The Gm and Inv Factors in Rheumatoid
                                                  Arthritis

Archimandritis, Athanasios; Kalos, A; Παπακωνσταντίνου, Γ.; Babionitakis, A.; Theodoropoulos, George; Dimitriadis, Panayiotis

doi:10.1017/s0001566000010515

Acta genet. med. gemellol.

1975

DOI: 10.1017/s0001566000010515

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The Gm and Inv Factors in Rheumatoid Arthritis

Athanasios Archimandritis¹,

A Kalos²,

Γ. Παπακωνσταντίνου³

et al.

Abstract: The Gm(1), Gm(2), Gm(4), Gm(12), and Inv(1) factors were studied in the sera of 56 patients suffering from rheumatoid arthritis and 26 from various rheumatic diseases, by the hemagglutination inhibition test, using optimally reacting mixtures of Ragg and Nagg sera. The distribution of these factors was found to agree with that of healthy Greeks. No correlation was found between hypergammaglobulinemia and the discovery of the Gm(1) and Inv(1) factors. The presence of the rheumatoid factor was independent of the… Show more

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1977

1992

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Cited by 6 publications

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References 9 publications

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“…Polyclonal RFs from persons with RA share the cross-reactive idiotypes of monoclonal RFs (15). Reports of previous studies using the kappa allotypic marker Km (1) showed no significant association with RA in a study of British subjects (16), but in a Greek population, there was a trend toward association (17). I have found that there is an increased frequency of the homozygous C, genotype in RA (18), particularly in HLA-DR4 negative individuals (19).…”

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confidence: 65%

Variable‐Constant Segment Genotype of Immunoglobulin Kappa is Associated with Increased Risk for Rheumatoid Arthritis

Moxley

1992

Arthritis & Rheumatism

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Objective. To further investigate the association of rheumatoid arthritis (RA) with a particular genotype identified by a restriction site polymorphism near the constant segment of immunoglobulin kappa (C,).Methods. The frequencies of genomic DNA polymorphisms detected within or near C, (the most C, -proximal variable segment [V,] B3 and a T lymphocyte marker [CDSA]) were determined by Southern blotting and hybridization. The frequencies of coding-region polymorphisms of C, (Km allotypes) were determined by amplification by polymerase chain reaction followed by restriction enzyme digestion.Results. Although the frequencies of B3, Km, and CD8A genotypes were not Merent between RA and normal control populations, more individuals were homozygous for both C, and B3 in the RA group (relative risk 2.2, P < 0.01), especially in the DR4-negative RA subgroup (relative risk 3.9, P < 0.001).

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mentioning

confidence: 65%

Variable‐Constant Segment Genotype of Immunoglobulin Kappa is Associated with Increased Risk for Rheumatoid Arthritis

Moxley

1992

Arthritis & Rheumatism

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Serum Gc system in liver cirrhosis and hepatoma

Theodoropoulos¹,

Rigatos²,

Babionitakis³

et al. 1977

Hum Genet

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Serum Gm system in liver cirrhosis and hepatoma

Theodoropoulos¹,

Archimandritis²,

Drivas³

et al. 1980

Hum Genet

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Serum Gm polymorphism was studied in 69 patients with liver cirrhosis, in 64 with liver cirrhosis plus hepatoma, in 40 with hepatoma without evidence of cirrhosis, and in 256 controls. The distribution of Gm factors in liver patients differed from that in the control group, this difference apparently being due to the distribution in cirrhosis patients negative for HBsAg and anti-HBs. Furthermore, significantly more heterozygous Gm individuals were found in this group of patients than in the control group. Thus it appears that Gm heterozygous individuals are prone to develop cryptogenic cirrhosis under the influence of other, as yet undetermined factors.

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The Gm and Inv Factors in Rheumatoid Arthritis

Cited by 6 publications

References 9 publications

Variable‐Constant Segment Genotype of Immunoglobulin Kappa is Associated with Increased Risk for Rheumatoid Arthritis

Variable‐Constant Segment Genotype of Immunoglobulin Kappa is Associated with Increased Risk for Rheumatoid Arthritis

Serum Gc system in liver cirrhosis and hepatoma

Serum Gm system in liver cirrhosis and hepatoma

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