The Glucose Tolerance Test

Baird, J. D.; Duncan, L. J. P.

doi:10.1136/pgmj.35.403.308

Cited by 21 publications

(12 citation statements)

References 45 publications

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“…The rise and fall of the blood glucose concentration following oral or intravenous administration of glucose "the tolerance curve" has long been widely used both clinically in patients and experimentally in animals as an index of efficiency of the mechanisms regulating the concentration of glucose in the blood. 41 The fact that carbohydrate ingestion results in blood glucose fluctuations had actually been known, since the beginning of the 20th century. In 1940 Jerome W. Conn investigated this issue and primarily implemented the GTT in his clinical research, showing that a low-carbohydrate diet can cause deterioration of glucose tolerance.…”

Section: Glucose Tolerance Test (Gtt)mentioning

confidence: 99%

<p>Guidelines and Considerations for Metabolic Tolerance Tests in Mice</p>

Benedé-Ubieto¹,

Estévez-Vázquez²,

Ramadori³

et al. 2020

DMSO

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The epidemic of the century, Diabetes Mellitus (DM) is continuously rising. Intensive research is urgently needed whereby experimental models represent an essential tool to optimise the diagnostic strategy and to improve therapy. In this review, we describe the central principles of the metabolic tests available in order to study glucose and insulin homeostasis in mice, focusing on the most widely usedthe glucose and insulin tolerance tests. We provide detailed experimental procedures as well as the practical implementation of these methods and discuss the main factors that should be taken into account when using this methodology.

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Section: Glucose Tolerance Test (Gtt)mentioning

confidence: 99%

<p>Guidelines and Considerations for Metabolic Tolerance Tests in Mice</p>

Benedé-Ubieto¹,

Estévez-Vázquez²,

Ramadori³

et al. 2020

DMSO

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“…The numerous factors, many unrelated to carbohydrate metabolism, which may influence the oral glucose tolerance curve are well known (Baird & Duncan, 1959). In pregnancy this method of assessing carbohydrate tolerance has the added dis¬ advantages that alterations in gastro-intestinal absorption (Hansen, 1937;Williams, 1941;Hytten & Leitch, 1964) and renal function (Welsh & Sims, 1960) occur.…”

Section: The Diabetogenic Effect Of Pregnancy On the Mothermentioning

confidence: 99%

Some Aspects of Carbohydrate Metabolism in Pregnancy With Special Reference to the Energy Metabolism and Hormonal Status of the Infant of the Diabetic Woman and the Diabetogenic Effect of Pregnancy

Baird¹

1969

Journal of Endocrinology

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“…8 1 5 1 6 Such studies underscore the limitations of both OGTT and IVGTT in detection of abnormality in a given individual. 240 300 -1 4 to -6 -1 4 to -5 -1 6 to -4 6 -8 to -5 3 -2 5 to -5 3 -1 9 to -4 6 -2 5 to -5 6 -2 9 to -1 9 -3 4 to -9 -7 to --7 to 3 -2 4 to 5 -1 8 to -1 1 -2 4 to -4 -1 8 to -4 -8 to 2 -3 to -2 -5 to 1 3 to 18 -1 to 3 In the present study, we compared the variability in OGTT and IVGTT by correlating the mean BG and IRI responses as well as several other parameters of glucose disposal and insulin secretion between the two tests. As stated, these results indicate greater correlation between IVGTTs than between OGTTs.…”

Section: Discussionmentioning

confidence: 99%

Reproducibility and Comparative Analysis of Repeated Intravenous and Oral Glucose Tolerance Tests

et al. 1978

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We have developed a methodology for measuring the reproducibility of the oral glucose tolerance test (OGTT) and the intravenous glucose tolerance test (IVGTT) in normal subjects and in offspring of conjugal diabetic parents. Both groups of subjects revealed more striking correlations of several parameters of blood glucose and insulin secretion between two IVGTTs than between two OGTTs. Employing arbitrary criteria, we calculated a "reproducibility index" as a quantitative measure of blood glucose variability in each subject. No significant difference was found in the reproducibility of OGTT versus IVGTT, nor in normals versus the offspring. Only about 50 per cent of the tests in normals and in the offspring could be considered to be "reproducible." The offspring revealed greater correlations of several parameters, particularly insulin secretion, between the two IVGTTs and between the two OGTTs as compared with the normal group. However, the blood glucose variations tended to be considerably greater in the offspring from one to the other test.

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The Glucose Tolerance Test

Cited by 21 publications

References 45 publications

<p>Guidelines and Considerations for Metabolic Tolerance Tests in Mice</p>

<p>Guidelines and Considerations for Metabolic Tolerance Tests in Mice</p>

Some Aspects of Carbohydrate Metabolism in Pregnancy With Special Reference to the Energy Metabolism and Hormonal Status of the Infant of the Diabetic Woman and the Diabetogenic Effect of Pregnancy

Reproducibility and Comparative Analysis of Repeated Intravenous and Oral Glucose Tolerance Tests

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