The génépi Artemisia species. Ethnopharmacology, cultivation, phytochemistry, and bioactivity

Vouillamoz, José F.; Carlen, Christoph; Taglialatela‐Scafati, Orazio; Pollastro, Federica; Appendino, Giovanni

doi:10.1016/j.fitote.2015.09.007

Cited by 29 publications

(35 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We present the comparison with scientific literature (for the complete data, please see Table S1 ): Achillea millefolium digestive, anti-inflammatory for several problems (stomachache, muscular pain, rash) and disinfectant [ 19 , 23 , 24 , 25 ]; Achillea moschata antioxidant and antibacterial [ 26 ]; Alchemilla vulgaris anti-inflammatory [ 27 , 28 ]; Arnica montana anti-inflammatory for wounds, cutaneous traumas, muscular, and articular pain [ 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ]; Artemisia absinthium digestive [ 31 , 37 , 38 , 39 ] (however, in a review from 2016 the potential antiulcer effect, with the decrease in the production of gastric juice, is reported [ 40 ]); Artemisia genipi digestive and colds [ 39 , 41 ]; Betula pendula diuretic [ 42 ]; Calendula officinalis anti-inflammatory and disinfectant for wounds, rashes, and burns, improves circulation [ 31 , 43 , 44 , 45 , 46 , 47 , 48 ]; Carduus nutans antimicrobial and anti-inflammatory [ 49 ]; Cetraria islandica expectorant [ 50 , 51 , 52 ] and anti-inflammatory [ 51 , 53 ]; Chelidonium majus skin tags and warts [ 54 , 55 ]; Cichorium intybus depurative of the urinary tract […”

Section: Resultsmentioning

confidence: 99%

“…We focused our attention particularly on systematic reviews and meta-analysis, when possible, or on single in vitro, in vivo, and clinical trials studies, applying no time filters. Based on this data, specific and detailed tables were produced ( Table 4 and Supplementary Materials Table S1 [ 2 , 3 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , ...…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Using Medicinal Plants in Valmalenco (Italian Alps): From Tradition to Scientific Approaches

et al. 2020

View full text Add to dashboard Cite

This ethnobotanical survey was carried out in Caspoggio (Valmalenco, SO, Italy) with the purpose of investigating the traditional uses of medicinal plants. Moreover, a bibliographic research meant to validate or refute the uses, focusing on the potentially responsible compounds, was performed. Fifty-nine species, attributable to 30 families (Asteraceae, Pinaceae, Malvaceae, and Lamiaceae the most cited), were mentioned. Arnica montana, anti-inflammatory for traumas and musculoskeletal pains; Pinus mugo, expectorant; Malva sylvestris, anti-inflammatory and soothing; Achillea moschata, digestive. The compounds, responsible for the therapeutic activities, are often polyphenols and terpenoids: helenanin in A. montana, α-pinene, δ-3-carene, and limonene in P. mugo, gossypin and malvin in M. sylvestris, luteolin and apigenin in A. moschata. Scientific evidence for at least one of the traditional activities described was found for 50 species but only in 26 out of 196 works consulted, it is possible to make a comparison between investigated extracts and traditional preparations. This study is thus a stimulus to new phytochemical investigations, mimicking as much as possible the traditional preparations. This work is part of the European Interreg Italy-Switzerland B-ICE project, aimed at creating a management model for the ongoing climate change and searching for new sources of territory valorization as attractions for tourists.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Using Medicinal Plants in Valmalenco (Italian Alps): From Tradition to Scientific Approaches

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Eupatilin (5,7‐dihydroxy‐3′,4′,6‐trimethoxyflavone) is a natural active substance found in génépi group plants. Infusions of génépi group plants has long been used as thermogenic agents to fatigue, indigestion, and airway infections in people . Modern medical research has revealed the pharmacological effects of eupatilin on anti‐inflammatory, anti‐ulcer, anti‐oxidative, and antineoplastic agent .…”

Section: Introductionmentioning

confidence: 99%

Eupatilin regulates proliferation and cell cycle of cervical cancer by regulating hedgehog signalling pathway

Zhao

Zou

Zhang

et al. 2020

Cell Biochemistry & Function

View full text Add to dashboard Cite

Eupatilin (5,7-dihydroxy-3 0 ,4 0 ,6-trimethoxyflavone) is a natural active substance found in génépi group plants, and its pharmacological activities has been proven to be useful in the treatment of various cancers. However, whether eupatilin demonstrates anti-cancer activity in cervical cancer is still under evaluation. To clarify this, cancer cell lines and nude mouse model were used in this study. The results indicated that eupatilin could inhibit the occurrence of cervical cancer both in vivo and in vitro.Cervical cancer cell lines (C4-1, HeLa, Caski, and Siha) and Ect1/E6E7 cells were incubated with eupatilin (40μM) for 48 hours. Compared with the control group, the viability of cervical cancer cells decreased significantly, while the apoptotic cells increased significantly. Cell cycle analysis showed that eupatilin treatment of HeLa and Caski cells reduced the proliferation index. Eupatilin at 40 mg/kg also inhibited tumour growth in tumour-bearing mice. Interestingly, weakened hedgehog signalling was observed in cervical cancer cells and tumours from tumour-bearing mice after eupatilin treatment. Our results reveal the inhibitory effect of eupatilin on cervical cancer and shed new light on the molecular mechanism of its therapeutic effect.

show abstract

“…Alcohol‐based plant infusions are popular in both Europe and Asia. Artemisia species have long been used to flavor alcoholic beverages, giving them a bitter taste and alleged tonic properties (Vouillamoz et al ., ). Artemisia asiatica Nakai is used as an herbal medicine with hepatoprotective, antioxidative, anti‐inflammatory, and antibacterial effects (Je et al ., ).…”

Section: Discussionmentioning

confidence: 97%

Effects of eupatilin on the contractility of corpus cavernosal smooth muscle through nitric oxide‐independent pathways

et al. 2017

View full text Add to dashboard Cite

Eupatilin (5,7-dihydroxy-3,4,6-trimethoxyflavone) is one of the main compounds present in Artemisia species. Eupatilin has both antioxidative and anti-inflammatory properties and a relaxation effect on vascular contraction regardless of endothelial function. We evaluated the relaxant effects of eupatilin on the corpus cavernosum (CC) of rabbits and the underlying mechanisms of its activity in human corpus cavernosum smooth muscle (CCSM) cells. Isolated rabbit CC strips were mounted in an organ bath system. A conventional whole-cell patch clamp technique was used to measure activation of calcium-sensitive K -channel currents in human CCSM cells. The relaxation effect of eupatilin was evaluated by cumulative addition (10 m ~ 3 × 10 m) to CC strips precontracted with 10 m phenylephrine. Western blotting analysis was performed to measure myosin phosphatase targeting subunit 1 (MYPT1) and protein kinase C-potentiated inhibitory protein for heterotrimeric myosin light chain phosphatase of 17-kDa (CPI-17) expression and to evaluate the effect of eupatilin on the RhoA/Rho-kinase pathway. Eupatilin effectively relaxed the phenylephrine-induced tone in the rabbit CC strips in a concentration-dependent manner with an estimated EC value of 1.2 ± 1.6 × 10 m (n = 8, p < 0.05). Iberiotoxin and tetraethylammonium significantly reduced the relaxation effect (n = 8, p < 0.001 and p = 0.003, respectively). Removal of the endothelium or the presence of L-NAME or indomethacin did not affect the relaxation effect of eupatilin. In CCSM cells, the extracellular application of eupatilin 10 m significantly increased the outward currents, and the eupatilin-stimulated currents were significantly attenuated by treatment with 10 m iberiotoxin (n = 13, p < 0.05). Eupatilin reduced the phosphorylation level of MYPT1 at Thr853 of MLCP and CPI-17 at Thr38. Eupatilin-induced relaxation of the CCSM cells via NO-independent pathways. The relaxation effects of eupatilin on CCSM cells were partially due to activation of BK channels and inhibition of RhoA/Rho-kinase.

show abstract

The génépi Artemisia species. Ethnopharmacology, cultivation, phytochemistry, and bioactivity

Cited by 29 publications

References 50 publications

Using Medicinal Plants in Valmalenco (Italian Alps): From Tradition to Scientific Approaches

Using Medicinal Plants in Valmalenco (Italian Alps): From Tradition to Scientific Approaches

Eupatilin regulates proliferation and cell cycle of cervical cancer by regulating hedgehog signalling pathway

Effects of eupatilin on the contractility of corpus cavernosal smooth muscle through nitric oxide‐independent pathways

Contact Info

Product

Resources

About