The genetic diversity within the 1.4 kb HLA-G 5′ upstream regulatory region moderately impacts on cellular microenvironment responses

Dias, Fabrício C.; Bertol, Bruna Cristina; Poras, Isabelle; Souto, Bruno M; Mendes-Junior, Celso Teixeira; Castelli, Erick C.; Gineau, Laure; Sabbagh, Audrey; Rouas‐Freiss, Nathalie; Carosella, Edgardo D.; Donadi, Eduardo Antônio; Moreau, Philippe

doi:10.1038/s41598-018-24009-7

Cited by 22 publications

(22 citation statements)

References 62 publications

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“…In the HLA-G locus, the enhancer A (EnhA) region, which allows the interaction with nuclear factor k-light-chain-ehnancer of activated B cells (NF-κB) family of transcription factors, binds only p50/p50 homodimers (63). Moreover, the binding of interferon regulatory factor 1 and 2 (IRF-1 and IRF-2) to interferon-stimulated response element in the HLA-G promoter is not present in HLA-G (64,65). The presence of this unique HLA-G promoter region indicates that HLA-G expression is not influenced by NF-κB or by interferon α (IFN-α), IFN-β, and IFN-γ (Figure 1).…”

Section: Intracellular and Extracellular Mechanisms Regulating Hla-g mentioning

confidence: 99%

HLA-G Genotype/Expression/Disease Association Studies: Success, Hurdles, and Perspectives

Amodio

Gregori

2020

Front. Immunol.

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The non-classical HLA-G is a well-known immune-modulatory molecule. In physiological condition, HLA-G surface expression is restricted to the maternal-fetal interface and to immune-privileged adult tissues, whereas soluble forms of HLA-G are detectable in various body fluids. HLA-G can be de novo expressed in pathological conditions including tumors, chronic infections, or after allogeneic transplantation. HLA-G exerts positive effects modulating innate and adaptive immune responses and promoting tolerance, or detrimental effects inducing immune escape mechanisms. HLA-G locus, in contrast to classical HLA class I gene, is highly polymorphic in the non-coding 3 ′ untranslated region (UTR) and in the 5 ′ upstream regulatory region (5 ′ URR). Variability in these regions influences HLA-G expression by modifying mRNA stability or allowing posttranscriptional regulation in the case of 3 ′ UTR or by sensing the microenvironment and responding to specific stimuli in the case of HLA-G promoter regions (5 ′ URR). The influence of genetic variations on the expression of HLA-G makes it an attractive biomarker to monitor disease predisposition and progression, or response to therapy. Here, we summarize the current knowledge, efforts, and obstacles to generate a general consensus on the correlation between HLA-G genetic variability, protein expression, and disease predisposition. Moreover, we discuss perspectives for future investigation on HLA-G genotype/expression in association with disease predisposition and progression.

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Section: Intracellular and Extracellular Mechanisms Regulating Hla-g mentioning

confidence: 99%

HLA-G Genotype/Expression/Disease Association Studies: Success, Hurdles, and Perspectives

Amodio

Gregori

2020

Front. Immunol.

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“…HLA-G genetic polymorphism could influence HLA-G expression 47,48 and consequently modulate the risk of malaria infection 49 . We have studied the role played by genetic polymorphism of HLA-G 3′UTR regulatory region.…”

Section: Discussionmentioning

confidence: 99%

High level of soluble human leukocyte antigen (HLA)-G at beginning of pregnancy as predictor of risk of malaria during infancy

d’Almeida

Sadissou

Sagbohan

et al. 2019

Sci Rep

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Placental malaria has been associated with an immune tolerance phenomenon and a higher susceptibility to malaria infection during infancy. HLA-G is involved in fetal maternal immune tolerance by inhibiting maternal immunity. During infections HLA-G can be involved in immune escape of pathogens by creating a tolerogenic environment. Recent studies have shown an association between the risk of malaria and HLA-G at both genetic and protein levels. Moreover, women with placental malaria have a higher probability of giving birth to children exhibiting high sHLA-G, independently of their own level during pregnancy. Our aim was to explore the association between the level of maternal soluble HLA-G and the risk of malaria infection in their newborns. Here, 400 pregnant women and their children were actively followed-up during 24 months. The results show a significant association between the level of sHLA-G at the first antenatal visit and the time to first malaria infection during infancy adjusted to the risk of exposure to vector bites (aHR = 1.02, 95%CI [1.01–1.03], p = 0.014). The level of sHLA-G is a significant predictor of the occurrence of malaria infection during infancy consistent with the hypothesis that mother sHLA-G could be a biomarker of malaria susceptibility in children.

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“…Over the recent years, con- * Electronic address: atanunandy1989@gmail.com † Electronic address: amritaphy92@gmail.com siderable attention has been paid to different non-trivial geometries for showing flat band localization with short range fluctuation. Those states are named as compact localized states (CLS) [20]- [27] where wave function amplitude strictly vanishes beyond a finite sub-part of the entire system. One such characteristic cluster is effectively isolated from the others by some selective vertices where there are no permission for the electron to stay.…”

Section: Introductionmentioning

confidence: 99%

Flux modulated flat band engineering in square-kagomé ladder network

Nandy¹,

Mukherjee²

2019

Physics Letters A

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The origin of non-dispersive flat band modes for a quasi-one dimensional square-kagomé ladder network is explored analytically by virtue of the real space renormalization group (RSRG) technique. A section of the eigenstates is non-diffusive i.e., localized within a cluster of sub-lattice sites partly by the destructive type of quantum interference and partly by the physical boundary created by the site with zero wave function amplitude. By making the amplitude vanish at the selective sites it becomes possible to confine the incoming excitation within the trapping cell leading to the formation of compact localized states. The effective mass of the particle becomes infinitely large corresponding to those self-localized modes and hence the mobility of the wave train becomes vanishingly small. This quenched kinetic energy leads to a momentum independent contribution to a dispersion curve. The present analysis is corroborated by numerical calculation of spectral landscape and the corresponding dispersion profile. The application of uniform magnetic flux may lead to a comprehensive engineering of the position as well as the curvature of the band. Also, one-to-one mapping between electronic case and photonic case within the tight-binding framework helps us to study the photonic localization in an analogous single mode wave guide system. The concept of slow light eventually introduces the possibility of spatial compression of light energy.

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The genetic diversity within the 1.4 kb HLA-G 5′ upstream regulatory region moderately impacts on cellular microenvironment responses

Cited by 22 publications

References 62 publications

HLA-G Genotype/Expression/Disease Association Studies: Success, Hurdles, and Perspectives

HLA-G Genotype/Expression/Disease Association Studies: Success, Hurdles, and Perspectives

High level of soluble human leukocyte antigen (HLA)-G at beginning of pregnancy as predictor of risk of malaria during infancy

Flux modulated flat band engineering in square-kagomé ladder network

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