The Genotypes of IL-1 beta and MMP-3 are Associated with the Prognosis of HCV-related Hepatocellular Carcinoma

Okamoto, Kinya; Ishida, Chihiro; Ikebuchi, Yuichiro; Mandai, Mari; Mimura, K.; Murawaki, Yoshikazu; Yuasa, Isao

doi:10.2169/internalmedicine.49.3268

Cited by 57 publications

(52 citation statements)

References 47 publications

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“…Okamoto et al (2010) observed a positive relationship between MMP-9 T carriers and poor HCC differentiation, but could not demonstrate a significant relationship between MMP-9 -1562 C/T genotypes with either the development or prognosis of HCC. MMP-9 mRNA levels in HCC tissue are frequently up-regulated through the activation of the PI3K, AKT, and nuclear factor-κB pathways and are correlate to HCC capsular infiltration (Chen et al, 2009).…”

Section: Discussioncontrasting

confidence: 62%

“…For example, MMP-9 cleaves plasminogen to generate angiostatin, one of the most potent inhibitors of angiogenesis (Vairaktaris et al, 2008). HCC is a highly vascular solid tumor in which angiogenesis plays an important role, therefore raising the hypothesis that the 2 main MMP-9 functions, the degradation of the ECM and angiogenesis inhibition, induce a complicated transition in the balance in HCV-related HCC (Okamoto et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Allele T produced 2 bands of 247 and 188 bp, whereas the C allele remained intact. Agarose gel electrophoresis revealed 3 patterns: normal genotype CC with 435-bp frag ments, heterozygous mutated genotype CT with 435-, 247-, and 188-bp fragments, and homo zygous mutated genotype CC with 247-and 188-bp fragments (Okamoto et al, 2010).…”

Section: Dna Extraction and Investigation Of The -1562 C/t Polymorphimentioning

confidence: 99%

“…Hepatocellular carcinoma (HCC) is the fifth most common tumor and the third most common cause of cancer-related deaths worldwide (Okamoto et al, 2010). Carcinogenesis of HCC is a multistep and complex process, and it is known that multiple risk factors, including chronic hepatitis B virus (HBV) or HCV infection, cirrhosis, carcinogen exposure, and a variety of single nucleotide polymorphisms, contribute to hepatocarcinogenesis .…”

Section: Introductionmentioning

confidence: 99%

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Matrix metalloproteinase-9 gene polymorphism in hepatocellular carcinoma patients with hepatitis B and C viruses

Samanoudy¹,

Monir²,

Badawy³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide. In Egypt, the incidence of HCC has doubled over the last decade. Matrix metalloproteinase-9 (MMP-9) plays a key role in cancer invasion and metastasis by degrading the extracellular matrix and basement membrane barriers. A cytosine (C)/ thymidine (T) single nucleotide polymorphism at position -1562 in the MMP-9 promoter is reported to influence the expression of the MMP-9 gene. The association between MMP-9 gene polymorphisms and HCC patients with hepatitis C and B viruses (HCV and HBV) was examined in 91 patients with HCC and viral hepatitis (55 HCV and 36 HBV). The results were compared with those of 42 HCC patients without viral hepatitis and 60 healthy individuals with no liver infection. Polymorphisms of the MMP-9 gene were investigated by polymerase chain reaction amplification followed by restriction fragment length polymorphism analysis. The serum MMP-9 level was quantitatively determined using a human MMP-9 enzyme-linked immunosorbent assay, which showed that homozygosity of the MMP-9 promoter (TT) was more frequent in patients with HCC and chronic HCV or HBV infection when compared with the control group (49.1, 52.8, and 35.7%, respectively). In addition, we observed significant elevation of serum MMP-9 levels in all HCC groups compared to controls. It was concluded that patients with the MMP-9 TT genotype are at risk of developing HCC and HBV or HCV. People with significantly elevated serum levels of MMP-9 are at risk of developing HCC.

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Section: Discussioncontrasting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Section: Dna Extraction and Investigation Of The -1562 C/t Polymorphimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Matrix metalloproteinase-9 gene polymorphism in hepatocellular carcinoma patients with hepatitis B and C viruses

Samanoudy¹,

Monir²,

Badawy³

et al. 2014

Genet. Mol. Res.

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show abstract

“…In 2005, Okamoto and his colleagues reported that the 2G allele of MMP1 promoter 1607 polymorphism was not associated with risk of HCC, compared with the 1G allele in a Japanese population with only 92 HCC cases and 83 controls (16). In 2010, the same group further proposed that IL-1β -31 T allele and MMP-3 5A allele, but not MMP-1 allele, are cooperative risk factors for poor prognosis in HCC patients (23). Zhai and colleagues reported that MMP1 promoter 1607 polymorphism was not associated with risk of HCC in 434 cases and 480 controls in south China (24).…”

mentioning

confidence: 99%

The Contribution of Matrix Metalloproteinase-1 Genotypes to Hepatocellular Carcinoma Susceptibility in Taiwan

Lai

Gong

et al. 2017

CGP

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NOD‐like receptor C4 Inflammasome Regulates the Growth of Colon Cancer Liver Metastasis in NAFLD

Ohashi¹,

Wang

Yang

et al. 2019

Hepatology

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Nonalcoholic fatty liver disease (NAFLD) enhances the growth and recurrence of colorectal cancer (CRC) liver metastasis. With the rising prevalence of NAFLD, a better understanding of the molecular mechanism underlying NAFLD‐associated liver metastasis is crucial. Tumor‐associated macrophages (TAMs) constitute a large portion of the tumor microenvironment that promotes tumor growth. NOD‐like receptor C4 (NLRC4), a component of an inflammasome complex, plays a role in macrophage activation and interleukin (IL)‐1β processing. We aimed to investigate whether NLRC4‐mediated TAM polarization contributes to metastatic liver tumor growth in NAFLD. Wild‐type and NLRC4‐/‐ mice were fed low‐fat or high‐fat diet for 6 weeks followed by splenic injection of mouse CRC MC38 cells. The tumors were analyzed 2 weeks after CRC cell injection. High‐fat diet–induced NAFLD significantly increased the number and size of CRC liver metastasis. TAMs and CD206‐expressing M2 macrophages accumulated markedly in tumors in the presence of NAFLD. NAFLD up‐regulated the expression of IL‐1β, NLRC4, and M2 markers in tumors. In NAFLD, but not normal livers, deletion of NLRC4 decreased liver tumor growth accompanied by decreased M2 TAMs and IL‐1β expression in tumors. Wild‐type mice showed increased vascularity and vascular endothelial growth factor (VEGF) expression in tumors with NAFLD, but these were reduced in NLRC4‐/‐ mice. When IL‐1 signaling was blocked by recombinant IL‐1 receptor antagonist, liver tumor formation and M2‐type macrophages were reduced, suggesting that IL‐1 signaling contributes to M2 polarization and tumor growth in NAFLD. Finally, we found that TAMs, but not liver macrophages, produced more IL‐1β and VEGF following palmitate challenge. Conclusion: In NAFLD, NLRC4 contributes to M2 polarization, IL‐1β, and VEGF production in TAMs, which promote metastatic liver tumor growth.

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The Genotypes of IL-1 beta and MMP-3 are Associated with the Prognosis of HCV-related Hepatocellular Carcinoma

Cited by 57 publications

References 47 publications

Matrix metalloproteinase-9 gene polymorphism in hepatocellular carcinoma patients with hepatitis B and C viruses

Matrix metalloproteinase-9 gene polymorphism in hepatocellular carcinoma patients with hepatitis B and C viruses

The Contribution of Matrix Metalloproteinase-1 Genotypes to Hepatocellular Carcinoma Susceptibility in Taiwan

NOD‐like receptor C4 Inflammasome Regulates the Growth of Colon Cancer Liver Metastasis in NAFLD

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