Despite the fact that the loss of biodiversity continues to be an unresolved problem at a global level, it is possible to identify new alternatives and initiatives in biodiversity conservation. From the environmental strategic framework created worldwide, an important World Network of Biosphere Reserves has been implemented under UNESCO's Man and the Biosphere (MAB) Programme, which in the European Union in general, and in Spain in particular, is strongly interrelated with Natura 2000 network that is created under Directive 92/43/EEC. In the present work, the importance of the Spanish Atlantic region for biodiversity is assessed, contextualizing the networks of protected areas created in this territory and valuing the created synergies that have favored the start-up of projects and agreements aimed at reducing the loss of biodiversity and achieving sustainability.