Investigation of relationship between IL-6 gene variants and hypertension in Turkish population

Karaman, Esin; Kucuk, Meral Urhan; Bayramoglu, Aysegul; Gocmen, Semire Uzun; Ercan, Süleyman; Güler, Halil İbrahim; Kucukkaya, Yunus; Erden, Sema

doi:10.1007/s10616-014-9732-1

Cited by 7 publications

(7 citation statements)

References 38 publications

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“…We failed to detect any significant differences among ethnicities. Intuitively, our results were inconsistent with the previous meta-analysis by Niu et al 22 because our meta-analysis was superior due to the following reasons: first, we included more recently published studies, 11 , 16 , 74 , 75 which were not available at the time of the previous meta-analysis. Second, the −174 G>C polymorphism was rare in eastern Asian populations 94 and had a relatively high allele frequency in Caucasians (40%).…”

Section: Discussioncontrasting

confidence: 91%

“…Further exploration of the heterogeneity was conducted by Galbraith plots in 4 genetic models. We finally found that the studies by Karaman et al 74 and Jeng et al 76 were located outside of the 2 lines in the plots (Figure 5 ). After the studies by Jeng et al and Karaman et al were omitted from the corresponding models, all I 2 values decreased to less than 50% in all of the genetic models, and the pooled ORs and 95% CIs were not materially altered (data not shown).…”

Section: Resultsmentioning

confidence: 70%

“…In the end, Galbraith plots were drawn to detect the outliners leading to heterogeneity. All I 2 values immediately decreased to below 50% and the P values of the Q-test were greater than 0.1 after excluding the Jeng et al 76 or Karaman et al 74 study. Moreover, the 95% CIs still contained 1 in 4 genetic models after removing these studies, proving that our results were robust.…”

Section: Discussionmentioning

confidence: 84%

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Association Between Interleukin-6 -572 C>G and -174 G>C Polymorphisms and Hypertension

Sun

Wang

et al. 2016

Medicine

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Section: Discussioncontrasting

confidence: 91%

Section: Resultsmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 84%

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Association Between Interleukin-6 -572 C>G and -174 G>C Polymorphisms and Hypertension

Sun

Wang

et al. 2016

Medicine

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“…The cytokine Interleukin-6 (IL-6) is a fundamental mediator of the acute-phase response to endothelial injury and regulates the production of C Reactive Protein (CRP) in hepatocytes [ 23 ]; therefore, both IL-6 and CRP genetic variants have been evaluated in relation to hypertension [ 2 , 20 ]. In the paper from Karaman et al [ 24 ], IL-6 rs1800795 and rs1800796 SNPs (MAF = 14.12% and 31.39%, respectively, 1000 Genomes) were genotyped in a Turkish sample of 108 controls and 111 hypertension patients. Both SNPs genotypes were not significantly related to hypertension or to IL-6 and CRP plasma levels.…”

Section: Resultsmentioning

confidence: 99%

Advances in the Genetics of Hypertension: The Effect of Rare Variants

Russo

Gaetano

Cugliari

et al. 2018

IJMS

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Worldwide, hypertension still represents a serious health burden with nine million people dying as a consequence of hypertension-related complications. Essential hypertension is a complex trait supported by multifactorial genetic inheritance together with environmental factors. The heritability of blood pressure (BP) is estimated to be 30–50%. A great effort was made to find genetic variants affecting BP levels through Genome-Wide Association Studies (GWAS). This approach relies on the “common disease–common variant” hypothesis and led to the identification of multiple genetic variants which explain, in aggregate, only 2–3% of the genetic variance of hypertension. Part of the missing genetic information could be caused by variants too rare to be detected by GWAS. The use of exome chips and Next-Generation Sequencing facilitated the discovery of causative variants. Here, we report the advances in the detection of novel rare variants, genes, and/or pathways through the most promising approaches, and the recent statistical tests that have emerged to handle rare variants. We also discuss the need to further support rare novel variants with replication studies within larger consortia and with deeper functional studies to better understand how new genes might improve patient care and the stratification of the response to antihypertensive treatments.

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“…This healthy problem is a highly complex genetic and multi-factorial disease that affected by genetic influences and environmental factors. Karaman et al reported that SNPs in candidate genes are susceptible to these multifactorial diseases [3]. Many reports with Asians showed us that a positive association detected between the 572 G / C polymorphism with CAD risk [27,28,33], while no such association in studies with Caucasian populations [21,23,24,25].…”

Section: Discussionmentioning

confidence: 99%

INVESTIGATION OF RELATIONSHIP BETWEEN rs1800796 VARIANTS OF INTERLEUKINE-6 GENE AND CORONARY ARTERY DISEASE

Güler¹

2019

ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY –C Life Sciences and Biotechnology

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The most important characteristic of coronary artery disease, which is one of the most prevalent and most important healthy problem today, is that it can lead to life-threatening myocardial infarction in advanced stages. It is more important to take protective preventions by knowing the risk factors that cause the disease rather than the treatment of this disease. This study included determining the frequency of interleukin-6 (IL-6) gene 572 G / C polymorphism in individuals with coronary artery disease (CAD) and determining the role of that polymorphism in the development of CAD. In the current study, DNAs were isolated from the blood of a total of 185 individuals (103 coronary patients and 82 controls) by the salt method. Genotypes of IL-6 572 G / C polymorphism were detected by using molecular techniques (PCR, RFLP and electrophoresis) from these isolated DNAs. The results obtained were evaluated statistically. According to these results, the frequencies of 572 G / C genotype were 83% for GC, 17% for GC, 0% for CC in control subjects for CAD; whereas in patients, GG 72%, GC 28% and CC 0% were detected in the patients. No statistically considerable difference was determined between control and patient groups in terms of frequency of 572 G / C alleles and the GG genotype was significantly higher in the patient group. Based on the results of the currently study, we can say that there is no correlation between coronary artery disease and IL-6 572 G / C polymorphism frequency.

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Investigation of relationship between IL-6 gene variants and hypertension in Turkish population

Cited by 7 publications

References 38 publications

Association Between Interleukin-6 -572 C>G and -174 G>C Polymorphisms and Hypertension

Association Between Interleukin-6 -572 C>G and -174 G>C Polymorphisms and Hypertension

Advances in the Genetics of Hypertension: The Effect of Rare Variants

INVESTIGATION OF RELATIONSHIP BETWEEN rs1800796 VARIANTS OF INTERLEUKINE-6 GENE AND CORONARY ARTERY DISEASE

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