The gene family for major urinary proteins: Expression in several secretory tissues of the mouse

Shaw, Phillip; Held, William A.; Hastie, Nicholas D.

doi:10.1016/0092-8674(83)90061-2

Cited by 176 publications

(139 citation statements)

References 28 publications

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“…The hepatocyte-restricted expression of carbamoyl phosphate synthetase I (Cps1) restricts the urea cycle to liver (36,37). Carbonic anhydrase 3 (Car3) and major urinary protein 1 (Mup1) are known for their expression and physiological function in liver (38)(39)(40). The finding that a considerable number of the identified proteins are characteristic markers for the examined tissues gives confidence in the differential protein data.…”

Section: Differential Transcriptome Of Mouse Liver and Kidneymentioning

confidence: 91%

Identification of coexpressed gene clusters in a comparative analysis of transcriptome and proteome in mouse tissues

Mijalski

Harder

Halder

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

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Section: Differential Transcriptome Of Mouse Liver and Kidneymentioning

confidence: 91%

Identification of coexpressed gene clusters in a comparative analysis of transcriptome and proteome in mouse tissues

Mijalski

Harder

Halder

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

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“…Although the liver appears to be the major site of MUP synthesis, recent studies have shown that the MUP gene family is expressed in several secretory tissues of mice (18,34). The tissues expressing MUP mRNA sequences are the liver, the submaxillary gland, the lachrymal gland, and the mammary gland.…”

mentioning

confidence: 99%

“…More recently, hybridization experiments have shown that the MUPs constitute a multigene family of 20 to 30 genes (7,18). Genetic mapping studies with recombinant inbred mice and mouse-hamster hybrid cell lines indicate that the MUP structural genes are clustered on chromosome 4 (5, 7, 20).Although the liver appears to be the major site of MUP synthesis, recent studies have shown that the MUP gene family is expressed in several secretory tissues of mice (18,34). The tissues expressing MUP mRNA sequences are the liver, the submaxillary gland, the lachrymal gland, and the mammary gland.…”

mentioning

confidence: 99%

Differential, multihormonal regulation of the mouse major urinary protein gene family in the liver.

Knopf¹,

Gallagher²,

Held³

1983

Mol. Cell. Biol.

124

131

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The hormonal requirements for the regulation of the major urinary protein (MUP) mRNA levels in mouse liver have been examined. Previous experiments have shown that administration of testosterone to female or castrated male mice increases MUP mRNA levels approximately fivefold to normal male levels. We have found that thyroxine and the peptide hormone, growth hormone, each had a pronounced effect on MUP mRNA levels. MUP mRNA was reduced 150-fold in growth-hormone-deficient mutant mice (little). The administration of growth hormone and thyroxine induced MUP mRNA approximately 150-fold, and when administered together, they induced MUP mRNA approximately 1,000-fold. testosterone administration. When administered separately to these mice, growth hormone and thyroxine induced with MUP mRNA approximately 150-fold, and when administered together, they induced MUP mRNA approximately 1,000-fold. Testicular feminized mice, which lack a functional major testosterone receptor protein, can also be induced to male levels by treatment with both growth hormone and thyroxine. In addition, we present evidence which indicates that growth hormone, thyroxine, and testosterone differentially regulate the levels of distinct MUP mRNA species.The major urinary proteins (MUPs) of mice were originally described as a group of antigenically related low-molecular-weight acidic proteins synthesized in the liver, secreted into the serum, and ultimately excreted in the urine (14-16). A homologous protein, a2.-globulin, has been described in rats (24,31,32). More recently, hybridization experiments have shown that the MUPs constitute a multigene family of 20 to 30 genes (7,18). Genetic mapping studies with recombinant inbred mice and mouse-hamster hybrid cell lines indicate that the MUP structural genes are clustered on chromosome 4 (5, 7, 20).Although the liver appears to be the major site of MUP synthesis, recent studies have shown that the MUP gene family is expressed in several secretory tissues of mice (18,34). The tissues expressing MUP mRNA sequences are the liver, the submaxillary gland, the lachrymal gland, and the mammary gland. These studies also indicated that expression of MUP mRNA in each of the tissues is under different developmental and hormonal controls (34).Early studies on the regulation of the MUPs examined the urinary levels of those proteins whose major site of synthesis appears to be the liver (36; this paper). Parfentjer (28) ed that male mice exhibit high levels of proteinuria and that the onset of this proteinuria correlated with the onset of sexual maturity. The role of the major male sex steroid, testosterone, was further indicated by demonstrating that either females or castrated males treated with testosterone attain normal male levels of proteinuria (38). Biochemical examination of these urinary proteins by Finlayson et al. (16) revealed a group of low-molecular-weight acidic proteins which exhibit both strain-and sex-specific electrophoretically distinguishable phenotypes (14, 37). Interestingly, these studies a...

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“…MUP is the major protein component of mouse urine [55] and is expressed in several different secretory tissues of the mouse [56]. The major site of MUP synthesis is the liver ; the protein is secreted by the liver into serum, where it circulates at relatively low levels before being rapidly filtered by the kidney and excreted.…”

Section: Pheromone Activitymentioning

confidence: 99%

“…In the liver, expression of MUP is stimulated by androgens, principally testosterone, and is modulated by thyroxine and peptide growth hormones : addition of thyroxine or growth factors in the presence of testosterone increases MUP expression 150-fold [57]. However, constitutive expression of MUP has been demonstrated in the salivary and lachrymal glands [56]. The sex-dependent expression of MUP (adult male mice secrete 5-20 times as much MUP as do females) and its ability to bind a number of odorant molecules [57] is consistent with the suggestion that MUP acts as a pheromone transporter [59] ; the protein may be excreted into the urine carrying a bound pheromone which is released as the urine dries and the protein denatures.…”

Section: Pheromone Activitymentioning

confidence: 99%

The lipocalin protein family: structure and function

Flower¹

1996

Biochemical Journal

1,511

1,265

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The lipocalin protein family is a large group of small extracellular proteins. The family demonstrates great diversity at the sequence level ; however, most lipocalins share three characteristic conserved sequence motifs, the kernel lipocalins, while a group of more divergent family members, the outlier lipocalins, share only one. Belying this sequence dissimilarity, lipocalin crystal structures are highly conserved and comprise a single eight-stranded continuously hydrogen-bonded antiparallel β-barrel, which encloses an internal ligand-binding site. Together with two other families of ligand-binding proteins, the fatty-acid-binding proteins (FABPs) and the avidins, the lipocalins form part of an overall structural superfamily : the calycins. Members of the lipocalin family are characterized by several common molecular-

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The gene family for major urinary proteins: Expression in several secretory tissues of the mouse

Cited by 176 publications

References 28 publications

Identification of coexpressed gene clusters in a comparative analysis of transcriptome and proteome in mouse tissues

Identification of coexpressed gene clusters in a comparative analysis of transcriptome and proteome in mouse tissues

Differential, multihormonal regulation of the mouse major urinary protein gene family in the liver.

The lipocalin protein family: structure and function

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