The gas5 gene is disrupted by a frameshift mutation within its longest open reading frame in several inbred mouse strains and maps to murine Chromosome 1

Muller, Alexander J.; Chatterjee, Seema; Teresky, Angelika K.; Levine, Arnold J.

doi:10.1007/s003359900862

Cited by 34 publications

(23 citation statements)

References 10 publications

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“…GAS5 transcripts display many different patterns of alternate splicing but its putative open reading frame is small and poorly conserved during even relatively short periods of evolution (Muller et al, 1998;Raho et al, 2000). It has therefore been deduced that any important biological activity of GAS5 must be mediated through the introns, which encode multiple small nucleolar RNAs (snoRNAs) (Smith and Steitz, 1998).…”

Section: Long Non-coding Rna Gas5 Functions As a Tumor Suppressor In mentioning

confidence: 99%

Long Non-coding RNA GAS5 Functions as a Tumor Suppressor in Renal Cell Carcinoma

Qiao¹,

Gao²,

Huo³

et al. 2013

Asian Pacific Journal of Cancer Prevention

210

152

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Background: Renal cell carcinoma (RCC) is a malignancy with a poor prognosis. We aimed to explore whether the expression of Long Non-Coding RNA (LncRNA) growth arrest-specific transcript 5 (GAS5) is associated with RCC genesis. Methods: We selected twelve clinical samples diagnosed for renal clear cell carcinoma and found that the LncRNA GAS5 transcript levels were significantly reduced relative to those in adjacent unaffected normal renal tissues. Results: In addition, expression of GAS5 was lower in the RCC cell line A498 than that in normal renal cell line HK-2. Furthermore, using functional expression cloning, we found that overexpression of GAS5 in A498 cells inhibited cell proliferation, induced cell apoptosis and arrested cell cycling. At the same time, the migration and invasion potential of A498 cells were inhibited compared to control groups. Conclusion: Our study provided the first evidence that a decrease in GAS5 expression is associated with RCC genesis and progression and overexpression of GAS5 can act as a tumor suppressor for RCC, providing a potential attractive therapeutic approach for this malignancy.

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Section: Long Non-coding Rna Gas5 Functions As a Tumor Suppressor In mentioning

confidence: 99%

Long Non-coding RNA GAS5 Functions as a Tumor Suppressor in Renal Cell Carcinoma

Qiao¹,

Gao²,

Huo³

et al. 2013

Asian Pacific Journal of Cancer Prevention

210

152

View full text Add to dashboard Cite

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“…GAS5a is the main isoform at 77 nt in length whereas GAS5b has only 45 nt, missing 32 nt. However, the putative open reading frame is small and poorly conserved (13,21). GAS5 is non-protein coding but its RNA is spliced, polyadenylated, and associated with ribosomes (22).…”

Section: Structural Characterization and Biological Functions Of Gas5mentioning

confidence: 99%

“…LncRNA growth arrest-specific transcript 5 (GAS5) was originally identified in 1988 (12)(13)(14). GAS5 was named due to its increased expression upon cell growth arrest (12).…”

Section: Introductionmentioning

confidence: 99%

Long non-coding RNA growth arrest-specific transcript 5 in tumor biology

2015

Oncology Letters

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Abstract. The recognition of the biological relevance of long non-coding RNA (lncRNA) molecules has only recently been recognized as one of the most significant advances in contemporary molecular biology. A growing body of evidence indicates that lncRNAs act not only as the intermediary between DNA and protein but also as significant protagonists of cellular functions. The dysregulation of lncRNAs has increasingly been linked to numerous human diseases, particularly cancers. Recent studies have demonstrated that the lncRNA growth arrest-specific transcript 5 (GAS5) was pervasively downexpressed in most human cancers compared with non-cancerous adjacent tissues including gastric, breast, lung and prostate cancer. In addition, patients with decreased GAS5 expression have a significantly poorer prognosis than those with higher expression. Furthermore, GAS5 is involved in the control of cell apoptosis, proliferation, metastasis, angiogenesis, DNA repair and tumor cell metabolism. This review provides an overview of the current knowledge concerning the role of GAS5 in tumor expression and biology function.

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“…Subsequent studies showed that GAS5 transcripts displayed many different patterns of alternate splicing but that the putative open reading frame (ORF) was small and poorly conserved during even relatively short periods of evolution (Muller et al, 1998;Raho et al, 2000). It has therefore been deduced that any important biological activity of GAS5 must be mediated through the introns, which encode multiple small nucleolar RNAs (snoRNAs; Smith and Steitz, 1998).…”

Section: Introductionmentioning

confidence: 99%

GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer

et al. 2008

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Effective control of both cell survival and cell proliferation is critical to the prevention of oncogenesis and to successful cancer therapy. Using functional expression cloning, we have identified GAS5 (growth arrest-specific transcript 5) as critical to the control of mammalian apoptosis and cell population growth. GAS5 transcripts are subject to complex post-transcriptional processing and some, but not all, GAS5 transcripts sensitize mammalian cells to apoptosis inducers. We have found that, in some cell lines, GAS5 expression induces growth arrest and apoptosis independently of other stimuli. GAS5 transcript levels were significantly reduced in breast cancer samples relative to adjacent unaffected normal breast epithelial tissues. The GAS5 gene has no significant protein-coding potential but expression encodes small nucleolar RNAs (snoRNAs) in its introns. Taken together with the recent demonstration of tumor suppressor characteristics in the related snoRNA U50, our observations suggest that such snoRNAs form a novel family of genes controlling oncogenesis and sensitivity to therapy in cancer.

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The gas5 gene is disrupted by a frameshift mutation within its longest open reading frame in several inbred mouse strains and maps to murine Chromosome 1

Cited by 34 publications

References 10 publications

Long Non-coding RNA GAS5 Functions as a Tumor Suppressor in Renal Cell Carcinoma

Long Non-coding RNA GAS5 Functions as a Tumor Suppressor in Renal Cell Carcinoma

Long non-coding RNA growth arrest-specific transcript 5 in tumor biology

GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer

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