Endothelial Glycocalyx as Biomarker for Cardiovascular Diseases: Mechanistic and Clinical Implications

Kim, Youn-Hyun; Nijst, Petra; Kiefer, Kathryn; Tang, W.H. Wilson

doi:10.1007/s11897-017-0320-5

Cited by 76 publications

(90 citation statements)

References 106 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this study, to detect the initial endothelial cell injury, we investigated syndecan-1 concentrations in patients who received comprehensive medical examinations. Several previous reports have revealed the relationships of syndecan-1 with severe diseases, such as acute kidney injury, chronic kidney disease, cardiac arrest, cardiovascular disease, and sepsis [29][30][31][32][33]. Although serum syndecan-1 concentrations were reported in several previous studies, the patient populations in these studies were small [29][30][31][32][33][34][35][36].…”

Section: Discussionmentioning

confidence: 94%

Factors Enhancing Serum Syndecan-1 Concentrations: A Large-Scale Comprehensive Medical Examination

Oda¹,

Okada²,

Suzuki³

et al. 2019

Preprint

View full text Add to dashboard Cite

Endothelial disorders are related to various diseases. An initial endothelial injury is characterized by endothelial glycocalyx injury. We aimed to evaluate endothelial glycocalyx injury by measuring serum syndecan-1 concentrations in patients during comprehensive medical examinations. A single-center, prospective, observational study was conducted at Asahi University Hospital. The participants enrolled in this study were 1313 patients who underwent comprehensive medical examinations at Asahi University Hospital from January 2018, to June 2018. One patient undergoing hemodialysis was excluded from the study. At enrollment, blood samples were obtained, and study personnel collected demographic and clinical data. No treatments or exposures were conducted except for standard medical examinations and blood sample collection. Laboratory data were obtained by collection of blood samples at the time of study enrolment. According to nonlinear regression, the concentrations of serum syndecan-1 were significantly related to age (p = 0.016), aspartic aminotransferase concentration (AST, p = 0.020), blood urea nitrogen concentration (BUN, p = 0.013), triglyceride concentration (p < 0.001), and hematocrit (p = 0.006). These relationships were independent associations. Endothelial glycocalyx injury, which is reflected by serum syndecan-1 concentrations, is related to age, hematocrit, AST concentration, BUN concentration, and triglyceride concentration.

show abstract

Section: Discussionmentioning

confidence: 94%

Factors Enhancing Serum Syndecan-1 Concentrations: A Large-Scale Comprehensive Medical Examination

Oda¹,

Okada²,

Suzuki³

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Recent findings indicate that SDC1 is elevated in serum, indicative of the degradation of GCX, in patients with ischemic heart disease or heart failure. 94 GCX shedding markers have been examined in the pathophysiology of heart failure with reduced ejection fraction (HFrEF). HA levels and SDC1 levels were measured in HFrEF patients.…”

Section: Part B: the Role Of The Glycocalyx In Vascular Related Diseamentioning

confidence: 99%

“…Martens et al . 94 tested whether PBR is increased in patients with lacunar stroke, and further distinguished patients with white matter lesions as a sign of extensive cerebral small vessel disease. They observed that white matter lesions are associated with an increase in the red blood cell permeable part of the sublingual microvascular GCX, and this implicates a compromised GCX.…”

Section: Part B: the Role Of The Glycocalyx In Vascular Related Diseamentioning

confidence: 99%

The Glycocalyx and Its Role in Vascular Physiology and Vascular Related Diseases

Weinbaum

Cancel

et al. 2020

Cardiovasc Eng Tech

View full text Add to dashboard Cite

Purpose In 2007 the two senior authors wrote a review on the structure and function of the endothelial glycocalyx layer (Weinbaum in Annu Rev Biomed Eng 9:121–167, 2007). Since then there has been an explosion of interest in this hydrated gel-like structure that coats the luminal surface of endothelial cells that line our vasculature due to its important functions in (A) basic vascular physiology and (B) vascular related diseases. This review will highlight the major advances that have occurred since our 2007 paper. Methods A literature search mainly focusing on the role of the glycocalyx in the two major areas described above was performed using electronic databases. Results In part (A) of this review, the new formulation of the century old Starling principle, now referred to as the Michel–Weinbaum glycoclayx model or revised Starling hypothesis, is described including new subtleties and physiological ramifications. New insights into mechanotransduction and release of nitric oxide due to fluid shear stress sensed by the glycocalyx are elaborated. Major advances in understanding the organization and function of glycocalyx components, and new techniques for measuring both its thickness and spatio-chemical organization based on super resolution, stochastic optical reconstruction microscopy (STORM) are presented. As discussed in part (B) of this review, it is now recognized that artery wall stiffness associated with hypertension and aging induces glycocalyx degradation, endothelial dysfunction and vascular disease. In addition to atherosclerosis and cardiovascular diseases, the glycocalyx plays an important role in lifestyle related diseases (e.g., diabetes) and cancer. Infectious diseases including sepsis, Dengue, Zika and Corona viruses, and malaria also involve the glycocalyx. Because of increasing recognition of the role of the glycocalyx in a wide range of diseases, there has been a vigorous search for methods to protect the glycocalyx from degradation or to enhance its synthesis in disease environments. Conclusion As we have seen in this review, many important developments in our basic understanding of GCX structure, function and role in diseases have been described since the 2007 paper. The future is wide open for continued GCX research.

show abstract

“…In vitro and in vivo experimental studies, using cell and animal models is another opportunity of indirect eGC evaluation. This approach was used to study CKD [74,75], cardio-vascular and inflammatory diseases [13,176], cancer [13,176,177]-the conditions manifestating with hypertension, proteinuria, edema, SIR, thrombosis. The results of such studies provide some keys to PE, which is less studied, but exhibits similar clinical signs.…”

Section: Alteration Of Endothelial Glycocalyx In Preeclampsiamentioning

confidence: 99%

Endothelial Dysfunction as a Consequence of Endothelial Glycocalyx Damage: A Role in the Pathogenesis of Preeclampsia

Ziganshina¹,

Yarotskaya²,

Bovin³

et al. 2018

Endothelial Dysfunction - Old Concepts and New Challenges

View full text Add to dashboard Cite

The endothelial glycocalyx is an intravascular compartment which consists of carbohydrate part of membrane glycoconjugates, free proteoglycans and associated proteins. It is thought to play an important role in the vascular tone regulation, vascular permeability and thromboresistance. It was suggested that the leading cause of endothelial dysfunction in various cardiovascular, inflammatory, and kidney diseases is the damage of the endothelial glycocalyx. This review presents the changes in the composition and structure of the endothelial glycocalyx in the settings of damage and under systemic inflammatory response, and the impact of these changes on the functions of endothelial cells and intercellular contacts, mediating the interaction of endothelium and the immune cells. The second issue, discussed in this article is a possible role of endothelial glycocalyx in the pathogenesis of preeclampsia-a complication of pregnancy associated with hypertension, proteinuria and edema. The reviewed data contribute a new insight in the endothelial dysfunction pathogenesis.

show abstract

Endothelial Glycocalyx as Biomarker for Cardiovascular Diseases: Mechanistic and Clinical Implications

Cited by 76 publications

References 106 publications

Factors Enhancing Serum Syndecan-1 Concentrations: A Large-Scale Comprehensive Medical Examination

Factors Enhancing Serum Syndecan-1 Concentrations: A Large-Scale Comprehensive Medical Examination

The Glycocalyx and Its Role in Vascular Physiology and Vascular Related Diseases

Endothelial Dysfunction as a Consequence of Endothelial Glycocalyx Damage: A Role in the Pathogenesis of Preeclampsia

Contact Info

Product

Resources

About