The genetic basis of insecticide resistance in the house fly: Evidence that a single locus plays a major role in metabolic resistance to insecticides

Xenobiotic response in Drosophila melanogaster: Sex dependence of P450 and GST gene induction

“…Terriere and Yu (1974) suggested that higher induction in resistant fl ies was likely due to (P450) gene amplifi cation, but they rejected induction as a factor in the development of resistance in the fi eld. It was suggested that the same regulatory (trans-acting) gene may be involved in both induction and biochemical resistance (Terriere, 1983), and Plapp (1984) further proposed that a receptor involved in xenobiotic induction may be altered in resistant insects. However, despite growing evidence that overexpression of some P450 genes in resistant strains can involve trans-regulating factors (e.g., Sabourault et al, 2001), a link with induction has remained tenuous.…”

Age‐dependent response to insecticides and enzymatic variation in susceptible and resistant codling moth larvae

“…Despite the measurement of high levels of expression of the GST system, its involvement in permethrin resistance in Aedes aegypti was precluded because pyrethroids were unlikely to constitute a GST substrate (Grant and Matsumura, 1989). Genes encoding for detoxifying enzymes are thought to be coordinately regulated by a single major locus that generate the resistant phenotype (Plapp, 1984). Such an assertion supports the results of Grant and Matsumura (1989), considering (1) the GST system as one of the several loci controlled by a major single locus, on the one October 2002 hand, and (2) close genetic linkages between metabolic resistance mechanisms on the other hand.…”

Enzymes Involved in the Metabolism of Plant Allelochemicals

“…No cytosolic protein receptor from an insect tissue has been found (Denison et al, 1985) or unambiguously characterized (Plapp, 1984).…”