Migration is an obvious response to political, economic, socio-demographic, and ecological crises. In recent decades, several crises have occurred in the Mediterranean region; consequently, migration has intensified, the geography of flows has been altered, and the roles of some countries within the Mediterranean migration system have rapidly changed. This paper aims to delineate an overview of migration flows in this region over the last 20 years, focusing on the new migration flows related to humanitarian crises. In doing so, the present study also examines similarities and differences between past and current migration factors that shape the decisions of individuals. Migration flows are closely linked to the needs and fears of European societies. Following this logic, and by analysing challenges related to demographic and geopolitical dimensions in the future scenario, this study discusses the necessity of new policy responses.