The gastric ulcer protective effect of boswellic acids, a leukotriene inhibitor from Boswellia serrata, in rats

Singh, Shashank; Khajuria, Anamika; Taneja, Subhash C.; Khajuria, Rajni; Singh, Jaswant; Johri, R.K.; Qazi, Ghulam N.

doi:10.1016/j.phymed.2008.02.017

Cited by 127 publications

(76 citation statements)

References 16 publications

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“…In fact, the mPGES1 inhibitor MF63 relieved pyresis and inflammatory pain in animal models, without NSAID-like gastric toxicity (Xu et al, 2008). BAs showed gastric ulcer protective effects in different experimental models (Singh et al, 2008), and a 90-day placebo-controlled study supports evidence for the safety of Boswellia serrata extracts in OA patients (Sengupta et al, 2008).…”

Section: Discussionmentioning

confidence: 88%

Inhibition of microsomal prostaglandin E₂ synthase‐1 as a molecular basis for the anti‐inflammatory actions of boswellic acids from frankincense

Siemoneit

Koeberle

Rossi

et al. 2010

British J Pharmacology

109

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BACKGROUND AND PURPOSEFrankincense, the gum resin derived from Boswellia species, showed anti-inflammatory efficacy in animal models and in pilot clinical studies. Boswellic acids (BAs) are assumed to be responsible for these effects but their anti-inflammatory efficacy in vivo and their molecular modes of action are incompletely understood. EXPERIMENTAL APPROACHA protein fishing approach using immobilized BA and surface plasmon resonance (SPR) spectroscopy were used to reveal microsomal prostaglandin E2 synthase-1 (mPGES1) as a BA-interacting protein. Cell-free and cell-based assays were applied to confirm the functional interference of BAs with mPGES1. Carrageenan-induced mouse paw oedema and rat pleurisy models were utilized to demonstrate the efficacy of defined BAs in vivo. KEY RESULTSHuman mPGES1 from A549 cells or in vitro-translated human enzyme selectively bound to BA affinity matrices and SPR spectroscopy confirmed these interactions. BAs reversibly suppressed the transformation of prostaglandin (PG)H2 to PGE2 mediated by mPGES1 (IC50 = 3-10 mM). Also, in intact A549 cells, BAs selectively inhibited PGE2 generation and, in human whole blood, b-BA reduced lipopolysaccharide-induced PGE2 biosynthesis without affecting formation of the COX-derived metabolites 6-keto PGF1a and thromboxane B2. Intraperitoneal or oral administration of b-BA (1 mg·kg -1 ) suppressed rat pleurisy, accompanied by impaired levels of PGE2 and b-BA (1 mg·kg -1 , given i.p.) also reduced mouse paw oedema, both induced by carrageenan. CONCLUSIONS AND IMPLICATIONSSuppression of PGE2 formation by BAs via interference with mPGES1 contribute to the anti-inflammatory effectiveness of BAs and of frankincense, and may constitute a biochemical basis for their anti-inflammatory properties.

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Section: Discussionmentioning

confidence: 88%

Inhibition of microsomal prostaglandin E₂ synthase‐1 as a molecular basis for the anti‐inflammatory actions of boswellic acids from frankincense

Siemoneit

Koeberle

Rossi

et al. 2010

British J Pharmacology

109

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“…Protective measures should focus on gastric muco-sa integrity and affect acid-pepsin secretion, parietal cell activity, mucosal barrier, mucus secretion, blood flow, cell regeneration, and endogenous protective agents especially nitric oxide (Singha et al, 2008). Natural products of plant origin are still a major part of global traditional medicine especially in gastric ulcer.…”

Section: Introductionmentioning

confidence: 99%

Gastroprotective effects of Stachys Lavandulifolia extract on experimental gastric ulcer

Nabavizadeh¹

2011

Afr. J. Pharm. Pharmacol.

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Several studies have used Stachys Lavandulifolia vahl (S. lavandulifolia) as medicinal plant in Iranian folk medicine. The present investigation is designed to elucidate therapeutic and preventive effects of S. lavandulifolia extract on gastric acid and pepsin secretions in experimental gastric ulcer. Thirty two Wistar male rats were used to study therapeutic and preventive effects of S. lavandulifolia extract on alcohol-induced gastric ulcer. Animals were equally (n=8) divided into 4 groups: (I) Control (II) Alcohol (1 ml/200 g/bw) to induce gastric ulcer (III) Alcohol/Lvandu (100 mg/kg bw/daily, S. lavandulifolia extract was given for two weeks post alcohol administration) and (IV) Lvandu/alcohol (S. lavandulifolia extract was given for two weeks before alcohol administration). Ulcer index, gastric acid and pepsin secretions was measured. Ulcer index was significantly decreased in alcohol/Lvandu than Alcohol group. Also gastric acid and pepsin secretions, and gastric tissue's NO metabolites level were significantly lower in alcohol and Lvandu/alcohol groups than control (p<0/05). But changes in gastric acid and pepsin secretions have not been noticeable in alcohol/Lvandu group than control. The results of this study show that S. lavandulifolia extract protected gastric mucosa from alcohol-induced gastric ulcer. This gastroprotection may mediate via gastric mucosal nitric oxide production.

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“…Pyloric ligated models increase in the oxidative and decrease in the antioxidative biomarkers have been reported. [20,21] Hence, as our results indicated maximum in vitro free radical scavenging activity along with ameliorative effect on various ulcerative parameters of Cassia auriculata extract so, this antioxidant potential may be responsible for its anti-ulcerogenic activity. Further studies are needed for their exact mechanism of action on gastric acid secretion and gastric cytoprotection.…”

Section: Resultsmentioning

confidence: 54%

Anti-ulcer activity of cassia auriculata leaf extract

Ahmed

Thayyil

Rasheed

et al. 2010

Pharmacognosy Journal

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A B S t R A c t the present study was carried out to evaluate the anti-ulcer activity of cassia auriculata leaf extract against pylorous ligation induced gastric ulcer. the methanolic leaf extract of cassia auriculata at dose of 300 mg/kg p.o. markedly decrease the incidence of ulcers in pyloric ligatied rats. In pyloric ligated rats, there was an increase in the gastric volume, free and total acidity and ulcerative index as compared to the control group. the methanolic leaf extract of cassia auriculata at dose of, 300 mg/kg showed significant reduction in the above parameters which was comparable to the standard drug famotidine(10 mg/kg). Cassia auriculata extract showed protection index 79.4 %, whereas standard drug famotidine showed protection index 90.7%.

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The gastric ulcer protective effect of boswellic acids, a leukotriene inhibitor from Boswellia serrata, in rats

Cited by 127 publications

References 16 publications

Inhibition of microsomal prostaglandin E₂ synthase‐1 as a molecular basis for the anti‐inflammatory actions of boswellic acids from frankincense

Inhibition of microsomal prostaglandin E₂ synthase‐1 as a molecular basis for the anti‐inflammatory actions of boswellic acids from frankincense

Gastroprotective effects of Stachys Lavandulifolia extract on experimental gastric ulcer

Anti-ulcer activity of cassia auriculata leaf extract

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The gastric ulcer protective effect of boswellic acids, a leukotriene inhibitor from Boswellia serrata, in rats

Cited by 127 publications

References 16 publications

Inhibition of microsomal prostaglandin E2 synthase‐1 as a molecular basis for the anti‐inflammatory actions of boswellic acids from frankincense

Inhibition of microsomal prostaglandin E2 synthase‐1 as a molecular basis for the anti‐inflammatory actions of boswellic acids from frankincense

Gastroprotective effects of Stachys Lavandulifolia extract on experimental gastric ulcer

Anti-ulcer activity of cassia auriculata leaf extract

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Product

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Inhibition of microsomal prostaglandin E₂ synthase‐1 as a molecular basis for the anti‐inflammatory actions of boswellic acids from frankincense

Inhibition of microsomal prostaglandin E₂ synthase‐1 as a molecular basis for the anti‐inflammatory actions of boswellic acids from frankincense