The Contribution of Matrix Metalloproteinase-1 Genotypes to Hepatocellular Carcinoma Susceptibility in Taiwan

Lai, Yu‐Hung; Gong, Chi Li; Fu, Chun Kai; Yueh, Te Cheng; Tsai, Chia Wen; Chang, Wen Shin; Hsiao, Chieh Lun; Yen, Shiou Ting; Li, Hsin Ting; Jeng, Long Bin; Wang, Shou Cheng; Bau, Da Tian

doi:10.21873/cgp.20024

Cited by 19 publications

(10 citation statements)

References 46 publications

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“…The results showed that overexpression of FOXP3 in HepG2 cells upregulated the expression of MMP-1. Furthermore, the migration and invasion ability of HCC cells were observed to increase after knocking down FOXP3, supported by the findings that overexpressed MMP-1 was associated with an elevated metastasis capacity, invasion and migration ability of the HCC cells ( 35 , 36 ). Base on the result, we concluded that FOXP3 in HCC cells promotes the metastasis of HCC through the regulation of the expression of MMP-1.…”

Section: Discussionsupporting

confidence: 55%

FOXP3 expression in FOXP3+ tumor cells promotes hepatocellular cells metastasis

Zhang¹,

Chen²,

Liao³

et al. 2020

Transl Cancer Res TCR

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Background: Forkhead transcription factor 3 (FOXP3) is a key molecule for the development of regulatory T cell. Recent studies showed that FOXP3 was also expressed in tumor cells. This study is designed to identify the expression of FOXP3 and its pathogenesis in hepatocellular carcinoma (HCC).Methods: Through immunohistochemistry, RNA extraction and Real-Time Quantitative PCR, western blot analysis, transwell cell migration assay and invasion assays, and in vivo experiment, we detected FOXP3 expression in HCC and analyzed the expression of tumor metastasis-related genes in HCC cells using female BALB/c-Nude mice.Results: The results showed that FOXP3 was expressed in partial HCC tissues samples and cell lines.The distant metastasis rate was remarkably higher in the FOXP3 positive HCCs than that in the negative group. The positive rate of FOXP3 expression in the metastatic HCC was higher than that in primary HCC, and the expression level of FOXP3 was found to increase as the enhancement in the metastatic potential of the cell lines. Furthermore, in HCC cell lines, FOXP3 overexpression can promote the cell metastasis and invasion by regulating MMP-1. The in vivo experiment showed that the proliferation ability of HepG2 cells in nude mice increased significantly after FOXP3 was overexpressed, and the incidence rate of lung metastasis in MHCC97L cells was significantly deceased after knocking down the FOXP3 expression.Conclusions: Our findings support that partial HCC tissues and cell lines expressing FOXP3 can promote the metastasis by regulating MMP-1.

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Section: Discussionsupporting

confidence: 55%

FOXP3 expression in FOXP3+ tumor cells promotes hepatocellular cells metastasis

Zhang¹,

Chen²,

Liao³

et al. 2020

Transl Cancer Res TCR

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“…MMP-1 is also named collagenase-1, due to the fact that it promotes degradation of the interstitial collagens and is normally regulated by TIMP-1. Overexpression of both MMP-1 and TIMP-1 is associated with an elevated invasive and migratory capacity of the HCC cells, most likely by ECM degradation in the process of EMT [42]. Overexpression of miR-526b is associated with increased cell proliferation, venous infiltration, and a poor prognosis, and MMP-1 is recognized as a direct target of miR-526b [43].…”

Section: Mmps With a Demonstrated Role In The Emt Of Invasive Hccmentioning

confidence: 99%

The Role of Matrix Metalloproteinases in the Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma

Scheau

Bădărău

Costache

et al. 2019

Analytical Cellular Pathology

263

219

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The epithelial-mesenchymal transition (EMT) is a transformation process mandatory for the local and distant progression of many malignant tumors, including hepatocellular carcinoma (HCC). Matrix metalloproteinases (MMPs) play significant roles in cellular regeneration, programmed death, angiogenesis, and many other essential tissular functions, involved in the normal development and also in pathological processes, such as the EMT. This paper reviews the roles of MMPs in the EMT involved in HCC invasion, as well as the ancillary roles that MMP cross-activation and tissue inhibitors play in modulating this process. While gelatinases MMP-2 and MMP-9 are the MMPs commonly cited in the EMT of HCC, MMPs belonging to other classes have been proven to be involved in this process, favoring not only invasion and metastasis (MMP-1, MMP-3, MMP-7, MMP-10, MMP-11, MMP-13, MMP-14, MMP-16, MMP-26, and MMP-28) but also angiogenesis (MMP-8 and MMP-10). There is also data suggesting that other MMPs with a suspected or demonstrated role in the EMT of other cancers may also have some degree of involvement in HCC. The auto- and cross-activation of MMPs may complicate this issue, as pinpointing the extent of implication of each MMP may be extremely difficult. The homeostasis between MMPs and their tissue inhibitors is essential in preventing tumor progression, and the disturbance of this stability is another entailed factor in the EMT of HCC, which is addressed herein.

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“…MMP-2 together with MMP-9, are the two most common progression markers correlated with invasion and metastasis in various tumor, especially HCC 15 , 16 . Although MMP1 has been more commonly reported to be expressed in non-neoplastic liver tissues 17 , it has also been shown to be associated with invasion and migration in HCC by extracellular matrix (ECM) degradation in the epithelial-mesenchymal transition (EMT) 18 . MMP1 can be expressed with a low positive rate under normal conditions in a wide range of cells including stromal fibroblasts, macrophages, endothelial cells and epithelial cells.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive bioinformatic analysis of MMP1 in hepatocellular carcinoma and establishment of relevant prognostic model

Dai

Mugaanyi

Cai

et al. 2022

Sci Rep

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Matrix metalloproteinase 1 (MMP1) encodes endopeptidases associated with degradation of multiple components of the extracellular matrix. This function has increasingly been considered to play a major proteolysis role in tumor invasion and metastasis. However, the relationship between MMP1 gene expression, tumor-immune microenvironment and prognosis in hepatocellular carcinoma patients remains mostly unclear. This study focused on a comprehensive analysis of MMP1 in hepatocellular carcinoma, specifically the prognosis and tumor-immune microenvironment. MMP1 expression was analyzed using TCGA database and clinical samples. MMP1 associated mechanisms, pathways, mutations and prognosis in hepatocellular carcinoma were evaluated. We also analyzed the tumor-immune microenvironment and corresponding treatments. Our research demonstrated that MMP1 expression was upregulated in patients with hepatocellular carcinoma and correlated with poor survival. A prognostic model was established and its performance evaluated. We also found and report various correlations between MMP1 and immune-related cells/genes, as well the potential therapeutic agents. These findings indicate that MMP1 can potentially be a promising prognostic biomarker and indicator of the tumor-immune microenvironment status in hepatocellular carcinoma.

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The Contribution of Matrix Metalloproteinase-1 Genotypes to Hepatocellular Carcinoma Susceptibility in Taiwan

Abstract: Abstract. Background

Cited by 19 publications

References 46 publications

FOXP3 expression in FOXP3+ tumor cells promotes hepatocellular cells metastasis

FOXP3 expression in FOXP3+ tumor cells promotes hepatocellular cells metastasis

The Role of Matrix Metalloproteinases in the Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma

Comprehensive bioinformatic analysis of MMP1 in hepatocellular carcinoma and establishment of relevant prognostic model

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