The genomic ancestry of Jat Sikh population from Northwest India inferred from 15 autosomal STR markers using capillary electrophoresis

Kakkar, Sonia; Shrivastava, Pankaj; Mandal, Shatrughan Prasad; Preet, Kiran; Kumawat, R. K.; Chaubey, Gyaneshwer

doi:10.1080/03014460.2020.1772877

Cited by 4 publications

(2 citation statements)

References 27 publications

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“…Detection and estimation of STR markers' frequency is a preliminary step for various populations/subpopulations or different countries prior to their use in various applications. Different countries have conducted such studies including the USA [40,41], Turkey [42], China [43][44][45], Mexico [46], India [47], and Lybia [48]. For example, the Federal Bureau of Investigation (FBI) selected 13 autosomal STR loci for use in forensic cases and named them the Combined DNA Index System (CODIS).…”

Section: Introductionmentioning

confidence: 99%

The Impact of Leukemia on the Detection of Short Tandem Repeat (STR) Markers

Alharbi¹,

Alamri²,

El-Shehawi³

2022

Cureus

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Introduction: Short tandem repeats (STRs) have been used for various identity typing methods worldwide. They have high discrimination power in human identification in forensics, paternity testing, missed personal identification, genetic diseases, and gene regulatory functions. They have also been used to detect and monitor the stability of diseases, including various types of cancer. This study aimed to investigate the impact of leukemia on the detection and stability of STR markers.Methods: DNA was isolated from 30 participants (15 with chronic myeloid leukemia( CML) and 15 healthy controls) and used to amplify STR markers using specific primers.Results: We found that the blood of those with leukemia had more 9.3 and 9 alleles at the tyrosine hydroxylase 1 (TH01) marker than the blood of the healthy control samples. The results of this study will help researchers understand leukemia's effect on the detection and stability of STR markers in leukemic patients compared to healthy individuals. Conclusion:Our results demonstrate that STR markers could become useful in genetic studies of leukemia cases.

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Section: Introductionmentioning

confidence: 99%

The Impact of Leukemia on the Detection of Short Tandem Repeat (STR) Markers

Alharbi¹,

Alamri²,

El-Shehawi³

2022

Cureus

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“…While traditionally considered unrelated to human phenotypes, recent genome-wide studies have shown that tandem repeat mutations can contribute to the development of certain diseases, such as autism [11,12]. Additionally, studies have linked STRs to gene expression levels and human traits [13,14]. To explore the potential association between STR loci and facial similarity among family members, we conducted a genetic association analysis.…”

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confidence: 99%

Unveiling facial kinship: The BioKinVis dataset for facial kinship verification and genetic association studies

Yu,

Jin,

et al. 2023

Electrophoresis

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Facial image–based kinship verification represents a burgeoning frontier within the realms of computer vision and biomedicine. Recent genome‐wide association studies have underscored the heritability of human facial morphology, revealing its predictability based on genetic information. These revelations form a robust foundation for advancing facial image–based kinship verification. Despite strides in computer vision, there remains a discernible gap between the biomedical and computer vision domains. Notably, the absence of family photo datasets established through biological paternity testing methods poses a significant challenge. This study addresses this gap by introducing the biological kinship visualization dataset, encompassing 5773 individuals from 2412 families with biologically confirmed kinship. Our analysis delves into the distribution and influencing factors of facial similarity among parent–child pairs, probing the potential association between forensic short tandem repeat polymorphisms and facial similarity. Additionally, we have developed a machine learning model for facial image–based kinship verification, achieving an accuracy of 0.80 in the dataset. To facilitate further exploration, we have established an online tool and database, accessible at http://120.55.161.230:88/.

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