The genetics of obsessive compulsive disorder: A review of the evidence

Pauls, David L.

doi:10.1002/ajmg.c.30168

Cited by 167 publications

(148 citation statements)

References 67 publications

Supporting

Mentioning

136

Contrasting

Unclassified

Order By: Relevance

“…A number of twin (van Grootheest et al, 2005) and family (Black et al, 1992;Do RosarioCampos et al, 2005;Hanna et al, 2005;van Grootheest et al, 2005;Nicolini et al, 2009;Pauls, 2010) studies indicate that genetic factors contribute to its aetiology. The environment has also been found to play a role in the development of the disorder e twin studies indicate that approximately 50% of individual variation in OCD is due to nongenetic, environmental factors (Samuels, 2009).…”

Section: Introductionmentioning

confidence: 99%

BDNF Val66Met modifies the risk of childhood trauma on obsessive-compulsive disorder

Hemmings

Löchner

Merwe

et al. 2013

Journal of Psychiatric Research

View full text Add to dashboard Cite

Abstract:Childhood trauma has been linked to the development of later psychopathology, including obsessive-compulsive disorder (OCD). Although evidence exists to suggest that genetic and environmental factors are involved in the aetiology of OCD, little attention has been paid to the interactions that exist between genes and environment. The aim of this study was to investigate gene-byenvironment interactions between childhood trauma and the BDNF Val66Met variant in patients with OCD.Childhood trauma was assessed in 134 OCD patients and 188 controls using the Childhood Trauma Questionnaire (CTQ). Linear regression models were used for statistical analyses. Geneeenvironment interactions were estimated by including a combined genotype and CTQ score in the models as interaction terms. All analyses were adjusted for age, gender, CTQ minimisation-denial score and home language by including them in the logistic regression models as covariates.Childhood trauma, specifically emotional abuse and neglect, increased the odds of having OCD significantly (p < 0.001). Although no significant association was observed between BDNF Val66Met and the development of OCD, interaction analysis indicated that the BDNF Met-allele interacted with childhood emotional abuse to increase the risk of OCD significantly in a dose-dependent manner (p < 0.024). To our knowledge, this is one of the first studies to investigate geneeenvironment interactions in OCD, and the findings indicate the importance of collating genetic and environmental variables in future studies.

show abstract

Section: Introductionmentioning

confidence: 99%

BDNF Val66Met modifies the risk of childhood trauma on obsessive-compulsive disorder

Hemmings

Löchner

Merwe

et al. 2013

Journal of Psychiatric Research

View full text Add to dashboard Cite

show abstract

“…114 Although the etiology of OCD remains unknown, the results of twin studies, familial studies, and segregation analysis have provided evidence that OCD has a strong genetic component. [115][116][117][118][119] Some investigators have also found markers of oxidative stress in the brain tissues of patients with OCD. [120][121][122] Moreover, Kuloglu et al 120 showed significantly lower levels of vitamin E and C, and higher levels of malondialdehyde (MDA) in patients with OCD compared to controls, suggesting that OCD is linked to oxidative stress.…”

Section: Obsessive-compulsive Disordermentioning

confidence: 99%

Mitochondria and the central nervous system: searching for a pathophysiological basis of psychiatric disorders

Streck

Gonçalves

Furlanetto

et al. 2014

Rev. Bras. Psiquiatr.

View full text Add to dashboard Cite

Introduction: Mitochondrial dysfunction has been postulated to participate in the development of many neuropsychiatric disorders, but there is no consensus as to its role. The aim of this paper is to review recent studies and to outline the current understanding of the association between mitochondrial dysfunction and psychiatric disorders. Methodology: We reviewed articles that evaluated mitochondrial dysfunction and psychiatric disorders, with a particular focus on depression, bipolar disorder, anxiety disorders, obsessivecompulsive disorder, and autism spectrum disorder, and the association between mitochondrial dysfunction and development of these disorders. Results: Evidence suggests that alterations in mitochondrial morphology, brain energy metabolism, and mitochondrial enzyme activity may be involved in the pathophysiology of different neuropsychiatric disorders, given their key role in energy metabolism in the cell. Conclusions: Understanding the interactions between mitochondrial dysfunction and development of psychiatric disorders may help establish more effective therapeutic strategies for these disorders and thus lead to better outcomes for affected subjects.

show abstract

“…Like other psychiatric disorders, such as schizophrenia or bipolar disorder, OCD is etiologically heterogeneous, involving contributions of both genetic and environmental factors (Geller & March, 2012;Koran & Blair Simpson, 2013;Pauls, 2008;Stewart & Pauls, 2010). Heritability estimates for childhood onset OCD range from 45% to 65% (van Grootheest, Cath, Beekman, & Boomsma, 2005).…”

Section: Introductionmentioning

confidence: 99%

Obsessive‐Compulsive Disorder: The Process of Parental Adaptation and Implications for Genetic Counseling

Andrighetti

Semaka

Stewart

et al. 2015

Journal of Genetic Counseling

View full text Add to dashboard Cite

Obsessive-compulsive disorder (OCD) has primarily pediatric onset and well-documented unique impacts on family functioning. Limited research has assessed the understanding that parents of children with OCD have of the etiology of the condition, and there are no data regarding potential applications of genetic counseling for this population. We recruited 13 parents of 13 children diagnosed with OCD from the OCD Registry at British Columbia Children's Hospital, and conducted qualitative semi-structured telephone interviews to explore participants' experiences with their child's OCD, causal attributions of OCD, and perceptions of two genetic counseling vignettes. Interviews were audio-recorded, transcribed, and analyzed using elements of grounded theory qualitative methodology. Analysis revealed key components and contextual elements of the process through which parents adapt to their child's OCD. This adaptation process involved conceptualizing the meaning of OCD, navigating its impact on family dynamics, and developing effective illness management strategies. Adaptation took place against a backdrop of stigmatization and was shaped by participants' family history of mental illness and their child's specific manifestations of OCD. Parents perceived genetic counseling, as described in the vignettes, as being empowering, alleviating guilt and blame, and positively impacting treatment orientation. These data provide insight into the process of parental adaptation to pediatric OCD, and suggest that genetic counseling services for families affected by OCD may help facilitate adaptation to this illness.

show abstract

The genetics of obsessive compulsive disorder: A review of the evidence

Cited by 167 publications

References 67 publications

BDNF Val66Met modifies the risk of childhood trauma on obsessive-compulsive disorder

BDNF Val66Met modifies the risk of childhood trauma on obsessive-compulsive disorder

Mitochondria and the central nervous system: searching for a pathophysiological basis of psychiatric disorders

Obsessive‐Compulsive Disorder: The Process of Parental Adaptation and Implications for Genetic Counseling

Contact Info

Product

Resources

About