The gastric microbial community,<i>Helicobacter pylori</i>colonization, and disease

Martín, Miriam; Solnick, Jay V.

doi:10.4161/gmic.28573

Cited by 19 publications

(16 citation statements)

References 45 publications

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“…Within this context, we speculate that the effects of H. pylori on asthma or related disease may depend on both the richness and composition of the gut microbiome. Depending on its composition, it might sometimes promote and other times mitigate H. pylori disease . Taken together, these observations from the literature might explain the differences between ethnic groups in the present study.…”

Section: Discussionsupporting

confidence: 66%

Helicobacter pylori in children with asthmatic conditions at school age, and their mothers

Hollander

Voort

Holster

et al. 2016

Aliment Pharmacol Ther

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Background Helicobacter pylori (H. pylori) prevalence in Western countries has been declining simultaneously with increases in childhood asthma and allergic diseases; prior studies have linked these phenomena. Aims We aimed to examine the association between H. pylori colonization in children and risk of asthma and related conditions at school age. We secondly examined additional effects of maternal H. pylori status by pairing with children's status. Methods This study was embedded in a multi-ethnic population-based cohort in Rotterdam, The Netherlands. We measured anti-H. pylori and anti-CagA antibodies in serum of children obtained at age 6 years, and of their mothers obtained during mid-pregnancy. Asthma or related conditions were reported for children at age 6 years. We used multivariate logistic regression analyses among 3,797 subjects. Results In children, the H. pylori positivity rate was 8.7%, and 29.2% of these were CagA-positive. A child's colonization with a CagA-negative-H. pylori strain was associated with an increased risk of asthma (Odds ratio 2.11; 95% CI 1.23-3.60, but this differed for European (3.64; 1.97-6.73) and non-European (0.52; 0.14-1.89) children. When taking into account maternal H. pylori status, only H. pylori positive children with an H. pylori negative mother had increased risk of asthma (2.42; 1.11-5.27), accounting for 3.4% of the asthma risk. Conclusions Colonization of a European child with a CagA-negative-H. pylori strain at age 6 was associated with an increased prevalence of asthma, but there was no association for non-European children. The underlying mechanisms for the observed risk differences require further research.

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Section: Discussionsupporting

confidence: 66%

Helicobacter pylori in children with asthmatic conditions at school age, and their mothers

Hollander

Voort

Holster

et al. 2016

Aliment Pharmacol Ther

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“…A complex disease is rarely caused by a single factor. Previous studies have identified several factors that determine the disease outcome post-H. pylori infection (Martin and Solnick, 2014), whereas most of them have focused on the virulence factors carried by H. pylori, host genetics, and environment. Recently, with a rapid improvement and availability of sequencing-based analysis techniques, the role of host microbiota has attracted the interest of scientists to study disease associated with H. pylori infection (Sheh and Fox, 2013;Yang et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Changes in gastric microbiota induced by Helicobacter pylori infection and preventive effects of Lactobacillus plantarum ZDY 2013 against such infection

Pan

Wan

Xie

et al. 2016

Journal of Dairy Science

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Helicobacter pylori is a gram-negative pathogen linked to gastric ulcers and stomach cancer. Gastric microbiota might play an essential role in the pathogenesis of these stomach diseases. In this study, we investigated the preventive effect of a probiotic candidate Lactobacillus plantarum ZDY 2013 as a protective agent against the gastric mucosal inflammation and alteration of gastric microbiota induced by H. pylori infection in a mouse model. Prior to infection, mice were pretreated with or without 400 µL of L. plantarum ZDY 2013 at a concentration of 10(9) cfu/mL per mouse. At 6 wk postinfection, gastric mucosal immune response and alteration in gastric microbiota mice were examined by quantitative real-time PCR and high-throughput 16S rRNA gene amplicon sequencing, respectively. The results showed that L. plantarum ZDY 2013 pretreatment prevented increase in inflammatory cytokines (e.g., IL-1β and IFN-γ) and inflammatory cell infiltration in gastric lamina propria induced by H. pylori infection. Weighted UniFrac principal coordinate analysis showed that L. plantarum ZDY 2013 pretreatment prevented the alteration in gastric microbiota post-H. pylori infection. Linear discriminant analysis coupled with effect size identified 22 bacterial taxa (e.g., Pasteurellaceae, Erysipelotrichaceae, Halomonadaceae, Helicobacteraceae, and Spirochaetaceae) that overgrew in the gastric microbiota of H. pylori-infected mice, and most of them belonged to the Proteobacteria phylum. Lactobacillus plantarum ZDY 2013 pretreatment prevented this alteration; only 6 taxa (e.g., Lachnospiraceae, Ruminococcaceae, and Clostridiaceae), mainly from the taxa of Firmicutes and Bacteroidetes, were dominant in the gastric microbiota of the L. plantarum ZDY 2013 pretreated mice. Administration of L. plantarum ZDY 2013 for 3 wk led to increase in several bacterial taxa (e.g., Rikenella, Staphylococcus, Bifidobacterium), although a nonsignificant alteration was found in the gastric microbiota. Overall, this study demonstrated that L. plantarum ZDY 2013 pretreatment played an important role in preventing gastric mucosal inflammation and gastric microbiota alteration induced by H. pylori infection, and the selective modulation in gastric microbiota posed by this intervention suggested that targeting gastric microbiota through oral administration of probiotics might be an alternative strategy to prevent H. pylori infection.

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“…Helicobacter pylori (H. pylori) colonizes around 50% of the world population. This bacterium is able to dominate the gastric microbiota and lead to gastric inflammation (gastritis) in infected individuals [1,2]. The conventional treatment for H. pylori infection involves the combination of two antibiotics (amoxicillin/clarithromycin) and a proton pump inhibitor.…”

Section: Introductionmentioning

confidence: 99%

“…It is recognized that the gastric microbial community and the mucosal immune responses determine the outcome of H. pylori infection [12]. Alterations in the microbiota and deregulation of the inflammatory response during H. pylori infection can led to the development of important diseases such as peptic ulcer-, gastric cancer-and mucosa-associated lymphoid tissue (MALT) lymphoma [1,2]. Thus, probiotics have appeared as an alternative to modulate stomach microbiota and/or gastric inflammation and to reduce the severity and complications of H. pylori infection [13,14].…”

Section: Introductionmentioning

confidence: 99%

The Exopolysaccharide of Lactobacillus fermentum UCO-979C Is Partially Involved in Its Immunomodulatory Effect and Its Ability to Improve the Resistance against Helicobacter pylori Infection

et al. 2020

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Lactobacillus fermentum UCO-979C (Lf979C) beneficially modulates the cytokine response of gastric epithelial cells and macrophages after Helicobacter pylori infection in vitro. Nevertheless, no in vivo studies were performed with this strain to confirm its beneficial immunomodulatory effects. This work evaluated whether Lf979C improves protection against H. pylori infection in mice by modulating the innate immune response. In addition, we evaluated whether its exopolysaccharide (EPS) was involved in its beneficial effects. Lf979C significantly reduced TNF-α, IL-8, and MCP-1 and augmented IFN-γ and IL-10 in the gastric mucosa of H. pylori-infected mice. The differential cytokine profile induced by Lf979C in H. pylori-infected mice correlated with an improved reduction in the pathogen gastric colonization and protection against inflammatory damage. The purified EPS of Lf979C reduced IL-8 and enhanced IL-10 levels in the gastric mucosa of infected mice, while no effect was observed for IFN-γ. This work demonstrates for the first time the in vivo ability of Lf979C to increase resistance against H. pylori infection by modulating the gastric innate immune response. In addition, we advanced knowledge of the mechanisms involved in the beneficial effects of Lf979C by demonstrating that its EPS is partially responsible for its immunomodulatory effect.

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The gastric microbial community,Helicobacter pyloricolonization, and disease

Cited by 19 publications

References 45 publications

Helicobacter pylori in children with asthmatic conditions at school age, and their mothers

Helicobacter pylori in children with asthmatic conditions at school age, and their mothers

Changes in gastric microbiota induced by Helicobacter pylori infection and preventive effects of Lactobacillus plantarum ZDY 2013 against such infection

The Exopolysaccharide of Lactobacillus fermentum UCO-979C Is Partially Involved in Its Immunomodulatory Effect and Its Ability to Improve the Resistance against Helicobacter pylori Infection

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