The genomics of selection in dogs and the parallel evolution between dogs and humans

Wang, Guodong; Zhai, Weiwei; Yang, Hongshan; Fan, Ruoxi; Cao, Xue; Zhong, Li; Wang, Lu; Liu, Fei; Wu, Hong; Cheng, Lu-Guang; Poyarkov, Andrei D.; Poyarkov, N.A.; Tang, Shusheng; Zhao, Wenming; Gao, Yun; Lv, Xue-mei; Irwin, David M.; Savolainen, Peter; Wu, Chung‐I; Zhang, Yaping

doi:10.1038/ncomms2814

Cited by 284 publications

(288 citation statements)

References 57 publications

Supporting

Mentioning

259

Contrasting

Unclassified

Order By: Relevance

“…These results can provide the support for a genetic role in human-animal interaction. Wang et al (2013) insisted parallel selection in humans and dogs, and our results could be considered in line with that conclusion. (b) Subtest Touch Sensitivity (TS) and Stability (S) were significantly different between ages.…”

Section: Discussionsupporting

confidence: 80%

Personality consistency analysis in cloned quarantine dog candidates

et al. 2017

View full text Add to dashboard Cite

In recent research, personality consistency has become an important characteristic. Diverse traits and human-animal interactions, in particular, are studied in the field of personality consistency in dogs. Here, we investigated the consistency of dominant behaviours in cloned and control groups followed by the modified Puppy Aptitude Test, which consists of ten subtests to ascertain the influence of genetic identity. In this test, puppies are exposed to stranger, restraint, prey-like object, noise, startling object, etc. Six cloned and four control puppies participated and the consistency of responses at ages 7-10 and 16 weeks in the two groups was compared. The two groups showed different consistencies in the subtests. While the average scores of the cloned group were consistent (P = 0.7991), those of the control group were not (P = 0.0089). Scores of Pack Drive and Fight or Flight Drive were consistent in the cloned group, however, those of the control group were not. Scores of Prey Drive were not consistent in either the cloned or the control group. Therefore, it is suggested that consistency of dominant behaviour is affected by genetic identity and some behaviours can be influenced more than others. Our results suggest that cloned dogs could show more consistent traits than non-cloned. This study implies that personality consistency could be one of the ways to analyse traits of puppies. Canine behaviour, cloned dog, puppy aptitude testMuch effort has been made to assess the personalities of dogs to predict the temperaments of companion animals and to select working dogs more efficiently. Potential dog owners likely want to know their family member's expected characteristics. Bartlett (1979) explained how to select a family dog using the Puppy Aptitude Test. Adopting suitable animals could be the beginning of a happy life for both owners and the dogs. Breeders need to check the puppies' temperaments for similar reasons for their future dog owners. Training institutions that produce excellent working dogs focused on selecting candidates at an early age to save money and time. Svartberg et al. (2005) investigated the consistency of dogs' behaviours using a standardized behavioural test and could deduce stable traits such as playfulness, chase-proneness and sociability. Substantial consistency of dogs' personalities was reported by Fratkin et al. (2013), who determined the factors that influence consistency as the age, interaction between temperament and age, and length of time interval between tests. These authors did not, however, estimate the influence of the genetic background on consistency (Fratkin et al. 2013). Bartlett (1979) used 10 subtests to analyse puppies' behaviours, including social attraction, dominant or submissive tendency under stress, willingness to work with humans and sensitivities. Volhard and Volhard (2001) divided the subtests into three drives,

show abstract

Section: Discussionsupporting

confidence: 80%

Personality consistency analysis in cloned quarantine dog candidates

et al. 2017

View full text Add to dashboard Cite

show abstract

“…This finding is not a surprise and is consistent with the rapid evolution of genes in the nervous systems of other domestic animals, which has collectively been attributable to behavioral shifts that accompany domestication [14][15][16][17][18]. In addition, functional enrichment analysis of genes in regions with the top 1% XP-EHH scores revealed that many candidate genes related to the npg www.cell-research.com | Cell Research nervous system were over-represented in the following Human Phenotype Ontology (HPO) categories: abnormality of the nervous system (31 genes), abnormality of the central nervous system (30 genes), and cognitive impairment (25 genes) (P < 0.05) (Supplementary information, Table S8).…”

Section: Positively Selected Genes In Domestic Chickens Compared Withsupporting

confidence: 68%

“…Dogs also harbor weaker visual acuity compared to their wild ancestors, however, in contrast to chickens, there was no evidence for positive selection in visionrelated genes in previous studies [14][15][16]. Vision is important in birds for survival [58], but other sensory abilities including hearing and smell, might play more important roles in mammals.…”

Section: Discussionmentioning

confidence: 90%

Positive selection rather than relaxation of functional constraint drives the evolution of vision during chicken domestication

Wang

Zhang

et al. 2016

Cell Res

Self Cite

View full text Add to dashboard Cite

As noted by Darwin, chickens have the greatest phenotypic diversity of all birds, but an interesting evolutionary difference between domestic chickens and their wild ancestor, the Red Junglefowl, is their comparatively weaker vision. Existing theories suggest that diminished visual prowess among domestic chickens reflect changes driven by the relaxation of functional constraints on vision, but the evidence identifying the underlying genetic mechanisms responsible for this change has not been definitively characterized. Here, a genome-wide analysis of the domestic chicken and Red Junglefowl genomes showed significant enrichment for positively selected genes involved in the development of vision. There were significant differences between domestic chickens and their wild ancestors regarding the level of mRNA expression for these genes in the retina. Numerous additional genes involved in the development of vision also showed significant differences in mRNA expression between domestic chickens and their wild ancestors, particularly for genes associated with phototransduction and photoreceptor development, such as RHO (rhodopsin), GUCA1A, PDE6B and NR2E3. Finally, we characterized the potential role of the VIT gene in vision, which experienced positive selection and downregulated expression in the retina of the village chicken. Overall, our results suggest that positive selection, rather than relaxation of purifying selection, contributed to the evolution of vision in domestic chickens. The progenitors of domestic chickens harboring weaker vision may have showed a reduced fear response and vigilance, making them easier to be unconsciously selected and/or domesticated.

show abstract

“…El perro doméstico ha acompañado al hombre desde hace 33 mil años (1) , y desde entonces los procesos de domesticación y coevolución (2) han llevado a la casi indefectible presencia de perros en cualquier área donde se asiente un grupo humano. Estas poblaciones de perros cargan sus propios patógenos, entre los que se encuentran aquellos adaptados para transmitirse a los humanos y que se les denomina agentes zoonóticos (3) .…”

Section: Introductionunclassified

Efecto del sacrificio de perros vagabundos en el control de la rabia canina

Castillo-Neyra¹,

Levy

Náquira

2016

Rev Peru Med Exp Salud Publica

View full text Add to dashboard Cite

RESUMENEn la ciudad de Arequipa, Perú, se han detectado perros con rabia desde marzo de 2015, señal de la reintroducción del virus de la rabia (VR) en esta zona previamente declarada libre de esta enfermedad. La alta densidad de perros vagabundos ha sido considerada una de las causas de la continua transmisión del VR en el brote de la ciudad de Arequipa, alentando el sacrificio de perros como medida de salud pública. Sin embargo, la efectividad de esta medida de control no ha sido evaluada. El objetivo de esta revisión fue determinar la efectividad del sacrificio de perros vagabundos como medida de control de la rabia urbana. Se realizó la búsqueda de artículos sobre control de rabia canina o urbana en las bases de datos de Medline, Scopus y LILACS. Se incluyeron estudios originales y revisiones que hayan evaluado algún efecto del sacrificio de perros en la transmisión del VR. Veinte de 21 artículos concluyen que el sacrificio de perros vagabundos es inefectivo en reducir la trasmisión del VR e, incluso, puede tener consecuencias imprevistas que empeoren el problema. En conclusión, la evidencia disponible indica que sacrificar perros vagabundos no es efectivo para controlar la rabia urbana. Además, las diversas consecuencias negativas del sacrificio de los perros vagabundos reportadas en otras partes del mundo sugieren que el sistema de rabia urbana es altamente complejo y todos sus componentes deben ser tomados en cuenta durante la implementación de actividades de control. Palabras clave: perros; rabia; sacrificio de perros; zoonosis (fuente: DeCS BIREME). EFFECT OF FREE-ROAMING DOGS CULLING ON THE CONTROL OF CANINE RABIES ABSTRACTIn the Peruvian city of Arequipa, rabid dogs have been detected since March 2015, signaling the reintroduction of the rabies virus (RV) in this previously officially-declared rabies free zone. High dog density is considered one of the causes for the continuous transmission of the RV in the outbreak in the city of Arequipa, which seemingly lends support to the culling of dogs as a public health measure. However, the effectiveness of culling free-roaming dogs to control urban rabies has not been evaluated. Objective to determine the effectiveness of free-roaming dog culling as a control measure of urban rabies. Source of data: We searched for articles on dog rabies control or urban rabies control in the databases of PubMed, Scopus and LILACS. The characteristics and results of the documents obtained were recorded. Eligibility criteria: We included original studies and reviews that have evaluated an effect of culling dogs in the transmission of RV. Data collection and evaluation: One of the authors (RCN) screened the articles found in the search based on their titles and abstracts. The data and results of the articles selected for full reading were evaluated by at least two authors. Results: 21 articles were eligible for full reading. 20 of 21 articles conclude that free-roaming dog culling is ineffective in reducing the transmission of RV and may even have unintended consequences that w...

show abstract

The genomics of selection in dogs and the parallel evolution between dogs and humans

Cited by 284 publications

References 57 publications

Personality consistency analysis in cloned quarantine dog candidates

Personality consistency analysis in cloned quarantine dog candidates

Positive selection rather than relaxation of functional constraint drives the evolution of vision during chicken domestication

Efecto del sacrificio de perros vagabundos en el control de la rabia canina

Contact Info

Product

Resources

About