Ancestry informative markers and admixture proportions in northeastern Mexico

Abstract

To investigate the ancestral admixture in the Mestizo population in northeastern Mexico, we genotyped 74 ancestral informative markers (AIMs) and 15 Y-single-nucleotide polymorphisms (Y-SNPs) in 100 individuals. The Native American contribution is 56% (range: 27.4-81.2%), the European contribution is 38% (range: 16.7-70.5%) and the West African contribution is 6%. The results show a higher European contribution than was reported in other similar studies in the country, albeit with a predominant Native American ancestry. No remarkable differences in the ancestry proportions were observed using subgroups of 74, 54, 34 and 24 AIMs. The paternal lineage calculated by genotyping of 15 Y-SNPs, shows a major component of European and Eurasian ancestry markers (B78%), compared with Amerindian (B12%) and African markers (10%). This information will set a reference for future determinations of admixture proportions in the Mestizo population from Mexico and for populationbased association studies of complex diseases.

Genetic population data of three Y-STR genetic systems in Mexican-Mestizos from Monterrey, Nuevo León (Northeast, Mexico)

“…The position of Monterrey is probably explained by a higher European ancestry than the rest of Mexican-Mestizo populations, which agrees with the previously reported increasing gradient of European ancestry toward the northern region of the Mexican territory [1,4,14]. Previous ancestry estimates from Monterrey based on single nucleotide polymorphisms of the Y-chromosome (Y-SNPs) are compatible with this interpretation [15]. In fact, additional MDS plots performed online (https://yhrd.org/) verified that Monterrey was closer to the European populations than to the rest of Mexican-…”

Admixture and population structure in Mexican-Mestizos based on paternal lineages

“…13,14 Although the Y-STRs used in human identification have been employed to estimate paternal admixture in different Mexican-Mestizo populations, 15 these markers do not constitute the ideal tool for this purpose. 16 Available estimates based on Y-SNPs have been generated from a small number of populations, such as that of Mexico City, 17 and those of the states of Guerrero, 18 Jalisco 13 and Nuevo Leó n. 19 Moreover, with the exception of the latter report on Nuevo Leó n, the remaining studies were restricted to two or three Y-linked biallelic markers; thus, the wide diversity of paternal lineages evaluated by Y-SNPs is relatively unknown throughout the Mexican territory. In this work, we examined 18 Y-SNPs in order to establish a confident landscape of the paternal ancestry in Mestizo populations from different regions of the country.…”

Socioeconomic stress by dopamine receptor 2 gene interactions in the development of obesity

“…One study found that RS1076563, also a DRD2 intron, was associated with smoking in 14 year-olds (Ducci, et al, 2011). Several studies investigated the RS1800498 SNP, also known as Taq1D, as an ancestry marker since it exhibits a significant allelic variety among racial/ethnic groups (Choudhry, et al, 2006;Martinez-Fierro, et al, 2009;Mez, et al, 2009;Saraswathy, et al, 2009). Again linking this genotype to addictive behavior, an association between a haplotype which includes this SNP and alcohol and smoking behavior was identified (Preuss, Zill, Koller, Bondy, & Sokya, 2007).…”