The GI Cocktail is no more effective than plain liquid antacid: a randomized, double blind clinical trial

Gastrointestinal Distress in Pregnancy

“…Antacids such as aluminum/ magnesium/simethicone formulations (Mylanta) or calcium carbonate (TUMS) can decrease the discomfort and are considered safe in pregnancy as long as women do not exceed the recommended doses and do not take 5 Rey et al, 6 Ali and Egan L, 7 Malfertheiner et al, 8 Wertli et al, 9 Kolnick et al, 10 Berman et al, 11 Majithia and Johnson, 12 and Anderka et al 13 b Efficacy of nonpharmacologic remedies has not been demonstrated in clinical trials. Antacids such as aluminum/ magnesium/simethicone formulations (Mylanta) or calcium carbonate (TUMS) can decrease the discomfort and are considered safe in pregnancy as long as women do not exceed the recommended doses and do not take 5 Rey et al, 6 Ali and Egan L, 7 Malfertheiner et al, 8 Wertli et al, 9 Kolnick et al, 10 Berman et al, 11 Majithia and Johnson, 12 and Anderka et al 13 b Efficacy of nonpharmacologic remedies has not been demonstrated in clinical trials.…”

“…Antacids such as aluminum/ magnesium/simethicone formulations (Mylanta) or calcium carbonate (TUMS) can decrease the discomfort and are considered safe in pregnancy as long as women do not exceed the recommended doses and do not take 5 Rey et al, 6 Ali and Egan L, 7 Malfertheiner et al, 8 Wertli et al, 9 Kolnick et al, 10 Berman et al, 11 Majithia and Johnson, 12 and Anderka et al 13 b Efficacy of nonpharmacologic remedies has not been demonstrated in clinical trials. 11 If women find that antacids are no longer working or that they need to take them with increasing frequency, histamine 2 antagonists such as ranitidine (Zantac) or famotidine (Pepcid) are the next treatment options and are considered safe (category B) for the treatment of GERD in pregnancy. 10 Gastrointestinal cocktails in which viscous lidocaine (Xylocaine) and sometimes phenobarbital (Donnatal) are added have not been shown to be more effective than antacid alone; therefore, there is no benefit to adding additional medication exposure during pregnancy.…”

Comparison of intravenous pantoprazole and ranitidine in patients with dyspepsia presented to the emergency department: a randomized, double blind, controlled trial

“…Berman et al [6] also found no difference between anti-acids, anti-acids+spasmolytics and anti-acids+ spasmolytics+oral lidocaine combinations in ceasing dyspepsia at 30 minutes. Vilke et al [12] compared benzocaine (n=44) and lidocaine (n=38) in patients with dyspepsia, and found that after administration of oral anti-acids and oral anti-cholinergics there was no difference between the two groups at 30 minutes.…”

“…[5] There is also little known about the effectiveness of PPIs and H 2 RAs in patients with dyspepsia presented to the emergency department (ED). [6,7] This study aimed to compare pantoprazole, a PPI, and ranitidine, a H 2 RA, in ceasing dyspeptic symptoms in the ED.…”

Antacid Monotherapy Is More Effective in Relieving Epigastric Pain Than in Combination With Lidocaine: A Randomized Double‐blind Clinical Trial

“…Thirty minutes was chosen to match previous studies, and it was expected to be sufficient time for the analgesia to take effect. 3,4 The predetermined minimum clinically important difference was a 13-mm decrease on a 100-mm visual analog scale (VAS) from baseline. 5 Secondary outcomes were medication palatability (taste, bitterness, texture, and overall acceptability) using a VAS and change in pain score 60 minutes postadministration.…”