The gastroprotective action of acidic mineral water from the Azhyg-Sug source on the stress-induced injuries to the stomach of white rats

Аракчаа, К. Д.; Салчак, С. М.; Razuvaeva, Ya. G.; Торопова, А. А.; Смирнова, И. Н.; Николаев, С. М.; Merzlikin, A. V.; Пономаренко, Г Н

doi:10.17116/kurort20199602154

Cited by 4 publications

(2 citation statements)

References 2 publications

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“…In addition, these changes promote increased gastric secretion through the production of various substances, reduction of local blood flow, and induction of lipid peroxidation, causing an increase in the generation of reactive oxygen species (Sairam et al, 2002). EIP protects the gastric mucosa from stress-induced injuries at a dose of 500 mg/kg, suggesting that it may prevent the reduction of local blood flow and increase motility, and its effects are related to the reduction of gastric mucosal ischemia and oxidative injuries (Arakchaa et al, 2019;Hersey & Sachs, 1995;Paré & Glavin, 1992).…”

Section: Antiulcerogenic Activitymentioning

confidence: 99%

Chemical, biological, and pharmacological evaluation of the aqueous extract of Ilex paraguariensis, St. Hill. (Aquifoliaceae)

Santos

Schiefer

Surek

et al. 2022

RSD

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This study aimed to quantify the total phenolic and flavonoid contents in the aqueous extract of Ilex paraguariensis (EIP) and investigate its antioxidant, antimicrobial, antiulcerogenic, and antidepressant properties with concomitant verification of its effects on relevant biochemical parameters using in vivo models. EIP has in its composition 236.28 ± 11.83 mg GAE/g of total phenolics and 44.07 ± 5.56 mg QE/g of total flavonoids, corroborating its antioxidant activity. Antimicrobial assays against gram-positive (Staphylococcus aureus and Enterococcus faecalis) and gram-negative bacteria (Escherichia coli e Pseudomonas aeruginosa) showed a promising activity of EIP. The EIP administered at 500 and 1000 mg/kg doses prevented the development of gastric ulcers induced in rats following immobilization at 4 °C, however, in the ethanol-induced ulcers no significant effects were observed up to a dose of 1000 mg/kg. Gastric secretion and total acidity index in pylorus-ligated rats were reduced after treatment with EIP, and the pH did not change significantly compared to the control in the tested model. Administration of EIP to mice (250, 500, and 1000 mg/kg) significantly altered the barbiturate-induced sleep time and results of the tail suspension and forced swim test. Repeated doses of EIP did not significantly alter the evaluated biochemical markers (blood glucose, urea, creatinine, triglycerides, and total cholesterol). The results indicate that EIP may relieve gastrointestinal disorders by reducing acid secretion and decreasing immobility time in mice, suggesting an antidepressant effect. Notably, administration of multiple doses of EIP was considered preliminarily safe.

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Section: Antiulcerogenic Activitymentioning

confidence: 99%

Chemical, biological, and pharmacological evaluation of the aqueous extract of Ilex paraguariensis, St. Hill. (Aquifoliaceae)

Santos

Schiefer

Surek

et al. 2022

RSD

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“…Між тим, є дані про захисну роль глюкокортикоїдів, які підвищуються у кількості у відповідь на гострий стрес [11]. Гастропротекторну дію має сповільнення процесів перекисного окислення ліпідів і посилення активності антиоксидантної системи організму [6,7]. Проведений при водоімерсійному стресі протеомний аналіз клітин показав зміни активності 26 білків; 13 із них були значно активовані, включаючи піруваткіназу і кальретікулін, які тісно пов'язані з енергетичним обміном.…”

Section: рис 1 кількість (а) та площа (б) виразкових уражень шлунку unclassified

Suppression of gastric ulcers formation under immobilization water-immersion stress by preliminary transplantating the multipotent stromal cells

2019

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To investigate the effect of pre-transplantation of multipotent stromal cells (MSCs) of bone marrow on gastric ulcer formation and the state of the immune system in conditions of acute and prolonged stress. Wistar rats reproduced immobilizing water-immersion stress of 2 types: acute and prolonged. Investigated the number and area of stress ulcers, thymus and spleen, as well as hematologic parameters, proliferative and cytotoxic activity of peripheral blood mononuclear cells, splenocytes and cells of lymph nodes, determined the absorption activity of neutrophils. With prolonged stress as a result of MSC transplantation, the number and area of ulcers significantly decreased, indicating the adaptive protective effect of cells. With acute stress, the introduction of MSC had virtually no effect on ulcer formation. With prolonged stress, there was a decrease in thymus, spleen and leukocyte counts in the blood. Under the influence of transplanted MSCs, the number of all mobilized cells was normalized with the exception of lymphocytes. The natural cytotoxicity and proliferative activity of splenocytes, cells of lymph nodes and peripheral blood in acute and prolonged stress as a result of the introduction of MSC did not change significantly. The introduction of bone marrow MSС 24 h before the last reproduction of stress responses in the model of prolonged stress significantly reduced the number and area of ulcers, which generally indicates the anti-ulcer effect of cells, and normalized the stress-induced quantitative cellular changes in the immune system. Transplantation of bone marrow MSCs to rats prior to reproduction of stress enhances the adaptive antistress mechanisms that develop during prolonged stress, leading to suppression of gastric ulcer formation and significantly altering immune system activity. It can be assumed that one of the mechanisms of action on the body of MSCs is to promote the formation of adaptive responses.

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Therapeutic areas of the Republic of Tyva

Sidorina¹,

Dzhabarova²,

Klopotova³

et al. 2022

Vopr. kurortol. fizioter. lech. fiz. kul't.

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The gastroprotective action of acidic mineral water from the Azhyg-Sug source on the stress-induced injuries to the stomach of white rats

Cited by 4 publications

References 2 publications

Chemical, biological, and pharmacological evaluation of the aqueous extract of Ilex paraguariensis, St. Hill. (Aquifoliaceae)

Chemical, biological, and pharmacological evaluation of the aqueous extract of Ilex paraguariensis, St. Hill. (Aquifoliaceae)

Suppression of gastric ulcers formation under immobilization water-immersion stress by preliminary transplantating the multipotent stromal cells

Therapeutic areas of the Republic of Tyva

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