The German Research Network on Depression and Suicidality

Pfeiffer, Tim; Bauer, Florian; Hegerl, Ulrich

doi:10.1080/13811110590512813

Cited by 10 publications

(3 citation statements)

References 5 publications

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“…Due to our design, we compared two different patient groups but not applying pre- versus post-suicide attempt measures on an individual basis. Patients with a recent suicide attempt occurring less than 3 months before their participation in this study (SA early) were recruited from five centers (Luebeck, Dresden, Berlin, Bonn, Nuremburg) participating in “The German Research Network on Depression” [ 49 ]. Patients recruited from these centres had participated in a randomised double-blind placebo controlled-trial conducted to investigate the anti-suicidal effect of lithium in patients with affective disorders (a lithium-intervention study).…”

Section: Methodsmentioning

confidence: 99%

Personality differences in early versus late suicide attempters

et al. 2016

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BackgroundSuicidality is an individual behaviour caused by a complex framework of internal and external factors. The predictive values of personality traits for a suicide attempt have been demonstrated, especially in conjunction with Cloninger’s TCI and impulsivity. Two issues remain unsolved, namely whether these traits alter over time after a suicide attempt, and how they may be influenced by depressive symptoms.MethodsWe studied two patient cohorts: one sample of 81 patients after a suicide attempt no longer than 3 months previously (SA early) and another sample of 32 patients whose attempt had taken place more than 6 months previously (SA late). We carried out structured interviews with these subjects addressing diagnosis (MINI), suicidality (Scale for suicide ideation), depression (HAMD-17), temperament and character inventory (TCI), and impulsivity (BIS-10). Data analysis was done using SPSS 16.0.ResultsOur two groups did not differ significantly in sociodemographics or suicidality. However, patients in the SA early group were significantly more depressed (p < 0.001), and scored lower in reward dependence (p < 0.001) and persistence (p = 0.005) but higher in harm avoidance (p < 0.001); they did not differ significantly in impulsivity (p < 0.01). Reward dependence, persistence, and harm avoidance remained significantly different between the two groups after controlling for depressive symptoms.ConclusionsOur findings suggest that some personality traits vary after a suicide attempt. Further investigations are necessary to verify our results, ideally in longitudinal studies with larger, carefully-described cohorts. It would be also clinically important to investigate the influence of therapeutic strategies on the variability of personality traits and their impact on suicidal behavior.

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Section: Methodsmentioning

confidence: 99%

Personality differences in early versus late suicide attempters

et al. 2016

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“…The study sample consisted of individuals who had attempted suicide within the foregoing 3 months. Initially, individuals were identified in the emergency department following a suicide attempt at one of the five participating study centres (University of Schleswig‐Holstein, Campus Luebeck; Technical University of Dresden; University of Bonn; Charité University Berlin, Campus Benjamin Franklin; Klinikum Nuremberg Nord) which cooperated within ‘The German Research Network on Depression’ (23). Potential participants were identified during the initial routine examination at the emergency department and through screening newly admitted in‐patients at the psychiatric departments of the respective study centres.…”

Section: Methodsmentioning

confidence: 99%

Adjunctive lithium treatment in the prevention of suicidal behaviour in depressive disorders: a randomised, placebo‐controlled, 1‐year trial

Lauterbach¹,

Felber²,

Müller‐Oerlinghausen³

et al. 2008

Acta Psychiatr Scand

135

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“…1). Nach wie vor machen Suizide mit "älteren" Substanzen wie Doxepin und anderen trizyklischen Antidepressiva einen wesentlichen Anteil aus [25]. So liegt die Suizidrate für Doxepin bei 7,3 pro 10.000 therapierten Patienten pro Jahr [18].…”

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Intoxikation mit einem trizyklischen Antidepressivum

et al. 2007

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A 48-year-old woman with a major depression and treatment with doxepin was found comatose in her flat. Her son last saw her 48 h prior to being found. On arrival of the emergency physician, she presented a generalized seizure. The patient underwent endotracheal intubation and mechanical ventilation due to respiratory insufficiency and severe cyanosis. Empty packages of tablets (doxepin ca. 4000 mg and zolpidem 100 mg) were found in the flat. On hospital admission the doxepin blood concentration was 1.2 microg/ml. No life-threatening arrhythmia occurred at any time. On the advice of the poison information center, hemoperfusion was performed for extracorporeal elimination. Within several hours the doxepin blood concentration could be lowered to 0.8 microg/ml and although still above the therapeutic range the patient was extubated. However, the patient developed a generalized seizure which required re-intubation. As a consequence of the high distribution volume and re-distribution phenomena, the doxepin blood concentration had increased again to 1.2 microg/ml. Approximately 72 h later she was extubated again while the doxepin blood concentration was 0.9 microg/ml and 3 days later, the doxepin blood concentration was lowered to 0.3 microg/ml and the patient was transferred to the psychiatric ward the following day. This case report questions the efficacy of hemoperfusion during acute doxepin intoxication in the given constellation of a non-life-threatening arrhythmia.

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The German Research Network on Depression and Suicidality

Cited by 10 publications

References 5 publications

Personality differences in early versus late suicide attempters

Personality differences in early versus late suicide attempters

Adjunctive lithium treatment in the prevention of suicidal behaviour in depressive disorders: a randomised, placebo‐controlled, 1‐year trial

Intoxikation mit einem trizyklischen Antidepressivum

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