The Glycocalyx and Trauma

Chignalia, Andréia Z.; Yetimakman, Feliz; Christiaans, Sarah C.; Ünal, Şule; Bayrakçı, Benan; Wagener, Brant M.; Russell, Robert T.; Kerby, Jeffrey D.; Pittet, Jean François; Dull, Randal O.

doi:10.1097/shk.0000000000000513

Cited by 108 publications

(85 citation statements)

References 97 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Clinically, glycocalyx degradation is associated with shedding of the syndecan‐1 ectodomain. Shed ectodomains following trauma are associated with enhanced shock, inflammation, and endothelial damage and independently predict mortality in injured patients …”

Section: Plasma Recognized As a Treatment For The Endotheliopathy Of mentioning

confidence: 99%

Plasma for burn shock resuscitation: is it time to go back to the future?

2019

View full text Add to dashboard Cite

Patients with burn shock can be challenging to resuscitate. Burn shock produces a variety of physiologic derangements: Patients are hypovolemic from volume loss, have a increased systemic vascular resistance, and may have a depressed cardiac output depending on the extent of the thermal injury. Additionally, the burn wound produces a significant inflammatory cascade of events that contributes to the shock state. Fluid resuscitation is foundational for the initial treatment of burn shock. Typical resuscitation is with intravenous lactated Ringer's in accordance with well‐established formulas based on burn wound size. In the past century, as therapies to treat thermal injuries were being developed, plasma was the fluid used for burn resuscitation; in fact, plasma was used in World War II and throughout the 1950s and 1960s. Plasma was abandoned because of infectious risks and complications. Despite huge strides in transfusion medicine and the increased safety of blood products, plasma has never been readopted for burn resuscitation. Over the past 15 years, there has been a paradigm shift in trauma resuscitation: Less crystalloid and more blood products are used; this strategy has demonstrated improved outcomes. Plasma is a physiologic fluid that stabilizes the endothelium. The endotheliopathy of trauma has been described and is mitigated by transfusion strategies with a 1:1 ratio of RBCs to plasma. Thermal injury also results in endothelial dysfunction: the endotheliopathy of burns. Plasma is likely a better resuscitation fluid for patients with significant burn wounds because of its capability to restore intravascular volume status and treat the endotheliopathy of burns.

show abstract

Section: Plasma Recognized As a Treatment For The Endotheliopathy Of mentioning

confidence: 99%

Plasma for burn shock resuscitation: is it time to go back to the future?

2019

View full text Add to dashboard Cite

show abstract

“…The negatively charged glycocalyx surface forms an electrostatic barrier for plasma cells and proteins, like albumin. Increased serum levels of syndecan-1 are associated with acute coagulopathy following trauma [29].…”

Section: Function Of the Endothelial Glycocalyxmentioning

confidence: 99%

Endothelial Glycocalyx: Novel Insight into Atherosclerosis

Zeng¹

2017

J. Biomed

View full text Add to dashboard Cite

The evidence shows that endothelial glycocalyx exerts an important role in inflammation and atherosclerosis. We previously demonstrated that hydrodynamic force such as shear stress induces the remodeling of the major component of glycocalyx including glypican-1 with attached heparan sulfate, and that sphingosine-1-phosphate (S1P) protects the glycocalyx against syndecan-1 ectodomain shedding and induces the synthesis of HS. Actually, both shear stress and S1P imposed significant influence on inflammatory disease such as atherosclerosis. Therefore, it can be concluded that glycocalyx is a critical signaling platform for determining the fate of endothelial cells and atherosclerosis. This review integrated our current understanding of shear stress, S1P and glycocalyx, and also provided new insight/issues into the role of the glycocalyx in the process of forming and developing atherosclerosis.

show abstract

“…The shedding of the eGC exposes intercellular adhesion molecules (ICAMs) and P-selectin underneath the glycocalyx layer. Consequently, the eGC shedding facilitates more adhesion of inflammatory cells to the endothelium, which is followed by increased endothelial permeability and propagation of inflammation [8, 9]. On the other hand, the soluble fragments from eGC appear to have opposing actions, which are spread between inflammation and contribution to immunosuppression [10].…”

Section: Introductionmentioning

confidence: 99%

Endothelial Glycocalyx as Biomarker for Cardiovascular Diseases: Mechanistic and Clinical Implications

Kim

Nijst²,

Kiefer³

et al. 2017

Curr Heart Fail Rep

View full text Add to dashboard Cite

The endothelial surface layer is covered with abundant proteoglycans, of which syndecans and glycosaminoglycans are major constituents. Among the endothelial glycocalyx (eGC) constituents, syndecan-1 (sdc1) is a main component, and an elevated serum level of sdc1 may indicate the degradation of eGC. In patients with ischemic heart disease or heart failure, elevation of serum sdc1 has been associated with worsening cardiac and renal function; however the causal relationship between degradation of eGC and clinical outcomes is unclear. Herein, we review the previous literature on eGC in cardiovascular and non-cardiovascular diseases and their clinical implications.

show abstract

The Glycocalyx and Trauma

Cited by 108 publications

References 97 publications

Plasma for burn shock resuscitation: is it time to go back to the future?

Plasma for burn shock resuscitation: is it time to go back to the future?

Endothelial Glycocalyx: Novel Insight into Atherosclerosis

Endothelial Glycocalyx as Biomarker for Cardiovascular Diseases: Mechanistic and Clinical Implications

Contact Info

Product

Resources

About