The Golgi ribbon and the function of the Golgins

Matteis, Maria Antonietta De; Mirоnоv, Alexander A.; Beznoussenko, Galina V.

doi:10.1007/978-3-211-76310-0_15

Cited by 19 publications

(17 citation statements)

References 100 publications

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“…The organization of the GA depends on many factors, such as the ability of cells to maintain their Golgi stacks within a restricted space and the normal functioning of the golgins and the SNARE/Rab machineries (60). Furthermore, there is the need for correct positioning and normal functioning of the centrosome, the polymerization and growing of microtubules, the presence of ER‐to‐GA transport and regulated levels of [Ca 2+ ] both in the different cytosolic regions and in the secretory compartments (60). If these machineries are blocked, the stacks will not fuse with each other and the Golgi ribbon cannot be formed (61).…”

Section: Discussionmentioning

confidence: 99%

The SPCA1 Ca2+ Pump and Intracellular Membrane Trafficking

Micaroni

Perinetti

Berrie

et al. 2010

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The Golgi apparatus (GA) is a dynamic store of Ca 2+ that can be released into the cell cytosol. It can thus participate in the regulation of the Ca 2+ concentration in the cytosol ([Ca 2+ ] cyt ), which might be critical for intra-Golgi transport. Secretory pathway Ca 2+ -ATPase pump type 1 (SPCA1) is important in Golgi homeostasis of Ca 2+ . The subcellular localization of SPCA1 appears to be GA specific, although its precise location within the GA is not known. Here, we show that SPCA1 is mostly excluded from the cores of the Golgi cisternae and is instead located mainly on the lateral rims of Golgi stacks, in tubular noncompact zones that interconnect different Golgi stacks, and within tubular parts of the trans Golgi network, suggesting a role in regulation of the local [Ca 2+ ] cyt that is crucial for membrane fusion. SPCA1 knockdown by RNA interference induces GA fragmentation. These Golgi fragments lack the cismost and trans-most cisternae and remain within the perinuclear region. This SPCA1 knockdown inhibits exit of vesicular stomatitis virus G-protein from the GA and delays retrograde redistribution of the GA glycosylation enzymes into the endoplasmic reticulum caused by brefeldin A; however, exit of these enzymes from the endoplasmic reticulum is not affected. Thus, correct SPCA1 functioning is crucial to intra-Golgi transport and maintenance of the Golgi ribbon.

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Section: Discussionmentioning

confidence: 99%

The SPCA1 Ca2+ Pump and Intracellular Membrane Trafficking

Micaroni

Perinetti

Berrie

et al. 2010

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“…The minus-end-directed motor proteins, mainly dynein-1, collect the Golgi stacks along the microtubules and form the Golgi ribbon (Brownhill et al, 2009). A common feature of the cell types that do not have a continuous Golgi ribbon (from plant cells to mammalian oocytes and myotubes) is the absence of the radial patterned microtubule around the MTOC, indicating that the microtubule organization plays important roles in Golgi ribbon formation (Matteis et al, 2008). In addition, mammalian Golgi itself has been reported to act as an MTOC to nucleate microtubules both in vitro and in vivo, and the Golgi stacks can selforganize into a single continuous unit using self-derived microtubules in cytoplasts without centrosomes (Sütterlin and Colanzi, 2010;Wei and Seemann, 2009).…”

Section: Dynamicsmentioning

confidence: 98%

“…Because the Golgi ribbon is fragmented into many pieces with typical stacked organization (the ministacks) by depolymerizing microtubules , it can be thought that the Golgi ribbon is an interconnected assemblage of the ministacks, which are very similar to the "dictyosome"-style Golgi in nonvertebrate organisms. Moreover, even in mammals, the Golgi apparatus naturally exhibits isolated stacks in certain types of cells (such as oocytes and skeletal muscle cells; Matteis et al, 2008). Hence, each discrete stacked structure as a minimum unit of the Golgi is thought to be fundamentally conserved among eukaryotes.…”

Section: Features Of Plant Golgi As Comparedmentioning

confidence: 99%

Formation and Maintenance of the Golgi Apparatus in Plant Cells

Ito

Uemura

Nakano

2014

International Review of Cell and Molecular Biology

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“…Many golgins have multiple Rab binding sites, which may facilitate capturing membranes bearing specific Rabs and excluding other cellular organelles like ribosomes from the Golgi region 65 . Based on their locations, golgins can be simply divided into cis -golgins, golgins on the rim of the stacks and trans -golgins 1, 66, 67 .…”

Section: Figmentioning

confidence: 99%

Cell cycle regulation of Golgi membrane dynamics

Tang

Wang

2013

Trends in Cell Biology

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The Golgi apparatus is a membranous organelle in the cell that plays essential roles in protein and lipid trafficking, sorting, processing and modification. Its basic structure is a stack of closely aligned flattened cisternae. In mammalian cells, dozens of Golgi stacks are often laterally linked into a ribbon-like structure. Biogenesis of the Golgi during cell division occurs through a sophisticated disassembly and reassembly process that can be divided into three distinct but cooperative steps, including the deformation and reformation of the Golgi cisternae, stacks and ribbon. Here, we review our current understanding of the protein machineries that control these three steps in the cycle of mammalian cell division: GRASP65 and GRASP55 in Golgi stack and ribbon formation; ubiquitin and AAA ATPases in post-mitotic Golgi membrane fusion; and golgins and cytoskeleton in Golgi ribbon formation.

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The Golgi ribbon and the function of the Golgins

Cited by 19 publications

References 100 publications

The SPCA1 Ca2+ Pump and Intracellular Membrane Trafficking

The SPCA1 Ca2+ Pump and Intracellular Membrane Trafficking

Formation and Maintenance of the Golgi Apparatus in Plant Cells

Cell cycle regulation of Golgi membrane dynamics

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