Thermoresponsive polysarcosine-based nanoparticles

Yu, Huayang; Ingram, Nicola; Rowley, Jason V.; Parkinson, Sam; Green, David C.; Warren, Nicholas J.; Thornton, Paul D.

doi:10.1039/c9tb00588a

Cited by 11 publications

(9 citation statements)

References 29 publications

(30 reference statements)

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“…In a similar work, Thornton et al prepared spherical PSar‐ b ‐PHPMA block copolymer nanoparticles following a similar two‐step approach as O'Reilly. [ 90 ] PSar was synthesized via NCA ROP and a RAFT agent linked by esterification. PSar‐mediated chain extension with HPMA was performed in a 2:10 v/v ethanol/water mixture at 55 °C.…”

Section: Formation Of Pbbns Composed Of Biomolecule–polymer Conjugate...mentioning

confidence: 99%

Polymerization‐Induced Self‐Assembly: An Emerging Tool for Generating Polymer‐Based Biohybrid Nanostructures

Qiu

Han

Xing

et al. 2023

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The combination of biomolecules and synthetic polymers provides an easy access to utilize advantages from both the synthetic world and nature. This is not only important for the development of novel innovative materials, but also promotes the application of biomolecules in various fields including medicine, catalysis, and water treatment, etc. Due to the rapid progress in synthesis strategies for polymer nanomaterials and deepened understanding of biomolecules’ structures and functions, the construction of advanced polymer‐based biohybrid nanostructures (PBBNs) becomes prospective and attainable. Polymerization‐induced self‐assembly (PISA), as an efficient and versatile technique in obtaining polymeric nano‐objects at high concentrations, has demonstrated to be an attractive alternative to existing self‐assembly procedures. Those advantages induce the focus on the fabrication of PBBNs via the PISA technique. In this review, current preparation strategies are illustrated based on the PISA technique for achieving various PBBNs, including grafting‐from and grafting‐through methods, as well as encapsulation of biomolecules during and subsequent to the PISA process. Finally, advantages and drawbacks are discussed in the fabrication of PBBNs via the PISA technique and obstacles are identified that need to be overcome to enable commercial application.

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Section: Formation Of Pbbns Composed Of Biomolecule–polymer Conjugate...mentioning

confidence: 99%

Polymerization‐Induced Self‐Assembly: An Emerging Tool for Generating Polymer‐Based Biohybrid Nanostructures

Qiu

Han

Xing

et al. 2023

Small

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“…In 2019, Yu et al prepared analogous spherical PSar- b -PHPMA block copolymer nanoparticles following a similar two-step approach, involving NCA ROP for the synthesis of a PSar steric stabilizer block and RAFT-mediated dispersion PISA of HPMA in a 2:10 v / v ethanol/water mixture at 55 °C [ 90 ]. In this work, it was crucial that the targeted PHPMA DP was considerably short (≤21 units) in order to minimize the cytotoxicity of the prepared nanoparticles and maintain their size below 200 nm for use as potential drug delivery vehicles.…”

Section: Polypeptide- and Polypeptoid-based Nanostructures Via Pisamentioning

confidence: 99%

“…Th PSar-based vesicles exhibited superior properties, highlighting the great potential of PSa as an alternative hydrophilic block to widely employed PEG-based nanomaterials. In 2019, Yu et al prepared analogous spherical PSar-b-PHPMA block copolymer na noparticles following a similar two-step approach, involving NCA ROP for the synthes of a PSar steric stabilizer block and RAFT-mediated dispersion PISA of HPMA in a 2:1 v/v ethanol/water mixture at 55 °C [90]. In this work, it was crucial that the targete PHPMA DP was considerably short (≤21 units) in order to minimize the cytotoxicity o the prepared nanoparticles and maintain their size below 200 nm for use as potential dru Furthermore, Du and coworkers were the first to develop amphiphilic polypeptidecontaining block copolymer nano-objects by ring-opening polymerization-induced selfassembly (ROPISA) of α-amino acid NCAs in organic media [91].…”

Section: Polypeptide-and Polypeptoid-based Nanostructures Via Pisamentioning

confidence: 99%

Protein-, (Poly)peptide-, and Amino Acid-Based Nanostructures Prepared via Polymerization-Induced Self-Assembly

2021

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Proteins and peptides, built from precisely defined amino acid sequences, are an important class of biomolecules that play a vital role in most biological functions. Preparation of nanostructures through functionalization of natural, hydrophilic proteins/peptides with synthetic polymers or upon self-assembly of all-synthetic amphiphilic copolypept(o)ides and amino acid-containing polymers enables access to novel protein-mimicking biomaterials with superior physicochemical properties and immense biorelevant scope. In recent years, polymerization-induced self-assembly (PISA) has been established as an efficient and versatile alternative method to existing self-assembly procedures for the reproducible development of block copolymer nano-objects in situ at high concentrations and, thus, provides an ideal platform for engineering protein-inspired nanomaterials. In this review article, the different strategies employed for direct construction of protein-, (poly)peptide-, and amino acid-based nanostructures via PISA are described with particular focus on the characteristics of the developed block copolymer assemblies, as well as their utilization in various pharmaceutical and biomedical applications.

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“…[28] PSar, a poly(𝛼-peptoid) derived from N-substituted glycine, imparts high water solubility, low cellular toxicity, and stealth like properties to the material. [29][30][31][32][33] We envisaged that a similar concept could be applied here, i.e., PLys as the cationic gene binding domain and PSar as the hydrophilic domain. However, there are several fundamental challenges associated with this approach.…”

Section: Introductionmentioning

confidence: 99%

Systematic Study of Enzymatic Degradation and Plasmid DNA Complexation of Mucus Penetrating Star‐Shaped Lysine/Sarcosine Polypept(o)ides with Different Block Arrangements

Skoulas

Fattah

Wang

et al. 2022

Macromolecular Bioscience

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Thermoresponsive polysarcosine-based nanoparticles

Abstract: Polysarcosine modified with limited molar amounts of (N-(2-hydroxypropyl)methacrylamide) yields a block copolymer capable of forming thermoresponsive nanoparticles that are suitable for controlled release applications.

Cited by 11 publications

References 29 publications

Polymerization‐Induced Self‐Assembly: An Emerging Tool for Generating Polymer‐Based Biohybrid Nanostructures

Polymerization‐Induced Self‐Assembly: An Emerging Tool for Generating Polymer‐Based Biohybrid Nanostructures

Protein-, (Poly)peptide-, and Amino Acid-Based Nanostructures Prepared via Polymerization-Induced Self-Assembly

Systematic Study of Enzymatic Degradation and Plasmid DNA Complexation of Mucus Penetrating Star‐Shaped Lysine/Sarcosine Polypept(o)ides with Different Block Arrangements

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