The genus Bifidobacterium: from genomics to functionality of an important component of the mammalian gut microbiota

Alessandri, Giulia; Sinderen, Douwe van; Ventura, Marco

doi:10.1016/j.csbj.2021.03.006

Cited by 62 publications

(64 citation statements)

References 206 publications

(210 reference statements)

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“…Later, they were included in the family Lactobacillaceae (Lactobacillus bifidum) until 1924, when L. bifidum was reclassified as the new genus Bifidobacterium by Orla-Jensen [4]. The genus Bifidobacterium belongs to the phylum Actinobacteria and currently comprises 94 recognized (sub)species; most of them are normal inhabitants of the gastro-intestinal tract of humans and animals [5]. They are strictly anaerobic, although some species tolerate moderate oxygen levels [6].…”

Section: The Genus Bifidobacterium: a Landmark Of The Healthy Breastfed Infantmentioning

confidence: 99%

“…The genus comprises high G+C Gram-positive, non-spore-forming, non-motile, and non-filamentous polymorphic rod-shaped bacteria, which can show a large variety of branchings, with bifurcated or spatulated cellular ends being the most common shapes [7]. During recent years, this genus has been extensively studied due to both its important role within the human intestinal microbiota and the extensive use of certain Bifidobacterium strains as probiotic products [5,[8][9][10].…”

Section: The Genus Bifidobacterium: a Landmark Of The Healthy Breastfed Infantmentioning

confidence: 99%

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Role of Bifidobacteria on Infant Health

et al. 2021

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Bifidobacteria are among the predominant microorganisms during infancy, being a dominant microbial group in the healthy breastfed infant and playing a crucial role in newborns and infant development. Not only the levels of the Bifidobacterium genus but also the profile and quantity of the different bifidobacterial species have been demonstrated to be of relevance to infant health. Although no definitive proof is available on the causal association, reduced levels of bifidobacteria are perhaps the most frequently observed alteration of the intestinal microbiota in infant diseases. Moreover, Bifidobacterium strains have been extensively studied by their probiotic attributes. This review compiles the available information about bifidobacterial composition and function since the beginning of life, describing different perinatal factors affecting them, and their implications on different health alterations in infancy. In addition, this review gathers exhaustive information about pre-clinical and clinical studies with Bifidobacterium strains as probiotics in neonates.

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Section: The Genus Bifidobacterium: a Landmark Of The Healthy Breastfed Infantmentioning

confidence: 99%

Section: The Genus Bifidobacterium: a Landmark Of The Healthy Breastfed Infantmentioning

confidence: 99%

Role of Bifidobacteria on Infant Health

et al. 2021

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“…Bifidobacteria constitute up to 37% of the infant gut microbiota in early life [16] . Along with Veillonella, Streptococcus, Citrobacter, Escherichia, as well as Bacteroides and Clostridium, they dominate the core infant gut microbiome [17] . In Table 1, we summarize the characteristics and functions of these pioneering microbes in the infant gut.…”

Section: Core Infant Gut Microbiomementioning

confidence: 99%

First encounters of the microbial kind: perinatal factors direct infant gut microbiome establishment

Dempsey¹,

Ryan²,

Ross³

et al. 2022

MRR

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The human gut microbiome harbors a diverse range of microbes that play a fundamental role in the health and well-being of their host. The early-life microbiome has a major influence on human development and long-term health. Perinatal factors such as maternal nutrition, antibiotic use, gestational age and mode of delivery influence the initial colonization, development, and function of the neonatal gut microbiome. The perturbed early-life gut microbiome predisposes infants to diseases in early and later life. Understanding how perinatal factors guide and shape the composition of the early-life microbiome is essential to improving infant health. The following review provides a synopsis of perinatal factors with the most decisive influences on initial microbial colonization of the infant gut.

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“…Bacterial extracellular appendages, such as pili or fimbriae, are long and non-flagellar structures strategically localized to the cell surface to promote bacterial adhesion in the gut, simultaneously impacting microbehost dialogue [38,39] . In the Bifidobacterium genus, SD pili (types I and II), collectively representing the SD fimbriome, as well as type IV pili, have been previously described [26] .…”

Section: Extracellular Structures Involved In Microbe-host Interactionsmentioning

confidence: 99%

The Integrated Probiotic Database: a genomic compendium of bifidobacterial health-promoting strains

Tarracchini¹,

Viglioli²,

Lugli³

et al. 2022

MRR

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Background: The World Health Organization defines probiotics as “live microorganisms, which when administered in adequate amounts confer a health benefit on the host”. In this framework, probiotic strains should be regarded as safe for human and animal consumption, i.e., they should possess the GRAS (generally recognized as safe) status, notified by the local authorities. Consistently, strains of selected Bifidobacterium species are extensively used as probiotic agents to prevent and ameliorate a broad spectrum of human and/or animal gastrointestinal disorders. Even though probiotic properties are often genus- or species-associated, strain-level differences in the genetic features conferring individual probiotic properties to commercialized bifidobacterial strains have not been investigated in detail. Methods: In this study, we built a genomic database named Integrated Probiotic DataBase (IPDB), whose first iteration consists of common bifidobacterial strains used in probiotic products for which public genome sequences were available, such as members of B. longum subsp. longum, B. longum subsp. infantis, B. bifidum, B. breve, and B. animalis subsp. lactis taxa. Furthermore, the IPDB was exploited to perform comparative genome analyses focused on genetic factors conferring structural, functional, and chemical features predicted to be involved in microbe-host and microbe-microbe interactions. Results and conclusion: Our analyses revealed strain-level genetic differences, underlining the importance of inspecting the strain-specific and outcome-specific efficacy of probiotics. In this context, IPDB represents a valuable resource for obtaining genetic information of well-established bifidobacterial probiotic strains.

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The genus Bifidobacterium: from genomics to functionality of an important component of the mammalian gut microbiota

Abstract: Graphical abstract

Cited by 62 publications

References 206 publications

Role of Bifidobacteria on Infant Health

Role of Bifidobacteria on Infant Health

First encounters of the microbial kind: perinatal factors direct infant gut microbiome establishment

The Integrated Probiotic Database: a genomic compendium of bifidobacterial health-promoting strains

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