The gingival biopsy in the diagnosis of thrombotic thrombocytopenic purpura

Nishioka, Gary J.; Chilcoat, Charles C.; Aufdemorte, Thomas B.; Clare, Nanette

doi:10.1016/0030-4220(88)90141-7

Cited by 8 publications

(1 citation statement)

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“…However, the diagnostic utility, especially in terms of sensitivity, of the pathological examination in the diagnosis of TTP remains unknown. Nishioka et al and Levine reported similar findings, that biopsies are diagnostic in less than 50% of cases of patients who are diagnosed as having TTP based on clinical features [2,5].…”

Section: Introductionmentioning

confidence: 54%

Thrombotic thrombocytopenic purpura without any evidence of thrombotic lesions at autopsy

Hori

Kami

Hamaki

et al. 2001

Annals of Hematology

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Diagnosis of thrombotic thrombocytopenic purpura (TTP) is usually based upon the clinical features, and does not always involve histopathological evidence. We recently had experience with a patient who developed the five signs characteristic for TTP. He had been treated for liver cirrhosis associated with chronic hepatitis B infection, and the hepatic function was severely impaired at admission. Blood levels of vWF (von Willebrand factor) and factor VIII were highly elevated to 506% and 632%, respectively. These findings suggested severe endothelial damage. Thus, the patient was diagnosed as having TTP secondary to severe hepatic damage, and plasma exchanges were initiated immediately. He responded poorly to the treatment, and finally died of pulmonary hemorrhage. At autopsy, hepatocellular carcinoma was identified in the cirrhotic liver, but it was surprising that thorough postmortem examination failed to show any evidence of thrombotic lesions. Our experience suggests that secondary TTP does not always involve pathological evidence of the thrombotic lesions, and that the formation of thrombi causing vessel occlusion might not be essential in the pathogenesis of some secondary TTP.

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Section: Introductionmentioning

confidence: 54%

Thrombotic thrombocytopenic purpura without any evidence of thrombotic lesions at autopsy

Hori

Kami

Hamaki

et al. 2001

Annals of Hematology

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The Oral Cavity and Lips

Scully

2004

Rook's Textbook of Dermatology

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Dermatoses of the Oral Cavity and Lips

Scully¹

2016

Rook's Textbook of Dermatology, Ninth Edition

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Oral and labial lesions are usually the result of local disease but may be the early signs of systemic disease, including dermatological disorders, and in some instances may cause the main symptoms. This chapter mainly discusses disorders of the periodontal and mucosal tissues that may be related to skin disease and that may present at a dermatology clinic. It should be borne in mind that the professionals most competent in diagnosing and treating oral diseases are those with formal dental training and who are therefore in a position to understand the full complexities of the region. This chapter is divided into a brief discussion of the biology of the mouth, an overview of the more common signs and symptoms affecting specific oral tissues, discussion of the disorders of the oral mucosa of most relevance to dermatology and a tabulated review of oral manifestations of systemic diseases. Only the more classic oral lesions are illustrated. For reasons of space restrictions, diseases affecting the teeth, salivary glands, jaws or temporomandibular joints are not discussed in any depth.

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The gingival biopsy in the diagnosis of thrombotic thrombocytopenic purpura

Cited by 8 publications

References 50 publications

Thrombotic thrombocytopenic purpura without any evidence of thrombotic lesions at autopsy

Thrombotic thrombocytopenic purpura without any evidence of thrombotic lesions at autopsy

The Oral Cavity and Lips

Dermatoses of the Oral Cavity and Lips

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