The Gastrointestinal Tract in Hypokinetic Rats

Groza, P; Bordeianu, A; Cananău, S; Ungureanu, Didona; Dragomir, Cristina

doi:10.1016/b978-0-08-023416-8.50029-5

Cited by 2 publications

(1 citation statement)

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“…The effects of hypergravity are being studied mainly at a whole-organism level. As many other stressors, hypergravity influences physiological homoeostasis and affects neuroendocrine (Cananäu et al 1975; Groza et al 1976) and immune (Erofeeva et al 2003; Grigorenko et al 2003) systems, psychophysiological state (Schneider et al 2008), memory performance (Levin et al 2007) and behaviour (Santucci et al 2000). One of the most critical effects of the hypergravity in vertebrates is elevation of arterial pressure that in turn considerably influences other physiological parameters.…”

Section: Introductionmentioning

confidence: 99%

Long-term consequences of a short-term hypergravity load in a snail model

Martynova

Shabelnikov

Bystrova

2014

International Journal of Astrobiology

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Here we focused on the dynamic processes in the snail at different time after short-term hypergravity load (STHL) by monitoring the state of neuroendocrine and immune systems, the nucleic acid synthesis levels in the atrial cells, and the behaviour of the atrial granular cells (GCs). We observed that immediately after centrifugation (14 g for 15 min) in the snail haemolymph concentration of dopamine and noradrenaline (measured by high-performance liquid chromatography) and the number of circulating haemocytes and their proliferative activity (estimated by the direct cell counting and [ 3 H]thymidine incorporation, respectively) increased significantly, whereas the concentration of adrenaline decreased. Twenty-four hours after STHL, the levels of catecholamines and haemocytes returned to their control values. In the atrial epicardial and endothelial cells, a notable drop of transcription activity (evaluated by [ 3 H]uridine autoradiography) from the baseline in the immediate post-STHL period was followed by its gradual increase reaching a maximum at the day 5 and subsequent decrease to control value by the day 10. In endothelial cells, DNA-synthesizing activity (evaluated by [ 3 H]thymidine autoradiography) equal to zero before and just after STHL, increased significantly at the day 5, and decreased by the day 10. The atrial GCs underwent total degranulation. Formed as a result small ungranulated cells exhibited DNA synthesis. Afterwards, most probably, the GCs divided and regranulated. One month after STHL the GC population had been restored. Overall, STHL has triggered an immediate reaction of the neuroendocrine and immune systems and initiated long-lasting processes at a cellular level, which included alterations in activity of nucleic acid syntheses in the epicardial and endothelial cells and remodelling of the GC population in the atrium.

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