Biblical humanists as Lorenzo Valla, Erasmus of Rotterdam, and Jacques Lefèvre d’Étaples, amongst others, had prepared the path for the study of the Bible with the help of philological methods and the knowledge of original languages. After the advent of the Reformation, humanist biblical scholarship continued to be practised among both Catholic and Protestant theologians and philologists. This scholarship largely expressed itself in Latin (and exceptionally also in the vernacular), although it was not only based upon the Latin Bible, but even more upon the “original” Hebrew and Greek. Towards the end of the sixteenth century, the biblical–humanist approach, without disappearing altogether, was curbed by more outspoken doctrinal concerns, an evolution characteristic of an increasingly confessionalized era.