The global DNA methylation of mouse oocytes following vitrification

Effect of 5-aza-2′-deoxycytidine on methylation of the putative imprinted control region of H19 during the in vitro development of vitrified bovine two-cell embryos

“…In the past, researchers used common parameters, such as the survival rate and development potential, to assess the efficiency and safety of vitrification (3,4); however, attention is now being paid to the epigenetic modifications induced by vitrification (5)(6)(7). Epigenetic modifications include differential DNA methylation, methylation/acetylation of histones, and production of antisense RNA (8,9).…”