High level of soluble human leukocyte antigen (HLA)-G at beginning of pregnancy as predictor of risk of malaria during infancy

d’Almeida, Tania; Sadissou, Ibrahim; Sagbohan, Mermoz; Milet, Jacqueline; Avokpaho, Euripide Frinel G Arthur; Gineau, Laure; Sabbagh, Audrey; Moutaïrou, Kabirou; Donadi, Eduardo Antônio; Favier, Benoît; Pennetier, Cédric; Baldet, Thierry; Moiroux, Nicolas; Carosella, Edgardo D.; Moreau, Philippe; Rouas‐Freiss, Nathalie; Cottrell, Gilles; Courtin, David; Garcia, André

doi:10.1038/s41598-019-45688-w

Cited by 10 publications

(6 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, the enhanced expression level of sHLA-G was correlated with the increased predisposition to develop human African trypanosomiasis and promoted susceptibility to malaria, suggesting sHLA-G as a prognostic biomarker in such diseases [ 39 , 78 ]. The level of sHLA-G is also a crucial biomarker of the incidence of malaria during infancy and further confirm that mother sHLA-G levels could be considered a diagnostic marker of malaria susceptibility in children [ 95 ]. Moreover, sHLA-G also exerts a critical immune-modulatory function to decrease fetal loss due to toxoplasmosis infection; however, its overexpression could lead to a congenital transmission [ 91 ].…”

Section: Hla-g Expression In Parasitic Diseasesmentioning

confidence: 87%

Immunomodulatory Potential of Non-Classical HLA-G in Infections including COVID-19 and Parasitic Diseases

et al. 2022

View full text Add to dashboard Cite

Human Leukocyte Antigen-G (HLA-G), a polymorphic non-classical HLA (HLA-Ib) with immune-regulatory properties in cancers and infectious diseases, presents both membrane-bound and soluble (sHLA-G) isoforms. Polymorphism has implications in host responses to pathogen infections and in pathogenesis. Differential expression patterns of HLA-G/sHLA-G or its polymorphism seem to be related to different pathological conditions, potentially acting as a disease progression biomarker. Pathogen antigens might be involved in the regulation of both membrane-bound and sHLA-G levels and impact immune responses during co-infections. The upregulation of HLA-G in viral and bacterial infections induce tolerance to infection. Recently, sHLA-G was found useful to identify the prognosis of Coronavirus disease 2019 (COVID-19) among patients and it was observed that the high levels of sHLA-G are associated with worse prognosis. The use of pathogens, such as Plasmodium falciparum, as immune modulators for other infections could be extended for the modulation of membrane-bound HLA-G in COVID-19-infected tissues. Overall, such information might open new avenues concerning the effect of some pathogens such as parasites in decreasing the expression level of HLA-G to restrict pathogenesis in some infections or to influence the immune responses after vaccination among others.

show abstract

Section: Hla-g Expression In Parasitic Diseasesmentioning

confidence: 87%

Immunomodulatory Potential of Non-Classical HLA-G in Infections including COVID-19 and Parasitic Diseases

et al. 2022

View full text Add to dashboard Cite

show abstract

“…In agreement with this scenario, ancestral fetal HLA-G haplotypes showed associations with preeclampsia and stillbirths in our series, thereby supporting their disadvantage in modern environments. Furthermore, high HLA-G expression is associated with higher implantation rates [111] and uneventful pregnancies as presented here, but might confer an increased risk of offspring to malaria and other infections [ 112 , 113 ].…”

Section: Discussionmentioning

confidence: 97%

Fetal HLA-G mediated immune tolerance and interferon response in preeclampsia

et al. 2020

View full text Add to dashboard Cite

Background Fetal immune tolerance is crucial for pregnancy success. We studied the link between preeclampsia, a severe pregnancy disorder with uncertain pathogenesis, and fetal human leukocyte antigen G ( HLA-G ) and other genes regulating maternal immune responses. Methods We assessed sex ratios and regulatory HLA-G haplotypes in population cohorts and series of preeclampsia and stillbirth. We studied placental mRNA expression of 136 genes by sequencing and HLA-G and interferon alpha (IFNα) protein expression by immunohistochemistry. Findings We found underrepresentation of males in preeclamptic births, especially those delivered preterm or small for gestational age. Balancing selection at HLA-G associated with the sex ratio, stillbirth, and preeclampsia. We observed downregulation of HLA-G , its receptors, and many other tolerogenic genes, and marked upregulation of IFNA1 in preeclamptic placentas. Interpretation These findings indicate that an evolutionary trade-off between immune tolerance and protection against infections at the maternal-fetal interface promotes genetic diversity in fetal HLA-G, thereby affecting survival, preeclampsia, and sex ratio. We highlight IFNA1 as a potential mediator of preeclampsia and a target for therapeutic trials. Funding Finnish Medical Foundation, Päivikki and Sakari Sohlberg Foundation, Karolinska Institutet Research Foundation, Scandinavia-Japan Sasakawa Foundation, Japan Eye Bank Association, Astellas Foundation for Research on Metabolic Disorders, Japan Society for the Promotion of Science, Knut and Alice Wallenberg Foundation, Swedish Research Council, Medical Society Liv och Hälsa, Sigrid Jusélius Foundation, Helsinki University Hospital and University of Helsinki, Jane and Aatos Erkko Foundation, Academy of Finland, Finska Läkaresällskapet, Novo Nordisk Foundation, Finnish Foundation for Pediatric Research, and Emil Aaltonen Foundation.

show abstract

“…The present follow-up is part of a study concerning 1,183 pregnant women participating in Malaria in Pregnancy Preventive Alternative Drugs , a randomized trial of intermittent preventive treatment (IPTp) in Benin ( 18 ). The first 154 infants for which flow cytometry data were available were enrolled from January 2010 to June 2011 and followed throughout the first 2 years of life in the TOLIMMUNPAL project ( 19 ). At delivery, active placental malaria was determined by impression smear from the placental blood stained with Giemsa.…”

Section: Methodsmentioning

confidence: 99%

Placental Malaria is Associated with Higher LILRB2 Expression in Monocyte Subsets and Lower Anti-Malarial IgG Antibodies During Infancy

Dechavanne

Nouatin²,

Adamou

et al. 2022

Front. Immunol.

Self Cite

View full text Add to dashboard Cite

BackgroundPlacental malaria (PM) is associated with a higher susceptibility of infants to Plasmodium falciparum (Pf) malaria. A hypothesis of immune tolerance has been suggested but no clear explanation has been provided so far. Our goal was to investigate the involvement of inhibitory receptors LILRB1 and LILRB2, known to drive immune evasion upon ligation with pathogen and/or host ligands, in PM-induced immune tolerance.MethodInfants of women with or without PM were enrolled in Allada, southern Benin, and followed-up for 24 months. Antibodies with specificity for five blood stage parasite antigens were quantified by ELISA, and the frequency of immune cell subsets was quantified by flow cytometry. LILRB1 or LILRB2 expression was assessed on cells collected at 18 and 24 months of age.FindingsInfants born to women with PM had a higher risk of developing symptomatic malaria than those born to women without PM (IRR=1.53, p=0.040), and such infants displayed a lower frequency of non-classical monocytes (OR=0.74, p=0.01) that overexpressed LILRB2 (OR=1.36, p=0.002). Moreover, infants born to women with PM had lower levels of cytophilic IgG and higher levels of IL-10 during active infection.InterpretationModulation of IgG and IL-10 levels could impair monocyte functions (opsonisation/phagocytosis) in infants born to women with PM, possibly contributing to their higher susceptibility to malaria. The long-lasting effect of PM on infants’ monocytes was notable, raising questions about the capacity of ligands such as Rifins or HLA-I molecules to bind to LILRB1 and LILRB2 and to modulate immune responses, and about the reprogramming of neonatal monocytes/macrophages.

show abstract

High level of soluble human leukocyte antigen (HLA)-G at beginning of pregnancy as predictor of risk of malaria during infancy

Cited by 10 publications

References 53 publications

Immunomodulatory Potential of Non-Classical HLA-G in Infections including COVID-19 and Parasitic Diseases

Immunomodulatory Potential of Non-Classical HLA-G in Infections including COVID-19 and Parasitic Diseases

Fetal HLA-G mediated immune tolerance and interferon response in preeclampsia

Placental Malaria is Associated with Higher LILRB2 Expression in Monocyte Subsets and Lower Anti-Malarial IgG Antibodies During Infancy

Contact Info

Product

Resources

About