The G to A polymorphism at -597 of the interleukin-6 gene is extremely rare in southern Han Chinese

Gao, Shu-Ping; Pan, Min; Chen, Chu; Ge, Lijia; Jiang, Min-Hui; Luan, Hong; Zheng, Jie; Deng, Xintao; Zhu, Jianhua

doi:10.1016/j.cyto.2011.03.006

Cited by 6 publications

(11 citation statements)

References 36 publications

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“…However plasma IL-6 levels are very low in healthy individuals they increased rapidly in infection, trauma or stress conditions (Jenny et al 2002). Plasma IL-6 levels show great differences even among healthy individuals, related to both genetic and environmental factors (Gao et al 2011;Jenny et al 2002). These differences may be explained by IL-6 gene variations (Sesso et al 2006;Gao et al 2011;Fishman et al 1998).…”

Section: Introductionmentioning

confidence: 99%

“…It is one of the most important acute-phase response mediators and regulates CRP production in hepatocytes (Gao et al 2011;Ridker et al 2000;Jenny et al 2002;Berg et al 2009;Baumann and Gauldie 1994). It has been found that both IL-6 and CRP are associated with HT and coronary heart disease in the manner of endothelial dysfunction and impaired fibrinolysis (Humphries et al 2001;Boos and Lip 2006).…”

Section: Introductionmentioning

confidence: 99%

“…Plasma IL-6 levels show great differences even among healthy individuals, related to both genetic and environmental factors (Gao et al 2011;Jenny et al 2002). These differences may be explained by IL-6 gene variations (Sesso et al 2006;Gao et al 2011;Fishman et al 1998). The IL-6 gene is located at p21 of chromosome 7, contains a 1.3 kb coding sequence with five exons and encodes a 23.7 kd protein.…”

Section: Introductionmentioning

confidence: 99%

“…Inflammation is an independent risk factor that may act on initiation and development of HT disease (Li et al 2005;Bautista et al 2005;Sesso et al 2006). Recent studies show increased baseline plasma inflammatory marker levels such as IL-6 and C-reactive protein (CRP) in HT and CVD (Wang et al 2011;Sesso et al 2006;Humphries et al 2001;Gao et al 2011;Bermudez et al 2002;Ridker et al 2000).…”

Section: Introductionmentioning

confidence: 99%

“…Interleukin-6 is a cytokine that plays an essential role in cellular and humoral immune response and is related to inflammation, host defense, and tissue injury (Gao et al 2011;Ridker et al2000). It is one of the most important acute-phase response mediators and regulates CRP production in hepatocytes (Gao et al 2011;Ridker et al 2000;Jenny et al 2002;Berg et al 2009;Baumann and Gauldie 1994).…”

Section: Introductionmentioning

confidence: 99%

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Investigation of relationship between IL-6 gene variants and hypertension in Turkish population

et al. 2014

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Investigation of relationship between IL-6 gene variants and hypertension in Turkish population

et al. 2014

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Association of IL-6 polymorphisms with gastric cancer risk: Evidences from a meta-analysis

Wang

Liu

et al. 2012

Cytokine

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Interleukin-6 Promoter Polymorphisms and Susceptibility to Atrial Fibrillation in Elderly Han Chinese Patients with Essential Hypertension

Song²,

Jiang³

et al. 2012

Journal of Interferon & Cytokine Research

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There is an accumulating body of evidence indicating a strong association between inflammation and the pathogenesis of atrial fibrillation (AF). Interleukin-6 (IL-6) is a pleiotropic cytokine, functions as a mediator of inflammatory response, and has both proinflammatory and anti-inflammatory properties. The aim of the present study was to investigate the association of the -634C/G polymorphism of the IL-6 gene with AF in elderly Han Chinese patients with essential hypertension (EH). A total of 169 elderly patients with EH were eligible for this study. Patients with AF (n=75) were allocated to the AF group, and 94 subjects without AF to the control group. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to assess the genotype frequencies. The distribution of the IL-6 -634C/G genotypes (CC, CG, and GG) was 67.02%, 30.85%, and 2.13% in the controls, and 50.67%, 40.00%, and 9.33% in AF subjects, respectively (P=0.0312). The frequency of the G allele in the AF group was significantly higher than that in the control group (29.33% vs. 17.55%, P=0.0103). Compared with the CC and CG genotypes, the GG homozygote had a 4.7353-fold increased risk of AF [95% confidence interval (CI)=0.9537-23.5116, P=0.0382]. These findings suggest that the IL-6 -634C/G polymorphism is associated with AF, and the G allele has increased risk of AF in elderly Han Chinese patients with EH.

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The G to A polymorphism at -597 of the interleukin-6 gene is extremely rare in southern Han Chinese

Cited by 6 publications

References 36 publications

Investigation of relationship between IL-6 gene variants and hypertension in Turkish population

Investigation of relationship between IL-6 gene variants and hypertension in Turkish population

Association of IL-6 polymorphisms with gastric cancer risk: Evidences from a meta-analysis

Interleukin-6 Promoter Polymorphisms and Susceptibility to Atrial Fibrillation in Elderly Han Chinese Patients with Essential Hypertension

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