The genus Nonomuraea: A review of a rare actinomycete taxon for novel metabolites

Abstract

The genus Nonomuraea is a rare actinomycete taxon with a long taxonomic history, while its generic description was recently emended. The genus is less known among the rare actinomycete genera as its taxonomic position was revised several times. It can be found in diverse ecological niches, while most of its member species were isolated from soil samples. However, new trends to discover the genus in other habitats are increasing. Generic abundance of the genus was found to be dependent on geographical changes. Novel sources together with selective and invented isolation techniques might increase a chance to explore the genus and its novel candidates. Interestingly, some of its members have been revealed as a valuable source of novel metabolites for medical and industrial purposes. Broad-range of potent bioactive compounds including antimicrobial, anticancer, and antipsychotic substances, broad-spectrum antibiotics and biocatalysts can be synthesized by the genus. In order to investigate biosynthetic pathways of the bioactive compounds and self-resistant mechanisms to these compounds, the links from genes to metabolites have yet been needed for further discovery and biotechnological development of the genus Nonomuraea.

Nonomuraea sp. ATCC 55076 harbours the largest actinomycete chromosome to date and the kistamicin biosynthetic gene cluster

“…3). 27 This marks the first complete genome sequence for a member of the genus Nonomuraea . The largest actinobacterial genome to date is that of Streptomyces bingchinggensis at 11.9 Mbp and 10 023 open reading frames (ORFs) 28.…”

The complete 12 Mb genome and transcriptome of Nonomuraea gerenzanensis with new insights into its duplicated “magic” RNA polymerase

“…The genus Nonomuraea is a rare actinomycete taxon with a long taxonomic history, while its generic description was recently emended 2 . The genus presently comprises more than 30 species that are widely distributed in soil, freshwater and marine environments with several strains recently isolated from acidic soils, rhizosphere, phyllosphere, coastal sediments and extreme or very changeable environments such as sand dunes and mangroves.…”

“…Beside their ecological role, the genus Nonomuraea has a great potential for biotechnological applications. A broad range of potent bioactive compounds including antimicrobial, anticancer, and antipsychotic substances, and a broad spectrum of antibiotics and biocatalysts can be synthesized by the genus 2 . Notwithstanding these perspectives, genomic information about the genus Nonomuraea is, at present, still limited.…”

Classification of Nonomuraea sp. ATCC 39727, an actinomycete that produces the glycopeptide antibiotic A40926, as Nonomuraea gerenzanensis sp. nov.

“…The A40926-producing strain was originally classified as a member of the genus Actinomadura (Goldstein et al, 1987) on the basis of morphology and cell-wall composition, and later assigned to the genus Nonomuraea on the basis of 16S rRNA gene sequence analysis (Monciardini & Sosio, 2004). According to a recent review on the genus Nonomuraea (Sungthong & Nakaew, 2015), strain ATCC 39727 is still considered a poorly taxonomically characterized strain, notwithstanding its pharmaceutical relevance as the producer of A40926 Marcone et al, 2010Marcone et al, , 2014. In this study, we performed a polyphasic taxonomic analysis of strain ATCC 39727, and propose that it represents a novel species of the genus Nonomuraea.…”