The gene for the cell adhesion molecule m-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the e-cadherin (uvomorulin) locus in both species

Chromosome 16q24 deletion and decreased E-cadherin expression: Possible association with metastatic potential in prostate cancer

“…E-cadherin belongs to a group of proteins regulating cell adhesions. Among several suggested TSGs localized on chromosome 16q, other cell adhesion regulator genes [10], the M-cadherin gene [23], and the H-cadherin gene [24] are mapped to 16q24. The Ecadherin gene [9], the core binding factor ␤ (CBFB) [25], and the P-cadherin gene [26] are mapped to 16q22.1.…”

cDNA Cloning and Chromosomal Localization of the Human and Mouse Isoforms of Ksp-Cadherin

“…The genes for E-cadherin (CDH1; Berx et al, 1995), Pcadherin (CDH3; Bussemakers et al, 1994), VE-cadherin (CDH5; Suzuki et al, 1991;GDB, July 1997), H-cadherin (CDH13; Lee, 1996), and M-cadherin (CDH15; Kaupmann et al, 1992) have all been mapped to approximately the same region on the long arm of chromosome 16 (16q21-q24). The Ecadherin and P-cadherin genes, in particular, are known to be tandemly arranged within 32 kb of each other (Bussemakers et al, 1994).…”

“…The clustering of human cadherin genes on chromosome 16 has been well preserved in a highly syntenic region of mouse Chromosome 8. The mouse genes for E-cadherin (Cdh1; Eistetter et al, 1988), P-cadherin (Cdh3; Hatta et al, 1991), VE-cadherin (Cdh5; Huber et al, 1996), M-cadherin (Cdh15, Kaupmann et al, 1992), OB-cadherin (Cdh11; Hoffman and Balling, 1995), and now Ksp-cadherin (Cdh16) are all reported to be located within a region spanning 10 -25 cM of Chromosome 8. From an evolutionary standpoint, this clustering of cadherin genes suggests that most members of the cadherin superfamily arose by gene duplication from a single ancestral gene.…”

Identification of Imprinted Loci by Methylation-Sensitive Representational Difference Analysis: Application to Mouse Distal Chromosome 2

“…D83542). M-cadherin maps at the Cdh15 locus on mouse chromosome 8 (Kaupmann et al, 1992), which lies distal to the T26H breakpoint in band A4. Since Chr 8 is the other chromosome involved in the T26H translocation, MatDp.dist2 is accompanied by PatDp.-dist8, indicating that methylation at M-cadherin is lower on the paternal chromosome.…”