The Genetics of Diabetic Nephropathy

Abstract

Up to 40% of patients with type 1 and type 2 diabetes will develop diabetic nephropathy (DN), resulting in chronic kidney disease and potential organ failure. There is evidence for a heritable genetic susceptibility to DN, but despite intensive research efforts the causative genes remain elusive. Recently, genome-wide association studies have discovered several novel genetic variants associated with DN. The identification of such variants may potentially allow for early identification of at risk patients. Here we review the current understanding of the key molecular mechanisms and genetic architecture of DN, and discuss the merits of employing an integrative approach to incorporate datasets from multiple sources (genetics, transcriptomics, epigenetic, proteomic) in order to fully elucidate the genetic elements contributing to this serious complication of diabetes.

Association of Diabetes Related Complications with Heart Rate Variability among a Diabetic Population in the UAE

“…Oxidative stress and inflammation are considered as the main causative factors of diabetes complications including renal, retinal vascular and neurological impairments [2, 3]. However, the mechanisms for the development of diabetic related complications are most likely multifactorial and involve in addition to oxidative stress and inflammation, environmental and lifestyle factors, as well as genetic predisposition [4].…”

Eighty years on insulin and ‘going strong’

“…Long‐term monitoring of glycaemic control by HbA 1c has been made readily available along with improved patient education, self‐monitoring of blood glucose, insulin treatment with basal‐bolus concept, insulin pens and continuous subcutaneous insulin infusion with insulin pumps . Several randomised clinical trials have demonstrated that improved glycaemic control reduces the development of retinopathy and nephropathy . Today the information and resources that are available to patients who are diagnosed with type 1 diabetes are vast compared with the 1930s.…”

Type 2 diabetes mellitus: Clinical aspects of genetics, nutrigenetics, and pharmacogenetics

“…В настоящее время про-должаются исследования по выявлению генов-кандидатов разви-тия и быстрого прогрессирования диабетической нефропатии, невропатии и ретинопатии [26][27][28][29].…”