Poly(hydroxy acid) Nanoparticles for the Encapsulation and Controlled Release of Doxorubicin

Khuphe, Mthulisi; Thornton, Paul D.

doi:10.1002/macp.201800352

Cited by 3 publications

(3 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dox loading into polymer nanoparticles was achieved by 'dropping in' a solution of polymer dissolved in DMF to vigorously stirred phosphate buffered saline (PBS) solution that contained Dox. 30 (Table S4). However, in this instance a second peak formed over time that, after 21 days, was representative of particles that possess a hydrodynamic diameter of 31 nm and represented 6.1% of the total sample measured.…”

Section: Resultsmentioning

confidence: 99%

Thermoresponsive polysarcosine-based nanoparticles

Ingram

Rowley

et al. 2019

J. Mater. Chem. B

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Thermoresponsive polysarcosine-based nanoparticles

Ingram

Rowley

et al. 2019

J. Mater. Chem. B

Self Cite

View full text Add to dashboard Cite

show abstract

“…Nanoparticles were produced from the three polymer types by coacervation . DLS analysis revealed increased nanoparticle size with an increased proportion of hydrophobic PBLG within the block co‐polymer (Table ).…”

Section: Methodsmentioning

confidence: 99%

“…Nanoparticles werep roduced from the three polymer types by coacervation. [15] DLS analysisr evealed increased nanoparticle size with an increased proportion of hydrophobic PBLG within the block co-polymer (Table 1). PDI values of PBLG 2 -b-PEG 113 and PBLG 26 -b-PEG 113 were less than, or close to 0.3, indicating the particle stability.P BLG 35 -b-PEG 113 nanoparticles were considered unstableafter 21 days of storagedue to the recorded PDI value (0.437).…”

mentioning

confidence: 96%

Meticulous Doxorubicin Release from pH‐Responsive Nanoparticles Entrapped within an Injectable Thermoresponsive Depot

Ingram

Rowley

et al. 2020

Chemistry A European J

Self Cite

View full text Add to dashboard Cite

The dual stimuli-controlled release of doxorubicin from gel-embedded nanoparticles is reported. Non-cytotoxic polymer nanoparticles are formed from poly(ethylene glycol)-b-poly(benzyl glutamate) that, uniquely,c ontain ac entral ester link. This connection renders the nanoparticles pH-responsive, enabling extensive doxorubicin release in acidic solutions (pH 6.5), but not in solutions of physiological pH (pH 7.4). Doxorubicin-loaded nanoparticles were found to be stable for at least 31 days and lethal against the three breast cancer cell lines tested.F urthermore, doxorubicin-loaded nanoparticles could be incorporated within at hermoresponsive poly(2-hydroxypropyl methacrylate) gel depot, whichf orms immediately upon injection of poly(2-hydroxypropyl methacrylate) in dimethyl sulfoxide solution into aqueous solution. The combination of the poly(2-hydroxypropyl methacrylate) gel and poly(ethyleneg lycol)-b-poly(benzylg lutamate) nanoparticles yields an injectable doxorubicin delivery system that facilities near-complete drug releasew hen maintained at elevated temperatures (37 8C) in acidic solution (pH 6.5). In contrast,n egligible payload release occurs when the material is stored at room temperature in nonacidic solution (pH 7.4). The system has great potential as av ehicle for the prolonged, site-specific release of chemotherapeutics.

show abstract

Long-Lasting In Situ Forming Implant Loaded with Bupivacaine: Investigation on Polymeric and Non-Polymeric Carrier and Solvent Effect

Bazraee

Mobedi

Mashak

et al. 2022

CDD

View full text Add to dashboard Cite

Introduction: Typically, in situ forming implants utilize Poly (lactide-co-glycolide) (PLGA) as a carrier and N-methyl-2-pyrrolidone (NMP) as a solvent. However, it is essential to develop different carriers to release various drugs in a controlled and sustained manner with economic and safety considerations. Objective: The present study aims to evaluate the in-vitro release of Bupivacaine HCl from in situ forming systems as post-operative local anesthesia. Methods: We used Sucrose acetate isobutyrate (SAIB), PLGA 50:50, and a mixture of them as carriers to compare the release behavior. Besides, the effect of PLGA molecular weight (RG 502H, RG 503H, and RG 504H), solvent type, and solvent concentration on the drug release profile was evaluated. The formulations were characterized by investigating their in-vitro drug release, rheological properties, solubility, and DSC, in addition to their morphological properties. Furthermore, the Korsmeyer-Peppas and Weibull models were applied to the experimental data. The results revealed that a mixture of SAIB and PLGA compared to using them solely can extend the Bupivacaine HCl release from 3 days to two weeks. Results: The DSC results demonstrated the compatibility of the mixture by showing a single Tg. The formulation with NMP had a higher burst release and final release in comparison with other solvents by 30% and 96%, respectively. Increasing the solvent concentration from 12% to 32% raised the drug release significantly, which confirmed the larger porosity in the morphology results. From the Korsmeyer-Peppas model, the mechanism of drug release is predicted to be non-Fickian diffusion.

show abstract

Poly(hydroxy acid) Nanoparticles for the Encapsulation and Controlled Release of Doxorubicin

Cited by 3 publications

References 34 publications

Thermoresponsive polysarcosine-based nanoparticles

Thermoresponsive polysarcosine-based nanoparticles

Meticulous Doxorubicin Release from pH‐Responsive Nanoparticles Entrapped within an Injectable Thermoresponsive Depot

Long-Lasting In Situ Forming Implant Loaded with Bupivacaine: Investigation on Polymeric and Non-Polymeric Carrier and Solvent Effect

Contact Info

Product

Resources

About