The genetic variant C825T of the beta 3 subunit of G protein is associated with hypertension in a Portuguese population

Sousa, A C; Reis, Roberto Palma dos; Pereira, Andreia; Borges, S; Gouveia, Sara; Spínola, Adelaide; Freitas, Ana Isabel; Guerra, G; Góis, Teresa; Rodrigues, M; Henriques, E; Ornelas, I; Freitas, Carolina; Pereira, Décio; Brehm, António; Mendonça, Maria Isabel

doi:10.1016/j.repce.2017.09.018

Cited by 4 publications

(3 citation statements)

References 42 publications

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“…Since 1998, an association between the C825T polymorphism of GNB3 and risk of hypertension has been confirmed by multiple studies in various populations 9,33‐36 . Specifically, hypertension shares a pathophysiology similar to that of PE, and pregestational hypertension is a precursor of PE 37 .…”

Section: Discussionmentioning

confidence: 94%

“…Since 1998, an association between the C825T polymorphism of GNB3 and risk of hypertension has been confirmed by multiple studies in various populations. 9,[33][34][35][36] Specifically, hypertension shares a pathophysiology similar to that of PE, and pregestational hypertension is a precursor of PE. 37 Moreover, the C825T polymorphism has been associated with obesity, metabolic syndrome, arteriosclerosis, depression, and insulin resistance, which might independently or interactively increase the risk of PE.…”

Section: Ta B L E 2 Meta-analysis For the Association Between The Gnb...mentioning

confidence: 99%

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Meta‐analysis of the genetic association between maternal GNB3 C825T polymorphism and risk of pre‐eclampsia

Song

Huang

Zhou

et al. 2021

Intl J Gynecology & Obste

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Background The relationship between the C825T polymorphism of GNB3 (encoding G‐protein β3 subunit) and pre‐eclampsia risk is unclear. Objective To systematically explore the association between GNB3 C825T and pre‐eclampsia. Search strategy PubMed, EMBASE, Google Scholar, and Chinese National Knowledge Infrastructure (CNKI) databases were searched to September 1, 2020, using keywords including “GNB3 C825T” and “pre‐eclampsia”. Selection criteria Case–control and cohort studies investigating the relationship between GNB3 C825T polymorphism and pre‐eclampsia were included. Data collection and analysis Two reviewers collected the data independently and calculate odds ratios (ORs) with 95% confidence intervals (CIs). Main results The meta‐analysis involved eight studies from seven publications, including 2071 cases and 3419 controls. Overall analysis showed that GNB3 C825T was associated with increased pre‐eclampsia risk in the recessive model (OR, 1.21; 95% CI, 1.01–1.44; P = 0.04). Subgroup analysis stratified by Hardy–Weinberg equilibrium revealed a relationship between GNB3 C825T and increased risk of pre‐eclampsia in the allelic (OR, 1.66; 95% CI, 1.34–2.05; P < 0.001), homozygous (OR, 2.12, 95% CI, 1.04–4.32; P = 0.04), dominant (OR, 1.91; 95% CI, 1.18–3.11; P = 0.009), and recessive (OR, 1.70; 95% CI, 1.03–2.81; P = 0.04) models. Conclusions Maternal GNB3 C825T polymorphism seems to be a risk factor for pre‐eclampsia.

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Section: Discussionmentioning

confidence: 94%

Section: Ta B L E 2 Meta-analysis For the Association Between The Gnb...mentioning

confidence: 99%

Meta‐analysis of the genetic association between maternal GNB3 C825T polymorphism and risk of pre‐eclampsia

Song

Huang

Zhou

et al. 2021

Intl J Gynecology & Obste

View full text Add to dashboard Cite

show abstract

“…One study supported the association between ACE and hypertension [55]. Three studies on GNB3 [58][59][60], which was reported to be associated with hypertension but with an undefined salt sensitivity phenotype in the previous review, did not fit our criteria. We identified 20 genes with some evidence for association with hypertension or SSBP [19,54,55,.…”

Section: Utility Of Genetics In Identifying Hypertensives With Ssbpmentioning

confidence: 90%

Challenges and Approach to Identifying Individuals with Salt Sensitivity of Blood Pressure

Parksook

Williams

2022

Am J Nephrol

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Background: Salt sensitivity of blood pressure (SSBP) is a trait observed in both humans and animals, characterized by an increase in blood pressure (BP) following salt loading or a drop in BP following salt depletion. Summary: This “intermediate” phenotype has been reported in a sizable portion of individuals regardless of their hypertensive status; hypertensives (27-51%), normotensives (18-47%). Further, in epidemiological studies, this phenotype is associated with increased adverse cardiovascular outcomes, risk factors, and reduced survival rates. Here in, we review the challenges in the assessment of SSBP, heterogeneity in the assessment method and protocols, and how these differences could affect the results. Further, we review how to identify individuals with SSBP in the clinic by using clinical and genetic data. No clinical approach has yet provided sufficient sensitivity and specificity to identify those with SSBP. Thus, SSBP is not routinely identified in the clinic. Current genetic data suggest that genotyping may support such an office approach. To date, studies in18 genes have provided sufficient evidence and reproducible data to identify potential mechanisms involved in subsets of subjects with hypertension and SSBP. Key message: Proof-of-concept clinical trials using genetic biomarkers to determine and treat individuals with SSBP are ongoing. Their results will provide critical evidence to support genetic-focused, mechanistically driven algorithms to identify and treat, specifically, individuals with SSBP—personalized medicine.

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Genetic predisposition for essential hypertension, based on studies of genetic polymorphisms in modern global human populations: The perspective of evolutionary biology

Bicho

2018

Revista Portuguesa de Cardiologia

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The genetic variant C825T of the beta 3 subunit of G protein is associated with hypertension in a Portuguese population

Cited by 4 publications

References 42 publications

Meta‐analysis of the genetic association between maternal GNB3 C825T polymorphism and risk of pre‐eclampsia

Meta‐analysis of the genetic association between maternal GNB3 C825T polymorphism and risk of pre‐eclampsia

Challenges and Approach to Identifying Individuals with Salt Sensitivity of Blood Pressure

Genetic predisposition for essential hypertension, based on studies of genetic polymorphisms in modern global human populations: The perspective of evolutionary biology

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