The gender difference of selective serotonin reuptake inhibitor, fluoxetine in adult rats with stress-induced gastric ulcer

Abdel-Sater, Khaled A.; Abdel-Daiem, Wafaa M.; Bakheet, Mohamad Sayyed

doi:10.1016/j.ejphar.2012.04.019

Cited by 13 publications

(7 citation statements)

References 46 publications

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“…Consistently with these results, a 6 month low dose (5 mg/kg/day) treatment with Fluoxetine in rats has been shown to reduce trabecular thickness and increase endocortical bone volume [54]. The dose of Fluoxetine tested by Branco-de-Almeida et al was on the high end of the doses commonly used to suppress serotonin production in rats [55,56], about twice as high as the maximum recommended human dose (MRHD) [54], and was based on a previous work highlighting its anti-inflammatory properties [57]. It is actually possible that this high dose of Fluoxetine may be activating alternative immunomodulatory or antiinflammatory pathways that are responsible for the authors’ observations and that are overcoming the effects on serotonin metabolism.…”

Section: The Wnt Connectionmentioning

confidence: 77%

Serotonin: a novel bone mass controller may have implications for alveolar bone

Galli

Macaluso

Passeri

2013

J Negat Results BioMed

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As recent studies highlight the importance of alternative mechanisms in the control of bone turnover, new therapeutic approaches can be envisaged for bone diseases and periodontitis-induced bone loss. Recently, it has been shown that Fluoxetine and Venlafaxine, serotonin re-uptake inhibitors commonly used as antidepressants, can positively or negatively affect bone loss in rat models of induced periodontitis. Serotonin is a neurotransmitter that can be found within specific nuclei of the central nervous system, but can also be produced in the gut and be sequestered inside platelet granules. Although it is known to be mainly involved in the control of mood, sleep, and intestinal physiology, recent evidence has pointed at far reaching effects on bone metabolism, as a mediator of the effects of Lrp5, a membrane receptor commonly associated with Wnt canonical signaling and osteoblast differentiation. Deletion of Lrp5 in mice lead to increased expression of Tryptophan Hydroxylase 1, the gut isoform of the enzyme required for serotonin synthesis, thus increasing serum levels of serotonin. Serotonin, in turn, could bind to HTR1B receptors on osteoblasts and stop their proliferation by activating PKA and CREB.Although different groups have reported controversial results on the existence of an Lrp5-serotonin axis and the action of serotonin in bone remodeling, there is convincing evidence that serotonin modulators such as SSRIs can affect bone turnover. Consequently, the effects of this drug family on periodontal physiology should be thoroughly explored.

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Section: The Wnt Connectionmentioning

confidence: 77%

Serotonin: a novel bone mass controller may have implications for alveolar bone

Galli

Macaluso

Passeri

2013

J Negat Results BioMed

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“…Fluoxetine is believed to act as a SSRI and frequently used to treat depression [33]. It could increase cortical gamma-aminobutyric acid (GABA) levels in stressed rats [34], and gastroprotective activity of GABA appears to be mediated by increasing the gastric mucosal blood flow that was depended on sensory neuron and NO systems [35]. A more plausible mechanism was presented by Kanof, suggesting that antidepressants could protect gastric mucosa via interactions with H 2 receptors in the brain [36].…”

Section: Discussionmentioning

confidence: 99%

Bidirectional Crosstalk between Stress-Induced Gastric Ulcer and Depression under Chronic Stress

Zhang

Gao

et al. 2012

PLoS ONE

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Stress contributes to a variety of diseases and disorders such as depression and peptic ulcer. The present study aimed to investigate the correlation between stress ulcer and depression in pathogenesis and treatment by using chronic stress depression (CSD), chronic psychological stress ulcer (CPSU) and water immersion restrain stress models in rats. Our data showed that the ulcer index of the animals after CSD exposure was significantly higher than that of controls. Depression-like behaviors were observed in rat after CPSU exposure. Fluoxetine hydrochloride significantly reduced the ulcer index of rats exposed to CPSU stress, while ranitidine inhibited depression-like behavior of the animals in CSD group. The ulcer index of rats administered with mifepristone after CPSU stress was markedly reduced compared to CPSU group, although there was no significant difference in the depression-like behavior between mifepristone-treated CSD group and naive controls. We also found that the rats exposed to CPSU or CSD stress displayed a lower level of corticosterone than naive controls, however, the acute stress (AS) group showed an opposite result. Additionally, in order to study the relevance of H2 receptors and depression, we treated the CSD group with cimetidine and famotidine respectively. The data showed that cimetidine inhibited depression-like behavior in CSD rats, and famotidine had no impact on depression. Overall our data suggested that the hypothalamic-pituitary-adrenal (HPA) axis dysfunction may be the key role in triggering depression and stress ulcer. Acid-suppressing drugs and antidepressants could be used for treatment of depression and stress ulcer respectively. The occurrence of depression might be inhibited by blocking the central H2 receptors.

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“…Approximately 5–10% of people are affected by this disease during their life time [47] . A number of factors have been linked to the genesis of gastric ulcers that include malnutrition, helicobacter pylori infection, use of alcohol, anti-inflammatory drugs, stress, trauma, and burns [1] , [42] , [52] , [56] . Another important factor involved in the formation of gastric ulcers is the disruption of the homeostasis between the defensive (mucin, prostaglandin, bicarbonate, nitric oxide and growth factors) and the offensive factors (increased gastric secretion of pepsin and acid, helicobacter pylori) [56] in the gastric mucosa.…”

Section: Introductionmentioning

confidence: 99%

Vanillin abrogates ethanol induced gastric injury in rats via modulation of gastric secretion, oxidative stress and inflammation

et al. 2016

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Vanillin is commonly used as an additive in food, medicine and cosmetics, but its effect has not yet been studied in gastric injury. Therefore the effect of vanillin was studied in experimental gastric ulcer. Gastric secretion and acidity were studied in pylorus ligated rats. Ulcer index, levels of gastric mucus, malondialdehyde (MDA), myeloperoxidase activity (MPO), expression of nuclear factor kappa B (NF-κB) p65, and histopathological changes were determined in ethanol induced gastric ulcer. Pre treatment with vanillin significantly reduced gastric secretion (P < 0.001) and acidity (P < 0.0001) and gastric ulcer index scores (P < 0.001). and augmented the gastric mucosal defense. Vanillin significantly restored the depleted gastric wall mucus levels (P < 0.0001) induced by ethanol and also significantly attenuated ethanol induced inflammation and oxidative stress by the suppression of gastric MPO activity (P < 0.001), reducing the expression of NF-κB p65 and the increased MDA levels (P < 0.001). Vanillin was also effective in alleviating the damage to the histological architecture and the activation of mast cells induced by ethanol.Together the results of this study highlight the gastroprotective activity of vanillin in gastric ulcers of rats through multiple actions that include inhibition of gastric secretion and acidity, reduction of inflammation and oxidative stress, suppression of expression of NF-κB, and restoration of the histological architecture.

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The gender difference of selective serotonin reuptake inhibitor, fluoxetine in adult rats with stress-induced gastric ulcer

Cited by 13 publications

References 46 publications

Serotonin: a novel bone mass controller may have implications for alveolar bone

Serotonin: a novel bone mass controller may have implications for alveolar bone

Bidirectional Crosstalk between Stress-Induced Gastric Ulcer and Depression under Chronic Stress

Vanillin abrogates ethanol induced gastric injury in rats via modulation of gastric secretion, oxidative stress and inflammation

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