The Genetic structure of Mexican Mestizos of different locations: tracking back their origins through MHC genes, blood group systems, and microsatellites

Association between angiotensin-1 converting enzyme gene polymorphism and the metabolic syndrome in a Mexican population

“…In the Mexican population, mestizas comprise 80% of the total, with 20% corresponding to Mexican Indian groups and a reduced group (less than 1.0%) of a white population formed by inmigrant Europeans (mainly Spanish) and North-Americans (from the United States of America and Canada). A Mexican mestizo has been defined by the National Institute of Anthropology as a person who was born in the country, has a Spanish-derived last name, and a family of Mexican ancestors of at least three generations (Gorodezky et al, 2001). Our results support this hypothesis because a high prevalence of the DD genotype has been reported in previous studies in a Spanish population with nephropathy (Ortiz et al, 2003).…”

Distribution of TAP gene polymorphisms and extended MHC haplotypes in Mexican Mestizos and in Seri Indians from northwest Mexico

“…The only significant ⌬ value found was for TAP1*0401/TAP2*0201 (⌬ = 0.037, P = 0.04) and the most frequent combination was TAP1*0101/02/TAP2*0101 (HF = 39.9%), reflecting the association of the prevalent alleles present in the Mestizos. A bilocus analysis was also done considering the prevalent class II haplotypes described previously 50 in combination first with TAP1 and then with TAP2 alleles (Table 4). Linkage disequilibria between class II and TAP1 in Mestizos showed significant ⌬ values for TAP1* 0401/DQB1*0301-DQA1*0501-DRB1*1602 (⌬ = 0.034, P = 0.004); TAP1*02011/12/DQB1*0201-DQA1*0201-DRB1* 0701 (⌬ = 0.032, P = 0.01); TAP1*02011/12/DQB1*0301-DQA1*0501-DRB1*1602 (⌬ = 0.023, P = 0.04); and the most frequent combinations were TAP1*0101/02/DQB1*0402-DQA1*0401-DRB1*0802 (HF = 12.6%); and TAP1*0101/ 02/DQB1*0302-DQA1*03011-DRB1*0407 (HF = 11.4%).…”

“…49 This was shown by us in a recent paper where we reported the distribution of class II MHC genes in three different populations from Mexico, one of the north, one of the center and one of the highlands of Mexico. 50 The aim of this study was to analyse the genetic profile of TAP1 and TAP2 genes in two different Mexican populations: the Seri and the Mestizos from the highlands of the country. We also incorporated the results of class I and class II MHC typing in order to build extended haplotypes, to add new information on the MHC profile of Mexican populations.…”

Ancestry informative markers and admixture proportions in northeastern Mexico

“…Although the Native American marker M242 (ancestral to P36) could increase this estimation, its low frequency (2.3%) in an earlier report of Amerindians, 31 allows for predicting that our estimation will not change substantially. For the European component, the described Spanish ancestry of the Mexican Mestizos 32 allows for assuming that the Eurasian haplogroups G, I, J and K were received from Spaniard males during and after the Conquest, rather than involving the recent Asian gene flow. Finally, the African component did not include the ancestral African lineages A and B, and was exclusively represented by YAP, related to the Bantu populations from this continent.…”