The generation of hydrophilic polypeptide-siloxane conjugates via n-carboxyanhydride polymerisation

Abstract

A novel methodology to create covalently linked polypeptide-siloxane hybrid materials by controlled n-carboxyanhydride ring opening polymerisation is disclosed. Poly-L-glutamic acid and poly-L-lysine conjugated products were formed that possessed excellent surface wettability. In addition, the poly-L-lysine-siloxane hybrids formed demonstrated bactericidal attributes against gram-positive Staphylococcus aureus and gram-negative Escherichia coli. It is anticipated that these materials may be of significance for the generation of hydrophilic siloxane-containing polymers that are commonly employed in contemporary medical devices.

Poly(hydroxy acid) Nanoparticles for the Encapsulation and Controlled Release of Doxorubicin

“…It was envisaged that due to its poly(cationic) nature, poly[(PheLA) 10.4 ‐ b ‐(LysLA) 31.4 ] may be exploited for antimicrobial applications and gene delivery . However, its polycationic nature also dictates that this PHA could pose cytotoxicity problems to healthy cells if it were to be used for drug delivery in vivo .…”

Facile synthesis of 1,4-cis-polyisoprene–polypeptide hybrids with different architectures

“…15,16 All of these methods were later employed for polypeptide hybrids synthesis. 11,[17][18][19][20][21][22][23][24][25][26][27][28][29] Recently, Pahovnik suggested the use of OH-terminated PEO and polystyrene as macroinitiators in the presence of methanesulfonic acid which could catalyze the addition of the first monomeric units and protonate the terminal generated NH2-group, preventing the propagation to occur. 30 After complete initiation, propagation was started by addition of a tertiary amine that partly deprotonate the ammonium groups, leading to (co)polymers with narrow dispersity (≤1.17) for β-benzyl-ʟ-aspartate NCA, whereas with γ-benzyl-ʟglutamate (BLG) NCA, Đ in the range 1.4-1.6 were observed.…”

Amino Acid Block Copolymers with Broad Antimicrobial Activity and Barrier Properties

“…Synthetic cationic polypeptides, especially those containing an abundance of l ‐lysine residues, can display antimicrobial activity and are attractive for their degradability . Recently, this work has been expanded to include soluble statistical copolymers of lysine with various hydrophobic amino acids, graft copolymers on other polymer or particle substrates, and chemically crosslinked hydrogels . These studies point to the potential of using advanced synthetic biopolymers to combine antimicrobial activity with desirable chemical properties, such as degradability.…”