The gastroprotective effect of red propolis extract from Northeastern Brazil and the role of its isolated compounds

Boeing, Thaise; Mejía, Jennyfer Andrea Aldana; Ccana-Ccapatinta, Gari V.; Mariott, Marihá; Silva, Rita de Cássia Melo Vilhena de Andrade Fonseca da; Souza, Priscila de; Mariano, Luísa Nathália Bolda; Oliveira, Graziela Regina; Rocha, Isabelle Moraes da; Costa, Gabriela Altini da; Andrade, Sérgio Faloni de; Silva, Luísa Mota da; Bastos, Jairo Kenupp

doi:10.1016/j.jep.2020.113623

Cited by 17 publications

(41 citation statements)

References 29 publications

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“…With respect to the gastroprotective activity of propolis, different studies show the capacity of this natural product to reduce gastric ulcers [ 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 ]; of these, a lower number of studies have been directed toward the activity of propolis against gastric ulcers induced by NSAIDs. Nevertheless, some authors have studied the activity of some regional propolis on NSAID-induced gastric models.…”

Section: Resultsmentioning

confidence: 99%

“…In general, propolis is known for its antioxidant effects; several studies show the capacity of propolis to decrease oxidative stress in different models inducing gastric ulcers [ 58 , 59 , 60 , 61 , 62 , 63 , 65 , 66 , 182 , 183 ]. The antioxidant effects also are involved in the gastroprotection of propolis in NSAIDs-induced gastric ulcers [ 58 , 59 , 60 ] ( Figure 3 ).…”

Section: Discussionmentioning

confidence: 99%

“…These studies have in common the reduction in lipid peroxidation of propolis in the gastric tissue. This is explained by the increase in the activity of the antioxidant enzymes SOD, CAT, and GPx, which is promoted by the oral treatment with propolis [ 60 , 62 , 63 ]. Antioxidant enzymes are important due to the SOD enzyme catalyzing the dismutation of superoxide radical (O 2 − ) to hydrogen peroxide (H 2 O 2 ); this molecule is captured by the GPx and CAT enzymes and transforms H 2 O 2 into H 2 O and O 2 [ 175 ].…”

Section: Discussionmentioning

confidence: 99%

“…There are many compounds identified in propolis samples that have gastroprotective activity in NSAIDs-induced gastric ulcer models, principally from Brazilian (green and red) propolis, and North Mexican propolis, as shown in Table 2 ; among all these phenolic compounds, some have been reported with gastroprotective effects such as caffeic acid, ferulic acid, cinnamic acid, p -coumaric acid, artepillin C, Kaempferide, 7-O-methylvestitol, aromadendrine-4′-O-methyl ether, formononetin, biochanin A, medicarpine, apigenin, catechin, kaempferol, naringin, and naringenin [ 53 , 54 , 59 , 63 , 68 , 70 , 76 , 88 , 92 , 93 , 94 , 95 , 96 , 98 , 126 , 127 , 128 , 153 , 154 ] or activities related to gastroprotective effects; between them, most classes of phenolic compounds related to the gastroprotective activity of propolis are flavonoids, that include principally five subclasses of this type of compounds (flavonols, isoflavonoids, flavanones, flavones, and a flavanonol) and, phenolic acids, among them compounds derivate of cinnamic acid; and finally, some simple phenols that have been reported with gastroprotective activity as the anethole, catechol and methyl eugenol ( Figure 4 ). Nevertheless, the gastroprotective-related activities of all the phenolic compounds in these propolis samples have not been evaluated.…”

Section: Discussionmentioning

confidence: 99%

“…Flavonoids found in propolis can stimulate and increase mucus and bicarbonate production by means of stimulation of PGE 2 in the gastric epithelial cells and can affect the proton pump activities in gastric parietal cells [ 58 , 59 ]. Formononetin and 7-O-methylvestitol from Brazilian red propolis and aromadendrin-4′-O-methyl-ether and kaempferide from Brazilian green propolis increased the mucin content in damaged gastric tissue [ 59 , 63 , 68 ]. Thus, mucus content contributes to the gastroprotective effect of propolis because the mucus and bicarbonate barrier provides protection to block the diffusion of ROS to the inner part of gastric epithelial cells [ 178 , 184 ] ( Figure 2 ).…”

Section: Discussionmentioning

confidence: 99%

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Propolis and Its Gastroprotective Effects on NSAID-Induced Gastric Ulcer Disease: A Systematic Review

et al. 2021

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Gastric ulcer disease induced by the consumption of NSAIDs is a major public health problem. The therapy used for its treatment causes adverse effects in the patient. Propolis is a natural product that has been used for the treatments of different diseases around the world. Nevertheless, there is little information about the activity of propolis in gastric ulcers caused by treatment with NSAIDs. Therefore, this review evaluates and compares the gastroprotective potential of propolis and its function against NSAID-induced gastric ulcers, for which a systematic search was carried out in the PubMed and ScienceDirect databases. The main criteria were articles that report the gastroprotective activity of propolis against the damage produced by NSAIDs in the gastric mucosa. Gastroprotection was related to the antioxidant, antisecretory, and cytoprotective effects, as well as the phenolic compounds present in the chemical composition of propolis. However, most of the studies used different doses of NSAIDs and propolis and evaluated different parameters. Propolis has proven to be a good alternative for the treatment of gastric ulcer disease. However, future studies should be carried out to identify the compounds responsible for these effects and to determine their potential use in people.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Propolis and Its Gastroprotective Effects on NSAID-Induced Gastric Ulcer Disease: A Systematic Review

et al. 2021

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Brazilian Red Propolis Accelerates Gastric Healing and Reduces Gastric Submucosal Layer Inflammation in Ultrasound‐Monitored Rats

Boeing

Oliveira

Mejía

et al. 2022

Chemistry & Biodiversity

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Propolis has been used for the treatment of gastric disturbances in folk medicine, nevertheless, the gastric healing effects of Brazilian red propolis have not been unveiled. This study aimed to assess the gastric healing effect of the hydroalcoholic extract of red propolis (HERP) in the acetic acid-induced ulcer model. Rats under acetic acid-induced-ulcer were treated with HERP (100 mg/kg, p.o.) twice a day for seven days. Histological changes, oxidative stress, and inflammatory parameters were analyzed in the gastric tissue. Moreover, the gastric wall thickness was measured by ultrasound. The in vitro cytotoxicity of HERP and cellular migration of fibroblasts were evaluated. The treatment with HERP promoted gastric healing, reducing gastric wall thickness, macroscopic lesion area, and histopathological damages compared to the vehicle. Moreover, HERP reduced oxidative stress and inflammation in the gastric tissue but did not change mucin or collagen levels. HERP did not show signs of toxicity either in vivo or in vitro. HERP displayed a healing effect in vivo by reducing oxidative stress and inflammation. These data contribute to validating the popular use of this product in the treatment of gastric disorders and advance scientific knowledge in the search for new drugs for the management of gastric ulcers.

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Comparison of Protective Effect of Aqueous and Ethanolic Extracts of Propolis against Gastric Ulceration in Rats

Şahin

Kaltalıoğlu

Erişgin³

et al. 2023

Chemistry & Biodiversity

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This study focused on the protective effects of different types of propolis extracts on gastric mucosa in indomethacininduced rats. The animals were divided into nine groups: control, negative control (ulcer), positive control (omeprazole), and experimental groups, which were summarized by 200, 400, and 600 mg/kg, bw for aqueous-based and ethanol, respectively. According to the histopathological evaluation, more than others, the doses of 200 and 400 mg/kg of aqueous-based propolis extracts had different degrees of positive effects on the gastric mucosa. Generally, the biochemical analyses of the gastric tissue showed a correlation with microscopic evaluations. According to the phenolic profile analysis, while pinocembrin (684.34 � 1.70 μg/ml) and chrysin (540.54 � 9.06 μg/ml) were the most abundant phenolics in the ethanolic extract, ferulic acid (53.77 � 0.07 μg/ml) and pcoumaric acid (52.61 � 0.42 μg/ml) dominated the aqueousbased extract. Also, the total phenolic content (TPC), total flavonoid content (TFC), and DPPH radical scavenging activity of the ethanolic extract showed almost nine-fold superiority compared to the aqueous-based extracts. Based on data from preclinical data, it was decided that the best doses for the main goal of the study were 200 mg and 400 mg/kg, bw for aqueous-based propolis extract.

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The gastroprotective effect of red propolis extract from Northeastern Brazil and the role of its isolated compounds

Cited by 17 publications

References 29 publications

Propolis and Its Gastroprotective Effects on NSAID-Induced Gastric Ulcer Disease: A Systematic Review

Propolis and Its Gastroprotective Effects on NSAID-Induced Gastric Ulcer Disease: A Systematic Review

Brazilian Red Propolis Accelerates Gastric Healing and Reduces Gastric Submucosal Layer Inflammation in Ultrasound‐Monitored Rats

Comparison of Protective Effect of Aqueous and Ethanolic Extracts of Propolis against Gastric Ulceration in Rats

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