The genetics of type 2 diabetes

Ahlqvist, Emma; Groop, Leif

doi:10.1002/9781118387658.ch26

Cited by 4 publications

(4 citation statements)

References 102 publications

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“…C-peptide levels are considered to be a critical indicator of the efficacy of novel therapies for T2D. Since genetic and environmental risk factors are involved in human T2D, transplantation of endogenous or exogenous stem cells may be beneficial for patients with diabetes (42,43). A number of studies have suggested that bone marrow cells (BMCs) and mesenchymal stem cells (MSCs) are able to differentiate into islet β-cells and influence their regeneration in diabetic animals (23,44,45).…”

Section: Discussionmentioning

confidence: 99%

Therapeutic efficacy of umbilical cord-derived mesenchymal stem cells in patients with type 2 diabetes

Guan

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. Type 2 diabetes (T2D) is characterized by progressive and inexorable β-cell dysfunction, leading to insulin deficiency. Novel strategies to preserve the remaining β-cells and restore β-cell function for the treatment of diabetes are urgently required. Mesenchymal stem cells (MSCs) have been exploited in a variety of clinical trials aimed at reducing the burden of immune-mediated disease. The aim of the present clinical trial was to assess the safety and efficacy of umbilical cord-derived MSC (UCMSC) transplantation for patients with T2D. The safety and efficacy of UCMSC application were evaluated in six patients with T2D during a minimum of a 24-month follow-up period. Following transplantation, the levels of fasting C-peptide, the peak value and the area under the C-peptide release curve increased significantly within one month and remained high during the follow-up period (P<0.05). Three of the six patients became insulin free for varying lengths of time between 25 and 43 months, while the additional three patients continued to require insulin injections, although with a reduced insulin requirement. Fasting plasma glucose and 2-h postprandial blood glucose levels were relatively stable in all the patients following transplantation. There was no immediate or delayed toxicity associated with the cell administration within the follow-up period. Therefore, the results indicated that transplantation of allogeneic UCMSCs may be an approach to improve islet function in patients with T2D. There were no safety issues observed during infusion and the long-term monitoring period.

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Section: Discussionmentioning

confidence: 99%

Therapeutic efficacy of umbilical cord-derived mesenchymal stem cells in patients with type 2 diabetes

Guan

et al. 2015

Experimental and Therapeutic Medicine

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“…For example, a recent study of Middle Eastern immigrants in Sweden found that the immigrants had a two to threefold higher risk of type 2 diabetes than native Swedes (22). In sum, there are many factors, from changes in activity and nutrition patterns to genetic predisposition that are likely to contribute to the high prevalence of type 2 diabetes in the GCC countries.…”

Section: Genetic Predisposition For Diabetesmentioning

confidence: 99%

The curse of wealth – Middle Eastern countries need to address the rapidly rising burden of diabetes

Klautzer

Becker

Mattke

2014

Int J Health Policy Manag

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“…As a result, the misuse of SGLT2 inhibitors in autoimmune diabetes can pose a high risk to develop euDKA, as the present case illustrated. Interestingly, our case had severe metabolic acidosis (pH 6.972 and HCO3 1.5 mmol/L) along with borderline hyperglycemia (blood glucose 242 mg/dL) [12][13][14][15]. These extremely discordant data had not been reported in patients with T1DM yet.…”

Section: Case Reportmentioning

confidence: 53%

Dilemma on Classifying Diabetes Mellitus in Adolescence: A Case Report and Review of Literature

Chiang¹,

Wu²,

Chen³

et al. 2017

J Clin Case Rep

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Diabetic ketoacidosis (DKA) is one of the most serious complications of diabetes mellitus (DM) that is prone to occur in children with type 1 DM (T1DM). We report a 17-year-old overweight girl who was treated with multiple oral antihyperglycemic drugs under the initial impression of type 2 DM (T2DM). Nevertheless, severe euglycemic DKA happened after the additional prescription of sodium-glucose cotransporter 2 inhibitors for two months. Consequently, T1DM was diagnosed on the basis of insulinopenic status in glucagon test and the presence of islet autoantibodies. This case highlighted the importance of precise classification before diabetes treatment in adolescence. A literature review is aimed to help clinicians differentiate various types of DM more specifically in clinical practice.

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The genetics of type 2 diabetes

Cited by 4 publications

References 102 publications

Therapeutic efficacy of umbilical cord-derived mesenchymal stem cells in patients with type 2 diabetes

Therapeutic efficacy of umbilical cord-derived mesenchymal stem cells in patients with type 2 diabetes

The curse of wealth – Middle Eastern countries need to address the rapidly rising burden of diabetes

Dilemma on Classifying Diabetes Mellitus in Adolescence: A Case Report and Review of Literature

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