpublished results indicate that the extent of the polymorphism of the MHC in wild rats seems to be in the range of that found for man rather than being as large as in wild mice [5].…”

Section: Discussionsupporting

confidence: 73%

“…The occurrence of inbred strain MLR antigens in wild rats does not seem to be unusual, as it has been described for wild rat populations of different geographic origin [22]. This latter report [22], the data presented here as well as own unpublished results indicate that the extent of the polymorphism of the MHC in wild rats seems to be in the range of that found for man rather than being as large as in wild mice [5]. Each (T, G)-A--L responder haplotype was associated with low responsiveness to (H, G)-A--L and vice versa.…”

Section: Discussionsupporting

confidence: 54%

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Close association between particular I region‐determined cell surface antigens and Ir gene‐controlled immune responsiveness to synthetic polypeptides in wild rats

Günther¹

1979

Eur J Immunol

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The relationship between major histocompatibility complex (MHC) and genetic control of immune responsiveness to the synthetic polypeptides (T,G)-A--L [poly-(LTyr,LGlu)-poly(DLAla)--poly(LLys)] and (H,G)-A--L [poly(LHis,L-Glu)-poly-(DLAla)--poly(LLys)] has been studied in 26 wild rats. The major histocompatibility complex (MHC) genotype frequencies observed were not different from those expected according to the Hardy-Weinberg formula. More than half of the wild rats carried MHC-linked responder Ir-TGAL and Ir-HGAL genes. High or intermediate responsiveness to (T,G)-A--L and high responsiveness to (H,G)-A--L were always found to be associated with particular I region-determined cell surface antigens. These antigens could be identified serologically and by primary and secondary mixed lymphocyte reactions, and were similar or identical to I region products of (T,G)-A--L high responder or (H,G)-A--L intermediate responder inbred rat strains. The strong association between cell surface antigens and immune responsiveness could be due to linkage disequilibrium or to pleiotropy. Since the same I region-determined cell surface structure could be associated either with high or intermediate anti-(T,G)-A--L antibody titers, the presence of the Ia antigen(s) identified did not seem to guarantee high antibody responsiveness to the test antigen.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionsupporting

confidence: 54%

Close association between particular I region‐determined cell surface antigens and Ir gene‐controlled immune responsiveness to synthetic polypeptides in wild rats

Günther¹

1979

Eur J Immunol

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“…These latter antigens are shared between the RTI ~ and RT1 d (A.14), and RT1 b and RT1 a (A.18) haplotypes. From the data presented it must be concluded, that the R T1 " hyplotype is not identical to that of BN.DA (R T1 a) or AUG (R TI~)nor does it represent a combination of both as reported earlier by Cramer et al (1977b) and Radka et al (1977). Of the remaining two A antigens, A.45 is considered to be a private class I antigen of MNR, and A.43 is considered to be a public determinant shared by DA and AUG. Of the B antigens, B.1, 2, 3, and 4 are private determinants of the RTI", RTF, and RT1 ~ haplotypes, respectively.…”

Section: Discussionmentioning

confidence: 46%

The major histocompatibility complex of the rat,RT1

Götze

1978

Immunogenetics

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The antigenic determinants expressed on RBC and lymphocytes and coded for by the MHC, RT1,of the MNR (RT1 ( m )) rat strain were compared to those of the BN.DA(RT1 ( a )), ALB (RT1 ( b )), and AUG (RT1 ( c )) strains by direct cytotoxicity and absorption analysis with RT1 typing sera, sera produced against MNR cells, and sera produced in MNR responders against cells carrying thea, b, andc haplotype determinants. The results indicate that MNR shares major class I (A) antigens with DA, and major class II (B) determinants with AUG, but that MNR differs from DA and AUG with respect to both classes of determinant. It appears, therefore, that the MNR haplotype does not represent a simple composite of the two other haplotypes,RT1 ( a ) andRT1 ( c ), as reported earlier.

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“…Previous immunogenetic studies had demonstrated that the RT1 m haplotype was distinct from the RT1 o and RT1 d haplotypes with respect to the MHC class II region, including the alleles expressed at the TAP2 locus (10,34,35). We now hypothesized that the previous classification of RT1 m class Ia Ags as separate and distinct from those of the RT1 o and RT1 d haplotypes (36) was a consequence of this TAP polymorphism, and represented a new example of class I modification (cim) (see introduction).…”

Section: Class I Modification (Cim) In the Rt1 M Haplotypementioning

confidence: 99%

A Novel Instance of Class I Modification (cim) Affecting Two of Three Rat Class I RT1-A Molecules Within One MHC Haplotype

González-Muñoz

Rolle

Brun

et al. 2003

The Journal of Immunology

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T he number of genes for MHC class I molecules varies greatly between species: from ϳ11 in pigs (1) to several thousand in the African pigmy mouse (2). Among the complement of class I genes in a species, some are designated classical class I, or MHC class Ia, genes. The protein products of the class Ia genes share certain characteristics. These include high cell surface expression levels relative to the levels of MHC class Ib genes, a major role in repertoire formation and Ag presentation for substantial numbers of ␣/␤ CD8 ϩ T lymphocytes, the ability to provoke strong cellular CD8 ϩ T cell responses in the context of allotransplantation, and a tendency toward a high degree of genetic polymorphism. MHC class I genes are found at several different positions within each MHC complex. A unifying description of mammalian MHC class I gene organization has been provided by Amadou (3), who pointed out that clusters of class I genes, varying in size from one species to another, are located at certain positions within a linear framework of conventional genes that maintains an evolutionarily conserved order.The most detailed investigations of MHC class I genetics have involved studies of this system in humans and laboratory mice. Comparative studies in other species, however, have served to stress the remarkable plasticity of this system. The description of the MHC of the laboratory rat (Rattus norvegicus) is now well advanced (4). Close scrutiny of MHC class Ia gene expression in the rat has uncovered surprising differences from its fellow murine, the mouse. 1) Rat MHC class Ia genes are all located to one side (centromeric) of the MHC class II region, i.e., there is no evidence for an H2-D or -L equivalent in the rat (the rat class Ia region is called RT1-A).2) The number of MHC class Ia genes per MHC haplotype is a variable (5, 6). Similar observations have been reported for cattle (7). 3) The TAP peptide transporter, which supplies peptides for MHC class I assembly, is functionally dimorphic in the rat (8 -10). The rat MHC class Ia system has evolved alleles that apparently take advantage of the broader peptide specificity of the rat TAP-A transporter allele, while the mouse class Ia alleles reflect a more restrictive TAP, which has properties similar to those of rat TAP-B (6, 11).The polymorphism of rat TAP described above was discovered on account of a phenomenon termed class I modification (cim).4 A rat MHC class Ia allele named RT1-A a showed striking differences in expression and antigenicity for T lymphocytes depending on the genetic origin of the MHC class II region with which it was expressed (8,12,13). It emerged that allelism of the MHC class II-linked TAP2 gene was responsible for the observations. TAP heterodimers containing the TAP2A allele could readily supply the type of peptides required for RT1-A a to assemble, but those

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The Graft-Versus-Host Reactivity in Ag-B/MLR Disparate Strains of Rats

Cited by 17 publications

References 0 publications

Close association between particular I region‐determined cell surface antigens and Ir gene‐controlled immune responsiveness to synthetic polypeptides in wild rats

Close association between particular I region‐determined cell surface antigens and Ir gene‐controlled immune responsiveness to synthetic polypeptides in wild rats

The major histocompatibility complex of the rat,RT1

A Novel Instance of Class I Modification (cim) Affecting Two of Three Rat Class I RT1-A Molecules Within One MHC Haplotype

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