The gastric antisecretory activity of 3-methoxy-5,7,3′4′-tetrahydroxyflavan (ME)—a specific histidine decarboxylase inhibitor in rats

Parmar, N. S.; Hennings, G

doi:10.1007/bf01972340

Cited by 49 publications

(30 citation statements)

References 13 publications

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“…Four hours after ligation, Stomachs were dissected out and contents were collected into tubes. Volume, pH, free acid and total acid content [15] of gastric juice were determined. The stomach was opened along the greater curvature and examined for ulcers.…”

Section: Methodsmentioning

confidence: 99%

Cytoprotective Effect of UlGen, a Polyherbal Formulation against Physical and Chemical Factor Induced Gastric Ulcers in Wister Albino Rats

Muralidhar¹,

Balaji²,

Bandopadhyay³

et al. 2009

American J. of Pharmacology and Toxicology

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Problem statement: UlGen, a Polyherbal formulation, was investigated for its possible Ulcero-protective activity in ulcerogen and Cold-restraint stress induced Wister rats (Rattus rattus). Oral administration of UlGen, at a dose of 800 mg kg −1 significantly protected the onset of coldresistance stress induced ulcerations. Approach: It significantly inhibited gastric ulceration induced by alcohol and aspirin. Control group: Alcohol 80% induced ulcer was 42.00±2.30 and in UlGen treated rats showed 10.00±1.62. Using alcian blue stain to study the mucus secretion by mucosal cells carried out histological examination of gastric glandular mucosa. Results: The volume and acidity of gastric juice in pyloric-ligated rats was reduced in treated rats. Gastric volume (mL 100 g −1 ) in control rats showed 4.12±0.32 and in UlGen treated rats showed 2.50±0.20. Conclusion: UlGen, Cytoprotective effect may be due to the enhancement of defensive mechanism through an improvement of gastric cytoprotection as well as acid inhibition.

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Section: Methodsmentioning

confidence: 99%

Cytoprotective Effect of UlGen, a Polyherbal Formulation against Physical and Chemical Factor Induced Gastric Ulcers in Wister Albino Rats

Muralidhar¹,

Balaji²,

Bandopadhyay³

et al. 2009

American J. of Pharmacology and Toxicology

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“…This effect can be caused by different mechanisms. For example, Parmar and Hennnings (1984) showed that gastric antisecretory activity is as effective at reducing gastric acid secretion as cimetidine (Parmar and Hennings, 1984), and it has been reported that acid output inhibition by greater than 40% is sufficient to prevent the development of esophagitis (Okabe et al, 1995). Furthermore, it has been proposed that gastric acid is essential for esophageal mucosal damage (Bell et al, 1992).…”

Section: Discussionmentioning

confidence: 99%

The Inhibitory Effect of Quercetin-3-O-β-D-Glucuronopyranoside on Gastritis and Reflux Esophagitis in Rats

Min

Lee

Hong

et al. 2009

Korean J Physiol Pharmacol

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It was evaluated the inhibitory action of quercetin-3-O-β-D-glucuronopyranoside (QGC) on reflux esophagitis and gastritis in rats. QGC was isolated from the herba of Rumex Aquaticus. Reflux esophagitis or gastritis was induced surgically or by administering indomethacin, respectively. Oral QGC decreased ulcer index, injury area, gastric volume, and acid output and increased gastric pH as compared with quercetin. Furthermore, QGC significantly decreased gastric lesion sizes induced by exposing the gastric mucosa to indomethacin. Malondialdehyde levels were found to increase significantly after inducing reflux esophagitis, and were reduced by QGC, but not by quercetin or omeprazole. These results show that QGC can inhibit reflux esophagitis and gastritis in rats.

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“…The pH of the gastric juice was measured using a pH meter (Elico, Hyderabad, India). Total acidity were determined by titrating with 0.01 N NaOH using Topfer's reagent and phenolphthalein as indicator (Parmar & Hennings, 1984).…”

Section: Gastric Secretion Studiesmentioning

confidence: 99%

Protective effect of standardized extract ofCleome viscosaagainst experimentally induced gastric lesions in the rat

Gupta

Rao

Sharma

2013

Pharmaceutical Biology

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Context: Cleome viscosa Linn. (Capparidaceae) is used traditionally in the Indian system of medicine as a carminative, anthelmintic, and diuretic, and used for healing wounds, ulcers and diarrhea. Objective: A 70% ethanol (EtOH) extract of the aerial parts of Cleome viscosa extract (CVE) was investigated for gastroprotective activity in different gastric ulcer models in order to validate ethnobotanical claims regarding the plant use in ulcers. Materials and methods: CVE (100, 200 and 400 mg/kg body weight) was administered orally, twice daily for 5 d, for prevention from EtOH, pylorus ligation (PL) and cold restraint stress (CRS)-induced ulcers in rats. Estimation of H þ K þ ATPase activity and gastric wall mucous were performed in EtOH-induced ulcer, antioxidant enzyme activities in supernatant mitochondrial fraction of CRS-induced ulcer, and gastric secretion parameters were estimated in PL-induced ulcer model Results: CVE showed significant (p50.01) dose-dependent inhibition of lesion index in EtOH 15.93-42.30%, PL 26.34-59.28% and CRS 22.58-54.03%, respectively. CVE prevents the oxidative damage of gastric mucosa by blocking lipid peroxidation and by a significant (p50.001) decrease in superoxide dismutase, and an increase in catalase activity. A significant (p50.01) decrease occurred in the level of H þ K þ ATPase, volume of gastric juice and total acidity. Simultaneously, the level of gastric wall mucus and pH were increased significantly (p50.05). High performance thin layer chromatography analysis showed the presence of quercetin and gallic acid (0.3% and 0.25% w/w, respectively) in CVE. Conclusions: Results of our study showed that C. viscosa possesses significant gastroprotective activity, probably due to free radical scavenging activity, and validates the folklore claim.

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The gastric antisecretory activity of 3-methoxy-5,7,3′4′-tetrahydroxyflavan (ME)—a specific histidine decarboxylase inhibitor in rats

Cited by 49 publications

References 13 publications

Cytoprotective Effect of UlGen, a Polyherbal Formulation against Physical and Chemical Factor Induced Gastric Ulcers in Wister Albino Rats

Cytoprotective Effect of UlGen, a Polyherbal Formulation against Physical and Chemical Factor Induced Gastric Ulcers in Wister Albino Rats

The Inhibitory Effect of Quercetin-3-O-β-D-Glucuronopyranoside on Gastritis and Reflux Esophagitis in Rats

Protective effect of standardized extract ofCleome viscosaagainst experimentally induced gastric lesions in the rat

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