Antacid Monotherapy Is More Effective in Relieving Epigastric Pain Than in Combination With Lidocaine: A Randomized Double‐blind Clinical Trial

Abstract

After reading the article, participants should be able to discuss effectiveness of antacid monotherapy for epigastric pain. Activity Disclosures This activity received no commercial support. CME Editor Corey Heitz discloses no relevant financial relationships. This activity underwent peer review in line with standards of editorial integrity and publication ethics. Conflicts of interest have been identified and resolved in accordance with John Wiley and Sons, Inc.'s Policy on Activity Disclosure and Conflict of Interest. Accreditation John Wiley and Sons, Inc. is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

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“…In these patients, it is important to rule out underlying cardiovascular causes. 10 Methods: A double-blind RCT (N = 89) compared the effect of antacid alone with an antacid-lidocaine 2% solution and an antacid-lidocaine 2% viscous gel on epigastric pain symptoms in patients presenting to the emergency department (mean age of 41 years, 64% female, 21% with previous gastroesophageal reflux disease or peptic ulcer disease; mean baseline pain score on a 100-mm visual analogue scale [VAS] was 66). A minimum clinically important difference was set at a 13-mm decrease on the VAS.…”

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“…Réponse : Chez les patients se présentant à l'urgence avec des douleurs épigastriques ou une dyspepsie, les antiacides seuls procuraient un soulagement semblable de la douleur par rapport à une combinaison d'antiacides et de lidocaïne, et ils étaient de texture plus agréable. Il importe d'exclure des causes cardiovasculaires sousjacentes chez de tels patients 10 .…”

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